ESTRIOL IN FUNCTIONAL MODULATION OF REGULATORY LYMPHOCYTES IN MULTIPLE SCLEROSIS
We studied effects of estriol (E3), at the doses corresponding to the I and III trimesters of pregnancy,upon expression of functional markers on T-regulatory (Treg) and Th17-producing (Th17) lymphocytes, aswell as the production of relevant cytokines by the cells of patients with multiple sclerosis...
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| Format: | Article |
| Language: | Russian |
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St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2014-07-01
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| Series: | Медицинская иммунология |
| Subjects: | |
| Online Access: | https://www.mimmun.ru/mimmun/article/view/23 |
| _version_ | 1826534419722141696 |
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| author | I. V. Nekrasova S. V. Shirshev I. Yu. Danchenko |
| author_facet | I. V. Nekrasova S. V. Shirshev I. Yu. Danchenko |
| author_sort | I. V. Nekrasova |
| collection | DOAJ |
| description | We studied effects of estriol (E3), at the doses corresponding to the I and III trimesters of pregnancy,upon expression of functional markers on T-regulatory (Treg) and Th17-producing (Th17) lymphocytes, aswell as the production of relevant cytokines by the cells of patients with multiple sclerosis (MS), as comparedwith healthy donors. It was found that the levels of CD4+FoxP3+CTLA-4+ (Treg) lymphocytes in MS patientswere initially lower than those of healthy donors. Percentages of CD4+RORγt+IL-17A+ (Th17) lymphocytesdid not significantly differ from those in healthy donors, still showing a tendency for increase. Baseline levelsof IL-17 and IL-6 in cell culture supernates of MS patients were higher than in healthy donors, along withreduced contents of the anti-inflammatory IL-10 cytokine. Percentage of Tregs was increased under theinfluence of estriol, whereas Th17 proportion was diminished. These hormonal effects upon lymphocyteswere reproducible both for healthy donors, and MS patients. Moreover, estriol stimulated IL-10 productionand inhibited secretion of IL-6 and IL-17. Therefore, a sufficient release of MS symptoms observed duringpregnancy may be explained by influence of estriol, thus extending opportunities for rational use of this steroidhormone in MS treatment |
| first_indexed | 2024-03-08T05:52:10Z |
| format | Article |
| id | doaj.art-f3f663ba9e7c488fb106971d8a5966d6 |
| institution | Directory Open Access Journal |
| issn | 1563-0625 2313-741X |
| language | Russian |
| last_indexed | 2025-03-14T02:22:44Z |
| publishDate | 2014-07-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj.art-f3f663ba9e7c488fb106971d8a5966d62025-03-11T17:58:59ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2014-07-01161536010.15789/1563-0625-2014-1-53-6023ESTRIOL IN FUNCTIONAL MODULATION OF REGULATORY LYMPHOCYTES IN MULTIPLE SCLEROSISI. V. Nekrasova0S. V. Shirshev1I. Yu. Danchenko2Institute of Ecology and Genetics of Microorganisms, Ural Branch, Russian Academy of Sciences, PermInstitute of Ecology and Genetics of Microorganisms, Ural Branch, Russian Academy of Sciences, PermPerm State Medical Academy, PermWe studied effects of estriol (E3), at the doses corresponding to the I and III trimesters of pregnancy,upon expression of functional markers on T-regulatory (Treg) and Th17-producing (Th17) lymphocytes, aswell as the production of relevant cytokines by the cells of patients with multiple sclerosis (MS), as comparedwith healthy donors. It was found that the levels of CD4+FoxP3+CTLA-4+ (Treg) lymphocytes in MS patientswere initially lower than those of healthy donors. Percentages of CD4+RORγt+IL-17A+ (Th17) lymphocytesdid not significantly differ from those in healthy donors, still showing a tendency for increase. Baseline levelsof IL-17 and IL-6 in cell culture supernates of MS patients were higher than in healthy donors, along withreduced contents of the anti-inflammatory IL-10 cytokine. Percentage of Tregs was increased under theinfluence of estriol, whereas Th17 proportion was diminished. These hormonal effects upon lymphocyteswere reproducible both for healthy donors, and MS patients. Moreover, estriol stimulated IL-10 productionand inhibited secretion of IL-6 and IL-17. Therefore, a sufficient release of MS symptoms observed duringpregnancy may be explained by influence of estriol, thus extending opportunities for rational use of this steroidhormone in MS treatmenthttps://www.mimmun.ru/mimmun/article/view/23multiple sclerosisestriolt regulatory lymphocytesth17 lymphocytescytokines |
| spellingShingle | I. V. Nekrasova S. V. Shirshev I. Yu. Danchenko ESTRIOL IN FUNCTIONAL MODULATION OF REGULATORY LYMPHOCYTES IN MULTIPLE SCLEROSIS Медицинская иммунология multiple sclerosis estriol t regulatory lymphocytes th17 lymphocytes cytokines |
| title | ESTRIOL IN FUNCTIONAL MODULATION OF REGULATORY LYMPHOCYTES IN MULTIPLE SCLEROSIS |
| title_full | ESTRIOL IN FUNCTIONAL MODULATION OF REGULATORY LYMPHOCYTES IN MULTIPLE SCLEROSIS |
| title_fullStr | ESTRIOL IN FUNCTIONAL MODULATION OF REGULATORY LYMPHOCYTES IN MULTIPLE SCLEROSIS |
| title_full_unstemmed | ESTRIOL IN FUNCTIONAL MODULATION OF REGULATORY LYMPHOCYTES IN MULTIPLE SCLEROSIS |
| title_short | ESTRIOL IN FUNCTIONAL MODULATION OF REGULATORY LYMPHOCYTES IN MULTIPLE SCLEROSIS |
| title_sort | estriol in functional modulation of regulatory lymphocytes in multiple sclerosis |
| topic | multiple sclerosis estriol t regulatory lymphocytes th17 lymphocytes cytokines |
| url | https://www.mimmun.ru/mimmun/article/view/23 |
| work_keys_str_mv | AT ivnekrasova estriolinfunctionalmodulationofregulatorylymphocytesinmultiplesclerosis AT svshirshev estriolinfunctionalmodulationofregulatorylymphocytesinmultiplesclerosis AT iyudanchenko estriolinfunctionalmodulationofregulatorylymphocytesinmultiplesclerosis |