Daucosterol derived from Cordyceps (a Traditional Chinese Medicine) as a possible lead compound for allergic transfusion reactions
Allergic transfusion reaction is an anomaly that develops within several hours of transfusion which is usually treated by antihistamine. In the present study, we are looking into daucosterol, an extract of Traditional Chinese Medicine (TCM) Cordyceps, as a potential inhibitor of histidine decarboxyl...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Bangladesh Pharmacological Society
2015-01-01
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| Series: | Bangladesh Journal of Pharmacology |
| Subjects: | |
| Online Access: | https://www.banglajol.info/index.php/BJP/article/view/20498 |
| _version_ | 1818499501945520128 |
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| author | Jian Yang Ji-Xia Li Zhe Song Xi-Yan Xia |
| author_facet | Jian Yang Ji-Xia Li Zhe Song Xi-Yan Xia |
| author_sort | Jian Yang |
| collection | DOAJ |
| description | Allergic transfusion reaction is an anomaly that develops within several hours of transfusion which is usually treated by antihistamine. In the present study, we are looking into daucosterol, an extract of Traditional Chinese Medicine (TCM) Cordyceps, as a potential inhibitor of histidine decarboxylase. The approach of molecular docking and Molecular Dynamics Simulation (MDS) on a traditional anti-inflammatory Chinese medicine gave an atomic insight of the inhibition. The daucosterol was binding with a ?G of -3.17 Kcal/mol, to inhibit histamine synthesis by binding to histidine decarboxylase, possibly via the flexible catalytic loop. Such inhibitors that were designed to block the flexibility of the catalytic loop are potential candidates for further drug development program. |
| first_indexed | 2024-12-10T20:30:25Z |
| format | Article |
| id | doaj.art-f3ef031272fc435ca0f1715af5af719c |
| institution | Directory Open Access Journal |
| issn | 1991-0088 |
| language | English |
| last_indexed | 2024-12-10T20:30:25Z |
| publishDate | 2015-01-01 |
| publisher | Bangladesh Pharmacological Society |
| record_format | Article |
| series | Bangladesh Journal of Pharmacology |
| spelling | doaj.art-f3ef031272fc435ca0f1715af5af719c2022-12-22T01:34:43ZengBangladesh Pharmacological SocietyBangladesh Journal of Pharmacology1991-00882015-01-01101Daucosterol derived from Cordyceps (a Traditional Chinese Medicine) as a possible lead compound for allergic transfusion reactionsJian Yang0Ji-Xia Li1Zhe Song2Xi-Yan Xia3Yantai Blood Center, Yantai, Shandong 264000Department of Clinical Laboratory, Yantaishan Hospital, Yantai, Shandong 264000Department of Quality Control, Yantai Blood Center, Yantai, Shandong 264000Jinan Nursing Vocational College, Jinan Shandong 250000Allergic transfusion reaction is an anomaly that develops within several hours of transfusion which is usually treated by antihistamine. In the present study, we are looking into daucosterol, an extract of Traditional Chinese Medicine (TCM) Cordyceps, as a potential inhibitor of histidine decarboxylase. The approach of molecular docking and Molecular Dynamics Simulation (MDS) on a traditional anti-inflammatory Chinese medicine gave an atomic insight of the inhibition. The daucosterol was binding with a ?G of -3.17 Kcal/mol, to inhibit histamine synthesis by binding to histidine decarboxylase, possibly via the flexible catalytic loop. Such inhibitors that were designed to block the flexibility of the catalytic loop are potential candidates for further drug development program.https://www.banglajol.info/index.php/BJP/article/view/20498Allergic Transfusion ReactionsTraditional Chinese MedicineAnti HistamineHistidine decarboxylaseMolecular Dynamics Simulation |
| spellingShingle | Jian Yang Ji-Xia Li Zhe Song Xi-Yan Xia Daucosterol derived from Cordyceps (a Traditional Chinese Medicine) as a possible lead compound for allergic transfusion reactions Bangladesh Journal of Pharmacology Allergic Transfusion Reactions Traditional Chinese Medicine Anti Histamine Histidine decarboxylase Molecular Dynamics Simulation |
| title | Daucosterol derived from Cordyceps (a Traditional Chinese Medicine) as a possible lead compound for allergic transfusion reactions |
| title_full | Daucosterol derived from Cordyceps (a Traditional Chinese Medicine) as a possible lead compound for allergic transfusion reactions |
| title_fullStr | Daucosterol derived from Cordyceps (a Traditional Chinese Medicine) as a possible lead compound for allergic transfusion reactions |
| title_full_unstemmed | Daucosterol derived from Cordyceps (a Traditional Chinese Medicine) as a possible lead compound for allergic transfusion reactions |
| title_short | Daucosterol derived from Cordyceps (a Traditional Chinese Medicine) as a possible lead compound for allergic transfusion reactions |
| title_sort | daucosterol derived from cordyceps a traditional chinese medicine as a possible lead compound for allergic transfusion reactions |
| topic | Allergic Transfusion Reactions Traditional Chinese Medicine Anti Histamine Histidine decarboxylase Molecular Dynamics Simulation |
| url | https://www.banglajol.info/index.php/BJP/article/view/20498 |
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