Comparative Analysis of APC Tumor Suppressor Protein Expression in Cancerous and Normal Colorectal Specimens by Immunohistochemistry
Background: APC is a tumor-suppressor protein. To evaluate the correlation between APC expression and pathogenesis of colorectal cancer, we investigated the expression of this protein in cancerous and normal colorectal tissues. Methods: APC expression was evaluated in 50 pairs of primary colorectal...
| Main Authors: | , |
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| Format: | Article |
| Language: | fas |
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Isfahan University of Medical Sciences
2011-12-01
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| Series: | مجله دانشکده پزشکی اصفهان |
| Subjects: | |
| Online Access: | http://jims.mui.ac.ir/index.php/jims/article/view/1284 |
| Summary: | Background: APC is a tumor-suppressor protein. To evaluate the correlation between APC expression and pathogenesis of colorectal cancer, we investigated the expression of this protein in cancerous and normal colorectal tissues.
Methods: APC expression was evaluated in 50 pairs of primary colorectal cancers and corresponding normal colorectal tissues using immunohistochemical staining on paraffin-embedded sections.
Findings: APC was expressed in all tissues. It was down-regulated in the colorectal cancer specimens compared with the matched normal tissues (P < 0.001).
Conclusion: APC expression may be a favorable biologic marker and a useful prognostic indicator in patients with colorectal cancer. |
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| ISSN: | 1027-7595 1735-854X |