The effects of nutrition bio-shield superfood powder on immune system function: A clinical trial study among patients with COVID-19
The present study aimed to evaluate the effects of Nutrition Bio-shield Superfood (NBS) powder on the immune system function and clinical manifestations in patients with COVID-19. We compare the effects of NBS powder on the immune system function and clinical manifestations among two different group...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.919402/full |
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| author | Farid Azizi Jalilian Farid Azizi Jalilian Gheisar Keshavarz Salman Khazaei Manije Nezamdoost Seyed Hamid Hashemi Mojgan Mamani Nastaran Ansari Razieh Amini Aref Khalkhali Arghavan Keshavarz Erfan Ayubi Maryam Fazeli Rashid Heidari Moghadam Saeid Alizadeh Behzad Pourhossein Ali Teimouri Fariba Keramat Sajad Karampour Mohammadreza Khakzad |
| author_facet | Farid Azizi Jalilian Farid Azizi Jalilian Gheisar Keshavarz Salman Khazaei Manije Nezamdoost Seyed Hamid Hashemi Mojgan Mamani Nastaran Ansari Razieh Amini Aref Khalkhali Arghavan Keshavarz Erfan Ayubi Maryam Fazeli Rashid Heidari Moghadam Saeid Alizadeh Behzad Pourhossein Ali Teimouri Fariba Keramat Sajad Karampour Mohammadreza Khakzad |
| author_sort | Farid Azizi Jalilian |
| collection | DOAJ |
| description | The present study aimed to evaluate the effects of Nutrition Bio-shield Superfood (NBS) powder on the immune system function and clinical manifestations in patients with COVID-19. We compare the effects of NBS powder on the immune system function and clinical manifestations among two different groups: 1) intervention group receiving standard treatment scheduled according to treatment guidelines plus NBS powder, and 2) control group receiving only the same standard treatment. The serum levels of IL-2, IL-6, IL-17, IFNγ, and TNFα were determined after four weeks of treatment by specific ELISA kits according to the manufacturer’s instructions. Finally, the level of immune system stimulation and inflammatory markers were compared at baseline and after intervention in both groups. Data were analyzed using SPSS (version 22). A p-value of ≤ 0.05 was set as significant. A total of 47 patients with COVID-19 (24 patients in the intervention group and 23 patients in the control group) were included in this study. Results showed that the differences in the mean decrease of IL-2, IL-6, and TNF-α in the intervention group in comparison to the control group were 0.93, 10.28, and 8.11 pg/ml, respectively (P<0.001). On the other hand, there was no difference in IL-17, IFNγ, monocytes, eosinophil, and other inflammatory indices between the intervention and control groups. Although NBS powder was able to significantly decrease the levels of some proinflammatory cytokines in patients with COVID-19, however, it is noteworthy that the course of the disease was to large part unaffected by NBS power and there was a reduction independent of treatment. The present study indicates that NBS powder could provide a beneficial anti-inflammatory effect in patients with COVID-19. Hence, NBS in treating patients with COVID-19 shows promise as an adjuvant to the current standard antiviral treatment of such patients.Clinical Trial Registrationhttps://www.irct.ir, identifier IRCT20200426047206N1. |
| first_indexed | 2024-04-11T21:07:21Z |
| format | Article |
| id | doaj.art-f3fa6ae8c20a4398adf04fba38a6bbab |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-11T21:07:21Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-f3fa6ae8c20a4398adf04fba38a6bbab2022-12-22T04:03:15ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-08-011310.3389/fimmu.2022.919402919402The effects of nutrition bio-shield superfood powder on immune system function: A clinical trial study among patients with COVID-19Farid Azizi Jalilian0Farid Azizi Jalilian1Gheisar Keshavarz2Salman Khazaei3Manije Nezamdoost4Seyed Hamid Hashemi5Mojgan Mamani6Nastaran Ansari7Razieh Amini8Aref Khalkhali9Arghavan Keshavarz10Erfan Ayubi11Maryam Fazeli12Rashid Heidari Moghadam13Saeid Alizadeh14Behzad Pourhossein15Ali Teimouri16Fariba Keramat17Sajad Karampour18Mohammadreza Khakzad19Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, IranDepartment of Medical Virology, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, IranDepartment of Internal Medicine, Ilam University of Medical Sciences, Ilam, IranResearch Center for Health Sciences, Hamadan University of Medical Sciences, Hamadan, IranDepartment of Infectious Disease, Farabi Hospital, Iranian Social Security Organization, Mashhad, IranDepartment of Infectious Disease, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, IranDepartment of Infectious Disease, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, IranDepartment of Medical Virology, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, IranResearch Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, IranNBS Organic Company, Istanbul, TurkeyFaculty of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, IranSocial Determinants of Health Research Center, Hamadan University of Medical Sciences, Hamadan, IranDepartment of Medical Virology, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, IranResearch Center for Health Sciences, Hamadan University of Medical Sciences, Hamadan, Iran0Radiology Department of Sina Hospital, Hamadan, IranDepartment of Medical Virology, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, IranDepartment of Medical Virology, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, IranDepartment of Infectious Disease, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran1Department of Virology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran2Department of Immunology, Mashhad Branch, Islamic Azad University, Mashhad, IranThe present study aimed to evaluate the effects of Nutrition Bio-shield Superfood (NBS) powder on the immune system function and clinical manifestations in patients with COVID-19. We compare the effects of NBS powder on the immune system function and clinical manifestations among two different groups: 1) intervention group receiving standard treatment scheduled according to treatment guidelines plus NBS powder, and 2) control group receiving only the same standard treatment. The serum levels of IL-2, IL-6, IL-17, IFNγ, and TNFα were determined after four weeks of treatment by specific ELISA kits according to the manufacturer’s instructions. Finally, the level of immune system stimulation and inflammatory markers were compared at baseline and after intervention in both groups. Data were analyzed using SPSS (version 22). A p-value of ≤ 0.05 was set as significant. A total of 47 patients with COVID-19 (24 patients in the intervention group and 23 patients in the control group) were included in this study. Results showed that the differences in the mean decrease of IL-2, IL-6, and TNF-α in the intervention group in comparison to the control group were 0.93, 10.28, and 8.11 pg/ml, respectively (P<0.001). On the other hand, there was no difference in IL-17, IFNγ, monocytes, eosinophil, and other inflammatory indices between the intervention and control groups. Although NBS powder was able to significantly decrease the levels of some proinflammatory cytokines in patients with COVID-19, however, it is noteworthy that the course of the disease was to large part unaffected by NBS power and there was a reduction independent of treatment. The present study indicates that NBS powder could provide a beneficial anti-inflammatory effect in patients with COVID-19. Hence, NBS in treating patients with COVID-19 shows promise as an adjuvant to the current standard antiviral treatment of such patients.Clinical Trial Registrationhttps://www.irct.ir, identifier IRCT20200426047206N1.https://www.frontiersin.org/articles/10.3389/fimmu.2022.919402/fullnutrition bio-safety powderimmunity system functionCOVID-19ELISA - enzyme-linked immunosorbent assayIran |
| spellingShingle | Farid Azizi Jalilian Farid Azizi Jalilian Gheisar Keshavarz Salman Khazaei Manije Nezamdoost Seyed Hamid Hashemi Mojgan Mamani Nastaran Ansari Razieh Amini Aref Khalkhali Arghavan Keshavarz Erfan Ayubi Maryam Fazeli Rashid Heidari Moghadam Saeid Alizadeh Behzad Pourhossein Ali Teimouri Fariba Keramat Sajad Karampour Mohammadreza Khakzad The effects of nutrition bio-shield superfood powder on immune system function: A clinical trial study among patients with COVID-19 Frontiers in Immunology nutrition bio-safety powder immunity system function COVID-19 ELISA - enzyme-linked immunosorbent assay Iran |
| title | The effects of nutrition bio-shield superfood powder on immune system function: A clinical trial study among patients with COVID-19 |
| title_full | The effects of nutrition bio-shield superfood powder on immune system function: A clinical trial study among patients with COVID-19 |
| title_fullStr | The effects of nutrition bio-shield superfood powder on immune system function: A clinical trial study among patients with COVID-19 |
| title_full_unstemmed | The effects of nutrition bio-shield superfood powder on immune system function: A clinical trial study among patients with COVID-19 |
| title_short | The effects of nutrition bio-shield superfood powder on immune system function: A clinical trial study among patients with COVID-19 |
| title_sort | effects of nutrition bio shield superfood powder on immune system function a clinical trial study among patients with covid 19 |
| topic | nutrition bio-safety powder immunity system function COVID-19 ELISA - enzyme-linked immunosorbent assay Iran |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.919402/full |
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