Malt lymphoma of the parotid salivary gland
Background. Mucosa-associated lymphoid tissue (MALT) lymphoma was described for the first time in 1983 by Isaacson and Wright. It was classified into extranodal non-Hodkin's lymphomas of B-cell lymphocytes of the marginal zone of reactive lymphe follicles. It is characterized by both hyperplasi...
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| Format: | Article |
| Language: | English |
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Military Health Department, Ministry of Defance, Serbia
2007-01-01
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| Series: | Vojnosanitetski Pregled |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2007/0042-84500701053K.pdf |
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| author | Krasić Dragan Radović Predrag Burić Nikola Ćosić Andrija Katić Vuka |
| author_facet | Krasić Dragan Radović Predrag Burić Nikola Ćosić Andrija Katić Vuka |
| author_sort | Krasić Dragan |
| collection | DOAJ |
| description | Background. Mucosa-associated lymphoid tissue (MALT) lymphoma was described for the first time in 1983 by Isaacson and Wright. It was classified into extranodal non-Hodkin's lymphomas of B-cell lymphocytes of the marginal zone of reactive lymphe follicles. It is characterized by both hyperplasia and colonization of plasmocytic, centrocytoid and monocytoid cells, by the infiltration of interfollicular and parafollicular parts of interstitium, as well as by the invasion of clusters of neoplastic lymphoid cells of the glandular epithelium, forming the pathognomic lymphoepithelial MALT limphoma lesions. Case report. In this paper we presented the two female patients, 59 and 75 years of age, with MALT lymphomas, associated with Miculicz's and Sjögren's syndromes. The paper also underlined rather manymonth- long, indolent clinical course, evalution of both tumors, massive in size, as well as two-sided localization in the case of the Miculicz's syndrome. After the subtotal parotidectomy, using conservation of nerve facialis, the tissue blocks were fixed in 10% formaldehyde. The paraffine sections were stained by routine histochemical and an immunohistochemical method by using monoclonal antibodies for both B-cell and T-cell lymphomas, due to the verification of lymphoepithelial lesions. The MALT lymphoma diagnosis was based on the histological criteria and confirmed by an immunohistochemical method. After the surgical therapy accompanied by chemotherapy, the patients were controlled at regular intervals, and residual MALT lymphoma did not appear. Conclusion. MALT lymphoma is a rare tumor of the salivary glands, with the most frequent localization in the parotide gland. It had a slow clinical course, without metastases in both patients. The diagnosis was made pathohistologically and confirmed immunohistochemically. The surgical therapy was accompained by adjuvant chemotherapy. |
| first_indexed | 2024-12-12T09:07:43Z |
| format | Article |
| id | doaj.art-f3f42370108d4875844c67556a1cffdc |
| institution | Directory Open Access Journal |
| issn | 0042-8450 |
| language | English |
| last_indexed | 2024-12-12T09:07:43Z |
| publishDate | 2007-01-01 |
| publisher | Military Health Department, Ministry of Defance, Serbia |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj.art-f3f42370108d4875844c67556a1cffdc2022-12-22T00:29:38ZengMilitary Health Department, Ministry of Defance, SerbiaVojnosanitetski Pregled0042-84502007-01-01641535710.2298/VSP0701053KMalt lymphoma of the parotid salivary glandKrasić DraganRadović PredragBurić NikolaĆosić AndrijaKatić VukaBackground. Mucosa-associated lymphoid tissue (MALT) lymphoma was described for the first time in 1983 by Isaacson and Wright. It was classified into extranodal non-Hodkin's lymphomas of B-cell lymphocytes of the marginal zone of reactive lymphe follicles. It is characterized by both hyperplasia and colonization of plasmocytic, centrocytoid and monocytoid cells, by the infiltration of interfollicular and parafollicular parts of interstitium, as well as by the invasion of clusters of neoplastic lymphoid cells of the glandular epithelium, forming the pathognomic lymphoepithelial MALT limphoma lesions. Case report. In this paper we presented the two female patients, 59 and 75 years of age, with MALT lymphomas, associated with Miculicz's and Sjögren's syndromes. The paper also underlined rather manymonth- long, indolent clinical course, evalution of both tumors, massive in size, as well as two-sided localization in the case of the Miculicz's syndrome. After the subtotal parotidectomy, using conservation of nerve facialis, the tissue blocks were fixed in 10% formaldehyde. The paraffine sections were stained by routine histochemical and an immunohistochemical method by using monoclonal antibodies for both B-cell and T-cell lymphomas, due to the verification of lymphoepithelial lesions. The MALT lymphoma diagnosis was based on the histological criteria and confirmed by an immunohistochemical method. After the surgical therapy accompanied by chemotherapy, the patients were controlled at regular intervals, and residual MALT lymphoma did not appear. Conclusion. MALT lymphoma is a rare tumor of the salivary glands, with the most frequent localization in the parotide gland. It had a slow clinical course, without metastases in both patients. The diagnosis was made pathohistologically and confirmed immunohistochemically. The surgical therapy was accompained by adjuvant chemotherapy.http://www.doiserbia.nb.rs/img/doi/0042-8450/2007/0042-84500701053K.pdflymphomamucosa-associated lymphoid tissuesalivary gland neoplasmsoral surgical proceduresimmunohistochemistryantineoplastic combined chemotherapy protocolsradiotherapy |
| spellingShingle | Krasić Dragan Radović Predrag Burić Nikola Ćosić Andrija Katić Vuka Malt lymphoma of the parotid salivary gland Vojnosanitetski Pregled lymphoma mucosa-associated lymphoid tissue salivary gland neoplasms oral surgical procedures immunohistochemistry antineoplastic combined chemotherapy protocols radiotherapy |
| title | Malt lymphoma of the parotid salivary gland |
| title_full | Malt lymphoma of the parotid salivary gland |
| title_fullStr | Malt lymphoma of the parotid salivary gland |
| title_full_unstemmed | Malt lymphoma of the parotid salivary gland |
| title_short | Malt lymphoma of the parotid salivary gland |
| title_sort | malt lymphoma of the parotid salivary gland |
| topic | lymphoma mucosa-associated lymphoid tissue salivary gland neoplasms oral surgical procedures immunohistochemistry antineoplastic combined chemotherapy protocols radiotherapy |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2007/0042-84500701053K.pdf |
| work_keys_str_mv | AT krasicdragan maltlymphomaoftheparotidsalivarygland AT radovicpredrag maltlymphomaoftheparotidsalivarygland AT buricnikola maltlymphomaoftheparotidsalivarygland AT cosicandrija maltlymphomaoftheparotidsalivarygland AT katicvuka maltlymphomaoftheparotidsalivarygland |