Alteration of circulating redox balance in coronavirus disease-19-induced acute respiratory distress syndrome
Abstract Background Mechanisms underpinning ARDS induced by COVID-19 are mostly immune-mediated, but need to be completely clarified. This study aimed to investigate redox balance in COVID-19 patients with ARDS, trying to recognize possible differences from typical ARDS related to the pathophysiolog...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-07-01
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| Series: | Journal of Intensive Care |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40560-023-00679-y |
| _version_ | 1797784800931610624 |
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| author | Francesco Bellanti Sławomir Kasperczyk Aleksandra Kasperczyk Michał Dobrakowski Gabriella Pacilli Giuseppina Vurchio Alessandro Maddalena Stefano Quiete Aurelio Lo Buglio Cristiano Capurso Gaetano Serviddio Gianluigi Vendemiale |
| author_facet | Francesco Bellanti Sławomir Kasperczyk Aleksandra Kasperczyk Michał Dobrakowski Gabriella Pacilli Giuseppina Vurchio Alessandro Maddalena Stefano Quiete Aurelio Lo Buglio Cristiano Capurso Gaetano Serviddio Gianluigi Vendemiale |
| author_sort | Francesco Bellanti |
| collection | DOAJ |
| description | Abstract Background Mechanisms underpinning ARDS induced by COVID-19 are mostly immune-mediated, but need to be completely clarified. This study aimed to investigate redox balance in COVID-19 patients with ARDS, trying to recognize possible differences from typical ARDS related to the pathophysiology of severe disease. Methods Patients affected by ARDS and positive for the SARS-CoV-2 virus (N = 40, COVID-19) were compared to ARDS patients negative to the molecular test (N = 42, No COVID-19). Circulating markers of redox balance were measured in serum and erythrocytes, and related to markers of inflammation and coagulability. Results No differences in serum markers of oxidative damage were found between both groups, but a reduction in total antioxidant status and serum ceruloplasmin level was observed in COVID-19 rather than No COVID-19 patients. Redox balance alterations were described in erythrocytes from COVID-19 with respect to No COVID-19 group, characterized by increased lipofuscin and malondialdehyde concentration, and reduced glutathione S-transferase and glutathione reductase activity. These markers were associated with circulating indexes of respiratory disease severity (Horowitz index and alveolar-to-arterial oxygen gradient), inflammation (interleukin-6 and interleukin-10), and hypercoagulability (D-dimer) in COVID-19 patients with ARDS. Conclusions ARDS caused by COVID-19 is sustained by impairment of redox balance, particularly in erythrocytes. This alteration is associated with the pro-inflammatory and pro-coagulant status which characterizes severe COVID-19. |
| first_indexed | 2024-03-13T00:45:03Z |
| format | Article |
| id | doaj.art-f3f87560f069490e9691225e2e7a7b34 |
| institution | Directory Open Access Journal |
| issn | 2052-0492 |
| language | English |
| last_indexed | 2024-03-13T00:45:03Z |
| publishDate | 2023-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Intensive Care |
| spelling | doaj.art-f3f87560f069490e9691225e2e7a7b342023-07-09T11:07:44ZengBMCJournal of Intensive Care2052-04922023-07-0111111110.1186/s40560-023-00679-yAlteration of circulating redox balance in coronavirus disease-19-induced acute respiratory distress syndromeFrancesco Bellanti0Sławomir Kasperczyk1Aleksandra Kasperczyk2Michał Dobrakowski3Gabriella Pacilli4Giuseppina Vurchio5Alessandro Maddalena6Stefano Quiete7Aurelio Lo Buglio8Cristiano Capurso9Gaetano Serviddio10Gianluigi Vendemiale11Department of Medical and Surgical Sciences, University of FoggiaDepartment of Biochemistry, School of Medicine with the Division of Dentistry in Zabrze, Medical University of SilesiaDepartment of Biochemistry, School of Medicine with the Division of Dentistry in Zabrze, Medical University of SilesiaDepartment of Biochemistry, School of Medicine with the Division of Dentistry in Zabrze, Medical University of SilesiaDepartment of Medical and Surgical Sciences, University of FoggiaDepartment of Medical and Surgical Sciences, University of FoggiaDepartment of Medical and Surgical Sciences, University of FoggiaDepartment of Medical and Surgical Sciences, University of FoggiaDepartment of Medical and Surgical Sciences, University of FoggiaDepartment of Medical and Surgical Sciences, University of FoggiaDepartment of Medical and Surgical Sciences, University of FoggiaDepartment of Medical and Surgical Sciences, University of FoggiaAbstract Background Mechanisms underpinning ARDS induced by COVID-19 are mostly immune-mediated, but need to be completely clarified. This study aimed to investigate redox balance in COVID-19 patients with ARDS, trying to recognize possible differences from typical ARDS related to the pathophysiology of severe disease. Methods Patients affected by ARDS and positive for the SARS-CoV-2 virus (N = 40, COVID-19) were compared to ARDS patients negative to the molecular test (N = 42, No COVID-19). Circulating markers of redox balance were measured in serum and erythrocytes, and related to markers of inflammation and coagulability. Results No differences in serum markers of oxidative damage were found between both groups, but a reduction in total antioxidant status and serum ceruloplasmin level was observed in COVID-19 rather than No COVID-19 patients. Redox balance alterations were described in erythrocytes from COVID-19 with respect to No COVID-19 group, characterized by increased lipofuscin and malondialdehyde concentration, and reduced glutathione S-transferase and glutathione reductase activity. These markers were associated with circulating indexes of respiratory disease severity (Horowitz index and alveolar-to-arterial oxygen gradient), inflammation (interleukin-6 and interleukin-10), and hypercoagulability (D-dimer) in COVID-19 patients with ARDS. Conclusions ARDS caused by COVID-19 is sustained by impairment of redox balance, particularly in erythrocytes. This alteration is associated with the pro-inflammatory and pro-coagulant status which characterizes severe COVID-19.https://doi.org/10.1186/s40560-023-00679-yAcute respiratory distress syndromeCOVID-19Respiratory failureRedox-dependent markersErythrocyte oxidative stressInflammation |
| spellingShingle | Francesco Bellanti Sławomir Kasperczyk Aleksandra Kasperczyk Michał Dobrakowski Gabriella Pacilli Giuseppina Vurchio Alessandro Maddalena Stefano Quiete Aurelio Lo Buglio Cristiano Capurso Gaetano Serviddio Gianluigi Vendemiale Alteration of circulating redox balance in coronavirus disease-19-induced acute respiratory distress syndrome Journal of Intensive Care Acute respiratory distress syndrome COVID-19 Respiratory failure Redox-dependent markers Erythrocyte oxidative stress Inflammation |
| title | Alteration of circulating redox balance in coronavirus disease-19-induced acute respiratory distress syndrome |
| title_full | Alteration of circulating redox balance in coronavirus disease-19-induced acute respiratory distress syndrome |
| title_fullStr | Alteration of circulating redox balance in coronavirus disease-19-induced acute respiratory distress syndrome |
| title_full_unstemmed | Alteration of circulating redox balance in coronavirus disease-19-induced acute respiratory distress syndrome |
| title_short | Alteration of circulating redox balance in coronavirus disease-19-induced acute respiratory distress syndrome |
| title_sort | alteration of circulating redox balance in coronavirus disease 19 induced acute respiratory distress syndrome |
| topic | Acute respiratory distress syndrome COVID-19 Respiratory failure Redox-dependent markers Erythrocyte oxidative stress Inflammation |
| url | https://doi.org/10.1186/s40560-023-00679-y |
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