Spontaneous pregnancy after tracking ovulation during menstruation: A case report of a woman with premature ovarian insufficiency and repeated failure of in vitro fertilization
The diagnosis of premature ovarian insufficiency (POI) is devastating in women of reproductive age because of the small chance of spontaneous pregnancy. Here, we report a very rare case with POI and repeated failure of in vitro fertilization (IVF) where the final result was natural fertilization fol...
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Frontiers Media S.A.
2022-12-01
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Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2022.994674/full |
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author | Ye He Ye He Ye He Wanlu Wang Wanlu Wang Wanlu Wang Chunmei Wu Wenwen Li Wenwen Li Wenwen Li Hongjiang Liu Hongjiang Liu Hongjiang Liu Zhaolian Wei Zhaolian Wei Zhaolian Wei |
author_facet | Ye He Ye He Ye He Wanlu Wang Wanlu Wang Wanlu Wang Chunmei Wu Wenwen Li Wenwen Li Wenwen Li Hongjiang Liu Hongjiang Liu Hongjiang Liu Zhaolian Wei Zhaolian Wei Zhaolian Wei |
author_sort | Ye He |
collection | DOAJ |
description | The diagnosis of premature ovarian insufficiency (POI) is devastating in women of reproductive age because of the small chance of spontaneous pregnancy. Here, we report a very rare case with POI and repeated failure of in vitro fertilization (IVF) where the final result was natural fertilization following guidance to have sexual intercourse during menstruation as ovulation was monitored. Estradiol valerate was used to increase the thickness of the endometrium and stop the menstrual bleeding. There was a serum level of 208.44 IU/L of human chorionic gonadotropin (HCG) 14 days after the ovulation. Later, a series of transvaginal ultrasounds also indicated a normal-appearing intra-uterine pregnancy. A healthy baby girl was delivered at term by means of cesarean section. Our report suggested that although the chance of spontaneous pregnancy is relatively low in patients with POI with repeated IVF failures, as long as ovulation does occur, even if it happens during menstruation, natural pregnancy is still worth trying with a series of proper and personalized treatments. |
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language | English |
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publishDate | 2022-12-01 |
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series | Frontiers in Medicine |
spelling | doaj.art-f3f0f5f265494d7cb092dccb3203e04b2022-12-22T02:57:13ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2022-12-01910.3389/fmed.2022.994674994674Spontaneous pregnancy after tracking ovulation during menstruation: A case report of a woman with premature ovarian insufficiency and repeated failure of in vitro fertilizationYe He0Ye He1Ye He2Wanlu Wang3Wanlu Wang4Wanlu Wang5Chunmei Wu6Wenwen Li7Wenwen Li8Wenwen Li9Hongjiang Liu10Hongjiang Liu11Hongjiang Liu12Zhaolian Wei13Zhaolian Wei14Zhaolian Wei15Department of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, Hefei, ChinaNHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract (Anhui Medical University), Hefei, ChinaKey Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People's Republic of China, Hefei, ChinaDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, Hefei, ChinaNHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract (Anhui Medical University), Hefei, ChinaKey Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People's Republic of China, Hefei, ChinaDepartment of Obstetrics and Gynecology, The People's Hospital of Huaibei City, Huaibei, ChinaDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, Hefei, ChinaNHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract (Anhui Medical University), Hefei, ChinaKey Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People's Republic of China, Hefei, ChinaDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, Hefei, ChinaNHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract (Anhui Medical University), Hefei, ChinaKey Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People's Republic of China, Hefei, ChinaDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, Hefei, ChinaNHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract (Anhui Medical University), Hefei, ChinaKey Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People's Republic of China, Hefei, ChinaThe diagnosis of premature ovarian insufficiency (POI) is devastating in women of reproductive age because of the small chance of spontaneous pregnancy. Here, we report a very rare case with POI and repeated failure of in vitro fertilization (IVF) where the final result was natural fertilization following guidance to have sexual intercourse during menstruation as ovulation was monitored. Estradiol valerate was used to increase the thickness of the endometrium and stop the menstrual bleeding. There was a serum level of 208.44 IU/L of human chorionic gonadotropin (HCG) 14 days after the ovulation. Later, a series of transvaginal ultrasounds also indicated a normal-appearing intra-uterine pregnancy. A healthy baby girl was delivered at term by means of cesarean section. Our report suggested that although the chance of spontaneous pregnancy is relatively low in patients with POI with repeated IVF failures, as long as ovulation does occur, even if it happens during menstruation, natural pregnancy is still worth trying with a series of proper and personalized treatments.https://www.frontiersin.org/articles/10.3389/fmed.2022.994674/fullpremature ovarian insufficiencyrepeated failure of in-vitro fertilizationspontaneous pregnancyovulation during menstruationlive birth |
spellingShingle | Ye He Ye He Ye He Wanlu Wang Wanlu Wang Wanlu Wang Chunmei Wu Wenwen Li Wenwen Li Wenwen Li Hongjiang Liu Hongjiang Liu Hongjiang Liu Zhaolian Wei Zhaolian Wei Zhaolian Wei Spontaneous pregnancy after tracking ovulation during menstruation: A case report of a woman with premature ovarian insufficiency and repeated failure of in vitro fertilization Frontiers in Medicine premature ovarian insufficiency repeated failure of in-vitro fertilization spontaneous pregnancy ovulation during menstruation live birth |
title | Spontaneous pregnancy after tracking ovulation during menstruation: A case report of a woman with premature ovarian insufficiency and repeated failure of in vitro fertilization |
title_full | Spontaneous pregnancy after tracking ovulation during menstruation: A case report of a woman with premature ovarian insufficiency and repeated failure of in vitro fertilization |
title_fullStr | Spontaneous pregnancy after tracking ovulation during menstruation: A case report of a woman with premature ovarian insufficiency and repeated failure of in vitro fertilization |
title_full_unstemmed | Spontaneous pregnancy after tracking ovulation during menstruation: A case report of a woman with premature ovarian insufficiency and repeated failure of in vitro fertilization |
title_short | Spontaneous pregnancy after tracking ovulation during menstruation: A case report of a woman with premature ovarian insufficiency and repeated failure of in vitro fertilization |
title_sort | spontaneous pregnancy after tracking ovulation during menstruation a case report of a woman with premature ovarian insufficiency and repeated failure of in vitro fertilization |
topic | premature ovarian insufficiency repeated failure of in-vitro fertilization spontaneous pregnancy ovulation during menstruation live birth |
url | https://www.frontiersin.org/articles/10.3389/fmed.2022.994674/full |
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