Association between GRIN3A gene polymorphism in Kawasaki disease and coronary artery aneurysms in Taiwanese children.
Kawasaki disease (KD) is pediatric systemic vasculitis with the classic complication of coronary artery aneurysm (CAA). It is the leading cause of acquired cardiovascular diseases in children. Some severe cases present with multi-organ involvement or neurological dysfunction. To identify the role of...
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| Language: | English |
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Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3838481?pdf=render |
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| author | Ying-Ju Lin Jeng-Sheng Chang Xiang Liu Chien-Hui Hung Ting-Hsu Lin Shao-Mei Huang Kuan-Teh Jeang Chia-Yen Chen Chiu-Chu Liao Cheng-Wen Lin Chih-Ho Lai Ni Tien Yu-Ching Lan Mao-Wang Ho Wen-Kuei Chien Jin-Hua Chen Yu-Chuen Huang Hsinyi Tsang Jer-Yuarn Wu Chien-Hsiun Chen Li-Ching Chang Fuu-Jen Tsai |
| author_facet | Ying-Ju Lin Jeng-Sheng Chang Xiang Liu Chien-Hui Hung Ting-Hsu Lin Shao-Mei Huang Kuan-Teh Jeang Chia-Yen Chen Chiu-Chu Liao Cheng-Wen Lin Chih-Ho Lai Ni Tien Yu-Ching Lan Mao-Wang Ho Wen-Kuei Chien Jin-Hua Chen Yu-Chuen Huang Hsinyi Tsang Jer-Yuarn Wu Chien-Hsiun Chen Li-Ching Chang Fuu-Jen Tsai |
| author_sort | Ying-Ju Lin |
| collection | DOAJ |
| description | Kawasaki disease (KD) is pediatric systemic vasculitis with the classic complication of coronary artery aneurysm (CAA). It is the leading cause of acquired cardiovascular diseases in children. Some severe cases present with multi-organ involvement or neurological dysfunction. To identify the role of the glutamate receptor, ionotropic, N-methyl-d-aspartate 3A (GRIN3A) in KD, we investigated genetic variations in GRIN3A in a Taiwanese cohort of 262 KD patients (76 with and 186 without CAA complications). We used univariate and multivariate regression analyses to identify the associations between clinical characteristics and GRIN3A genetic variations in KD. According to univariate regression analysis, CAA formation in KD was significantly associated with fever duration (p < 0.0001), first Intravenous immunoglobulin (IVIG) used (days after day one of fever) (p < 0.0001), and the GRIN3A (rs7849782) genetic variant (p < 0.001). KD patients with GG+GC genotype showed a lower rate of developing CAA (GG+GC genotype: odds ratio = 0.26; 95% CI = 0.14-0.46). Significant associations were identified between KD with CAA complication and the GRIN3A (rs7849782) genetic variant by using multivariate regression analysis. Specifically, significant correlations were observed between KD with CAA complications and the presence of GG+GC genotypes for the GRIN3A rs7849782 single-nucleotide polymorphism (full model: odds ratio = 0.25; 95% CI = 0.14-0.46). Our results suggest that a polymorphism of the GRIN3A gene may play a role in KD pathogenesis. |
| first_indexed | 2024-12-21T14:14:00Z |
| format | Article |
| id | doaj.art-f3fa97890762420d9189766b94c28431 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-21T14:14:00Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-f3fa97890762420d9189766b94c284312022-12-21T19:00:58ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-01811e8138410.1371/journal.pone.0081384Association between GRIN3A gene polymorphism in Kawasaki disease and coronary artery aneurysms in Taiwanese children.Ying-Ju LinJeng-Sheng ChangXiang LiuChien-Hui HungTing-Hsu LinShao-Mei HuangKuan-Teh JeangChia-Yen ChenChiu-Chu LiaoCheng-Wen LinChih-Ho LaiNi TienYu-Ching LanMao-Wang HoWen-Kuei ChienJin-Hua ChenYu-Chuen HuangHsinyi TsangJer-Yuarn WuChien-Hsiun ChenLi-Ching ChangFuu-Jen TsaiKawasaki disease (KD) is pediatric systemic vasculitis with the classic complication of coronary artery aneurysm (CAA). It is the leading cause of acquired cardiovascular diseases in children. Some severe cases present with multi-organ involvement or neurological dysfunction. To identify the role of the glutamate receptor, ionotropic, N-methyl-d-aspartate 3A (GRIN3A) in KD, we investigated genetic variations in GRIN3A in a Taiwanese cohort of 262 KD patients (76 with and 186 without CAA complications). We used univariate and multivariate regression analyses to identify the associations between clinical characteristics and GRIN3A genetic variations in KD. According to univariate regression analysis, CAA formation in KD was significantly associated with fever duration (p < 0.0001), first Intravenous immunoglobulin (IVIG) used (days after day one of fever) (p < 0.0001), and the GRIN3A (rs7849782) genetic variant (p < 0.001). KD patients with GG+GC genotype showed a lower rate of developing CAA (GG+GC genotype: odds ratio = 0.26; 95% CI = 0.14-0.46). Significant associations were identified between KD with CAA complication and the GRIN3A (rs7849782) genetic variant by using multivariate regression analysis. Specifically, significant correlations were observed between KD with CAA complications and the presence of GG+GC genotypes for the GRIN3A rs7849782 single-nucleotide polymorphism (full model: odds ratio = 0.25; 95% CI = 0.14-0.46). Our results suggest that a polymorphism of the GRIN3A gene may play a role in KD pathogenesis.http://europepmc.org/articles/PMC3838481?pdf=render |
| spellingShingle | Ying-Ju Lin Jeng-Sheng Chang Xiang Liu Chien-Hui Hung Ting-Hsu Lin Shao-Mei Huang Kuan-Teh Jeang Chia-Yen Chen Chiu-Chu Liao Cheng-Wen Lin Chih-Ho Lai Ni Tien Yu-Ching Lan Mao-Wang Ho Wen-Kuei Chien Jin-Hua Chen Yu-Chuen Huang Hsinyi Tsang Jer-Yuarn Wu Chien-Hsiun Chen Li-Ching Chang Fuu-Jen Tsai Association between GRIN3A gene polymorphism in Kawasaki disease and coronary artery aneurysms in Taiwanese children. PLoS ONE |
| title | Association between GRIN3A gene polymorphism in Kawasaki disease and coronary artery aneurysms in Taiwanese children. |
| title_full | Association between GRIN3A gene polymorphism in Kawasaki disease and coronary artery aneurysms in Taiwanese children. |
| title_fullStr | Association between GRIN3A gene polymorphism in Kawasaki disease and coronary artery aneurysms in Taiwanese children. |
| title_full_unstemmed | Association between GRIN3A gene polymorphism in Kawasaki disease and coronary artery aneurysms in Taiwanese children. |
| title_short | Association between GRIN3A gene polymorphism in Kawasaki disease and coronary artery aneurysms in Taiwanese children. |
| title_sort | association between grin3a gene polymorphism in kawasaki disease and coronary artery aneurysms in taiwanese children |
| url | http://europepmc.org/articles/PMC3838481?pdf=render |
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