Eltrombopag as an Allosteric Inhibitor of the METTL3-14 Complex Affecting the m<sup>6</sup>A Methylation of RNA in Acute Myeloid Leukemia Cells

Eltrombopag as an Allosteric Inhibitor of the METTL3-14 Complex Affecting the m<sup>6</sup>A Methylation of RNA in Acute Myeloid Leukemia Cells

N<sup>6</sup>A-methyladenosine (m<sup>6</sup>A) post-transcriptional modification, the most abundant internal RNA modification, is catalyzed by the METTL3-14 methyltransferase complex. Recently, attention has been drawn to the METTL3-14 complex regarding its significant roles...

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Bibliographic Details
Main Authors: Je-Heon Lee, Namjeong Choi, Subin Kim, Mi Sun Jin, Haihong Shen, Yong-Chul Kim
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Pharmaceuticals
Subjects:
eltrombopag
METTL3-14
allosteric inhibitor
acute myeloid leukemia
Online Access:https://www.mdpi.com/1424-8247/15/4/440

Internet

https://www.mdpi.com/1424-8247/15/4/440

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