Myeloperoxidase as a Potential Biomarker of Acute-Myocardial-Infarction-Induced Depression and Suppression of the Innate Immune System
While myeloperoxidase (MPO) serves as an indicator of both neutrophil and innate-immune-system function, the potential suppression of the innate immune system in patients with acute myocardial infarction (AMI)-induced depression might be evidenced by a decrease in MPO serum levels. The aim of this p...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/11/11/2083 |
| _version_ | 1797469379555753984 |
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| author | Andreas Baranyi Dietmar Enko Andreas Meinitzer Dirk Von Lewinski Hans-Bernd Rothenhäusler Leonhard Harpf Heimo Traninger Barbara Obermayer-Pietsch Birgit M. Harb Melanie Schweinzer Moritz Platzer Sieglinde Zelzer |
| author_facet | Andreas Baranyi Dietmar Enko Andreas Meinitzer Dirk Von Lewinski Hans-Bernd Rothenhäusler Leonhard Harpf Heimo Traninger Barbara Obermayer-Pietsch Birgit M. Harb Melanie Schweinzer Moritz Platzer Sieglinde Zelzer |
| author_sort | Andreas Baranyi |
| collection | DOAJ |
| description | While myeloperoxidase (MPO) serves as an indicator of both neutrophil and innate-immune-system function, the potential suppression of the innate immune system in patients with acute myocardial infarction (AMI)-induced depression might be evidenced by a decrease in MPO serum levels. The aim of this prospective study was to (1) determine whether serum concentrations of MPO vary immediately and 6 months after AMI and (2) to investigate whether MPO concentrations at the time of the AMI are significant predictors of AMI-induced depression and the depression-associated suppression of the innate immune system. A total of 109 AMI patients were assessed with the Hamilton Depression Scale (HAMD-17) immediately after admission to the hospital and 6 months later. The MPO status was assessed with serum samples, which were also collected immediately and 6 months after AMI. The depressive patients showed significantly lower MPO blood levels immediately and 6 months after the AMI compared to the patients without depression (ANCOVA: MPO (depression) F = 4.764, df = 1, <i>p</i> = 0.031). The baseline MPO was observed as a significant predictor (<i>p</i> = 0.027) of AMI-induced depression 6 months after AMI. MPO is a potential biomarker for AMI-induced depression, indicating a depression-associated suppression of the innate immune system. |
| first_indexed | 2024-03-09T19:19:34Z |
| format | Article |
| id | doaj.art-f3edfeea2fef4ff68d2a1308ee9e6932 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-09T19:19:34Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-f3edfeea2fef4ff68d2a1308ee9e69322023-11-24T03:28:56ZengMDPI AGAntioxidants2076-39212022-10-011111208310.3390/antiox11112083Myeloperoxidase as a Potential Biomarker of Acute-Myocardial-Infarction-Induced Depression and Suppression of the Innate Immune SystemAndreas Baranyi0Dietmar Enko1Andreas Meinitzer2Dirk Von Lewinski3Hans-Bernd Rothenhäusler4Leonhard Harpf5Heimo Traninger6Barbara Obermayer-Pietsch7Birgit M. Harb8Melanie Schweinzer9Moritz Platzer10Sieglinde Zelzer11Division of Psychiatry and Psychotherapeutic Medicine, Medical University of Graz, 8036 Graz, AustriaClinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, 8036 Graz, AustriaClinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, 8036 Graz, AustriaDivision of Cardiology, Department of Internal Medicine, Medical University of Graz, 8036 Graz, AustriaDivision of Psychiatry and Psychotherapeutic Medicine, Medical University of Graz, 8036 Graz, AustriaPRO-DOC Cardiac Rehabilitation, 8020 Graz, AustriaPRO-REHA Cardiac Rehabilitation, 8020 Graz, AustriaEndocrinology Lab Platform, Division of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, 8036 Graz, AustriaSKA-RZ St. Radegund für Herz-Kreislauferkrankungen, 8061 St. Radegund bei Graz, AustriaDivision of Psychiatry and Psychotherapeutic Medicine, Medical University of Graz, 8036 Graz, AustriaKlinikum Favoriten, 1100 Vienna, AustriaClinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, 8036 Graz, AustriaWhile myeloperoxidase (MPO) serves as an indicator of both neutrophil and innate-immune-system function, the potential suppression of the innate immune system in patients with acute myocardial infarction (AMI)-induced depression might be evidenced by a decrease in MPO serum levels. The aim of this prospective study was to (1) determine whether serum concentrations of MPO vary immediately and 6 months after AMI and (2) to investigate whether MPO concentrations at the time of the AMI are significant predictors of AMI-induced depression and the depression-associated suppression of the innate immune system. A total of 109 AMI patients were assessed with the Hamilton Depression Scale (HAMD-17) immediately after admission to the hospital and 6 months later. The MPO status was assessed with serum samples, which were also collected immediately and 6 months after AMI. The depressive patients showed significantly lower MPO blood levels immediately and 6 months after the AMI compared to the patients without depression (ANCOVA: MPO (depression) F = 4.764, df = 1, <i>p</i> = 0.031). The baseline MPO was observed as a significant predictor (<i>p</i> = 0.027) of AMI-induced depression 6 months after AMI. MPO is a potential biomarker for AMI-induced depression, indicating a depression-associated suppression of the innate immune system.https://www.mdpi.com/2076-3921/11/11/2083myeloperoxidasedepressioninnate immune systemacute myocardial infarction |
| spellingShingle | Andreas Baranyi Dietmar Enko Andreas Meinitzer Dirk Von Lewinski Hans-Bernd Rothenhäusler Leonhard Harpf Heimo Traninger Barbara Obermayer-Pietsch Birgit M. Harb Melanie Schweinzer Moritz Platzer Sieglinde Zelzer Myeloperoxidase as a Potential Biomarker of Acute-Myocardial-Infarction-Induced Depression and Suppression of the Innate Immune System Antioxidants myeloperoxidase depression innate immune system acute myocardial infarction |
| title | Myeloperoxidase as a Potential Biomarker of Acute-Myocardial-Infarction-Induced Depression and Suppression of the Innate Immune System |
| title_full | Myeloperoxidase as a Potential Biomarker of Acute-Myocardial-Infarction-Induced Depression and Suppression of the Innate Immune System |
| title_fullStr | Myeloperoxidase as a Potential Biomarker of Acute-Myocardial-Infarction-Induced Depression and Suppression of the Innate Immune System |
| title_full_unstemmed | Myeloperoxidase as a Potential Biomarker of Acute-Myocardial-Infarction-Induced Depression and Suppression of the Innate Immune System |
| title_short | Myeloperoxidase as a Potential Biomarker of Acute-Myocardial-Infarction-Induced Depression and Suppression of the Innate Immune System |
| title_sort | myeloperoxidase as a potential biomarker of acute myocardial infarction induced depression and suppression of the innate immune system |
| topic | myeloperoxidase depression innate immune system acute myocardial infarction |
| url | https://www.mdpi.com/2076-3921/11/11/2083 |
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