Resistant potato starch supplementation reduces serum histamine levels in healthy adults with links to attenuated intestinal permeability
Histamine from our diet or gut microbes can trigger gastrointestinal disturbances, and resistant potato starch (RPS) has previously been shown to alleviate these symptoms while increasing levels of health-associated bacteria such as Akkermansia through unknown mechanisms. Post hoc exploratory metabo...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-09-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464623003407 |
| _version_ | 1797689006546223104 |
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| author | Jason R. Bush Jun Han Edward C. Deehan Scott V. Harding Madhura Maiya Joshua Baisley David Schibli David R. Goodlett |
| author_facet | Jason R. Bush Jun Han Edward C. Deehan Scott V. Harding Madhura Maiya Joshua Baisley David Schibli David R. Goodlett |
| author_sort | Jason R. Bush |
| collection | DOAJ |
| description | Histamine from our diet or gut microbes can trigger gastrointestinal disturbances, and resistant potato starch (RPS) has previously been shown to alleviate these symptoms while increasing levels of health-associated bacteria such as Akkermansia through unknown mechanisms. Post hoc exploratory metabolomic analysis of serum amino acid, amine, and carnitine metabolites in participants consuming 3.5 g/day RPS or placebo (n = 48) was performed using liquid chromatography-mass spectrometry to determine whether RPS positively influences histamine metabolism and related parameters. Histamine levels were significantly reduced by RPS treatment, but histamine-degrading enzyme products were unaffected by RPS. RPS also reduced histamine-secreting Haemophilus and Lactobacillus. Further, metabolites associated with intestinal permeability, including 5-hydroxylysine, acetylspermidine, and short- and medium-chain carnitines ratios, were significantly reduced by RPS treatment, suggesting decreased serum histamine might be related to enhanced gut barrier function. These metabolomic findings expand the value of supplementing the diet with RPS. |
| first_indexed | 2024-03-12T01:38:42Z |
| format | Article |
| id | doaj.art-f3f8813ef36b4637b228547a9c9501a1 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-03-12T01:38:42Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-f3f8813ef36b4637b228547a9c9501a12023-09-11T04:16:52ZengElsevierJournal of Functional Foods1756-46462023-09-01108105740Resistant potato starch supplementation reduces serum histamine levels in healthy adults with links to attenuated intestinal permeabilityJason R. Bush0Jun Han1Edward C. Deehan2Scott V. Harding3Madhura Maiya4Joshua Baisley5David Schibli6David R. Goodlett7MSP Starch Products Inc., Carberry, MB R0K 0H0, Canada; Corresponding author.Genome British Columbia Proteomics Centre, University of Victoria, Victoria, BC V8Z 7X8, Canada; Division of Medical Sciences, University of Victoria, Victoria, BC V8Z 7X8, CanadaDepartment of Food Science and Technology, University of Nebraska, Lincoln, NE 68588, USADepartment of Biochemistry, Memorial University of Newfoundland, St. John’s, NL A1C 5S7, CanadaDepartment of Kinesiology, University of Texas at Tyler, Tyler, TX 75799, USAClinical Design and Delivery, Nutrasource Pharmaceutical and Nutraceutical Services, Guelph, ON N1G 0B4, CanadaGenome British Columbia Proteomics Centre, University of Victoria, Victoria, BC V8Z 7X8, Canada; Division of Medical Sciences, University of Victoria, Victoria, BC V8Z 7X8, CanadaGenome British Columbia Proteomics Centre, University of Victoria, Victoria, BC V8Z 7X8, Canada; Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC V8Z 7X8, CanadaHistamine from our diet or gut microbes can trigger gastrointestinal disturbances, and resistant potato starch (RPS) has previously been shown to alleviate these symptoms while increasing levels of health-associated bacteria such as Akkermansia through unknown mechanisms. Post hoc exploratory metabolomic analysis of serum amino acid, amine, and carnitine metabolites in participants consuming 3.5 g/day RPS or placebo (n = 48) was performed using liquid chromatography-mass spectrometry to determine whether RPS positively influences histamine metabolism and related parameters. Histamine levels were significantly reduced by RPS treatment, but histamine-degrading enzyme products were unaffected by RPS. RPS also reduced histamine-secreting Haemophilus and Lactobacillus. Further, metabolites associated with intestinal permeability, including 5-hydroxylysine, acetylspermidine, and short- and medium-chain carnitines ratios, were significantly reduced by RPS treatment, suggesting decreased serum histamine might be related to enhanced gut barrier function. These metabolomic findings expand the value of supplementing the diet with RPS.http://www.sciencedirect.com/science/article/pii/S1756464623003407PrebioticResistant starchHistamineHydroxylysineIntestinal permeabilityPolyamine |
| spellingShingle | Jason R. Bush Jun Han Edward C. Deehan Scott V. Harding Madhura Maiya Joshua Baisley David Schibli David R. Goodlett Resistant potato starch supplementation reduces serum histamine levels in healthy adults with links to attenuated intestinal permeability Journal of Functional Foods Prebiotic Resistant starch Histamine Hydroxylysine Intestinal permeability Polyamine |
| title | Resistant potato starch supplementation reduces serum histamine levels in healthy adults with links to attenuated intestinal permeability |
| title_full | Resistant potato starch supplementation reduces serum histamine levels in healthy adults with links to attenuated intestinal permeability |
| title_fullStr | Resistant potato starch supplementation reduces serum histamine levels in healthy adults with links to attenuated intestinal permeability |
| title_full_unstemmed | Resistant potato starch supplementation reduces serum histamine levels in healthy adults with links to attenuated intestinal permeability |
| title_short | Resistant potato starch supplementation reduces serum histamine levels in healthy adults with links to attenuated intestinal permeability |
| title_sort | resistant potato starch supplementation reduces serum histamine levels in healthy adults with links to attenuated intestinal permeability |
| topic | Prebiotic Resistant starch Histamine Hydroxylysine Intestinal permeability Polyamine |
| url | http://www.sciencedirect.com/science/article/pii/S1756464623003407 |
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