Defective GABAergic neurotransmission in the nucleus tractus solitarius in Mecp2-null mice, a model of Rett syndrome

Defective GABAergic neurotransmission in the nucleus tractus solitarius in Mecp2-null mice, a model of Rett syndrome

Rett syndrome (RTT) is a devastating neurodevelopmental disorder caused by loss-of-function mutations in the X-linked methyl-CpG binding protein 2 (Mecp2) gene. GABAergic dysfunction has been implicated contributing to the respiratory dysfunction, one major clinical feature of RTT. The nucleus tract...

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Bibliographic Details
Main Authors: Chao-Yin Chen, Jacopo Di Lucente, Yen-Chu Lin, Cheng-Chang Lien, Michael A. Rogawski, Izumi Maezawa, Lee-Way Jin
Format: Article
Language:English
Published: Elsevier 2018-01-01
Series:Neurobiology of Disease
Subjects:
NTS
GABA
Rett syndrome
Extrasynaptic receptors
Patch clamp
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996117302164

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