Epidemiological Characteristics and Formation Mechanisms of Multidrug-Resistant Hypervirulent Klebsiella pneumoniae
Multi-drug resistance (MDR) and hypervirulence (hv) were exhibited by different well-separated Klebsiella pneumoniae lineages in the past, but their convergence clones—MDR-hypervirulent K. pneumoniae (HvKPs)—both highly pathogenic and resistant to most available antibiotics, have increasingly been r...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-11-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2020.581543/full |
| _version_ | 1818192644109500416 |
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| author | Miran Tang Xin Kong Jingchen Hao Jinbo Liu |
| author_facet | Miran Tang Xin Kong Jingchen Hao Jinbo Liu |
| author_sort | Miran Tang |
| collection | DOAJ |
| description | Multi-drug resistance (MDR) and hypervirulence (hv) were exhibited by different well-separated Klebsiella pneumoniae lineages in the past, but their convergence clones—MDR-hypervirulent K. pneumoniae (HvKPs)—both highly pathogenic and resistant to most available antibiotics, have increasingly been reported. In light of the clonal lineages and molecular characteristics of the studied MDR-HvKP strains found in the literature since 2014, this review discusses the epidemiology of MDR-HvKPs, in particular summarizing the three general aspects of plasmids-associated mechanisms underlying the formation of MDR-HvKPs clones: MDR-classic K. pneumoniae (cKPs) acquiring hv plasmids, hvKPs obtaining MDR plasmids, and the acquisition of hybrid plasmids harboring virulence and resistance determinants. A deeper understanding of epidemiological characteristics and possible formation mechanisms of MDR-HvKPs is greatly needed for the proper surveillance and management of this potential threat. |
| first_indexed | 2024-12-12T00:33:46Z |
| format | Article |
| id | doaj.art-f3fbeccdf66047778c231dd8240e4ea9 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-12-12T00:33:46Z |
| publishDate | 2020-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-f3fbeccdf66047778c231dd8240e4ea92022-12-22T00:44:25ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2020-11-011110.3389/fmicb.2020.581543581543Epidemiological Characteristics and Formation Mechanisms of Multidrug-Resistant Hypervirulent Klebsiella pneumoniaeMiran Tang0Xin Kong1Jingchen Hao2Jinbo Liu3Clinical Laboratory Department, Santai People’s Hospital, Mianyang, ChinaDepartment of Laboratory Medicine, Affiliated Hospital of Southwest Medical University, Luzhou, ChinaDepartment of Laboratory Medicine, Affiliated Hospital of Southwest Medical University, Luzhou, ChinaDepartment of Laboratory Medicine, Affiliated Hospital of Southwest Medical University, Luzhou, ChinaMulti-drug resistance (MDR) and hypervirulence (hv) were exhibited by different well-separated Klebsiella pneumoniae lineages in the past, but their convergence clones—MDR-hypervirulent K. pneumoniae (HvKPs)—both highly pathogenic and resistant to most available antibiotics, have increasingly been reported. In light of the clonal lineages and molecular characteristics of the studied MDR-HvKP strains found in the literature since 2014, this review discusses the epidemiology of MDR-HvKPs, in particular summarizing the three general aspects of plasmids-associated mechanisms underlying the formation of MDR-HvKPs clones: MDR-classic K. pneumoniae (cKPs) acquiring hv plasmids, hvKPs obtaining MDR plasmids, and the acquisition of hybrid plasmids harboring virulence and resistance determinants. A deeper understanding of epidemiological characteristics and possible formation mechanisms of MDR-HvKPs is greatly needed for the proper surveillance and management of this potential threat.https://www.frontiersin.org/articles/10.3389/fmicb.2020.581543/fullKlebsiella pneumoniaemulti-drug resistancehypervirulentepidemiologyformation mechanismplasmid |
| spellingShingle | Miran Tang Xin Kong Jingchen Hao Jinbo Liu Epidemiological Characteristics and Formation Mechanisms of Multidrug-Resistant Hypervirulent Klebsiella pneumoniae Frontiers in Microbiology Klebsiella pneumoniae multi-drug resistance hypervirulent epidemiology formation mechanism plasmid |
| title | Epidemiological Characteristics and Formation Mechanisms of Multidrug-Resistant Hypervirulent Klebsiella pneumoniae |
| title_full | Epidemiological Characteristics and Formation Mechanisms of Multidrug-Resistant Hypervirulent Klebsiella pneumoniae |
| title_fullStr | Epidemiological Characteristics and Formation Mechanisms of Multidrug-Resistant Hypervirulent Klebsiella pneumoniae |
| title_full_unstemmed | Epidemiological Characteristics and Formation Mechanisms of Multidrug-Resistant Hypervirulent Klebsiella pneumoniae |
| title_short | Epidemiological Characteristics and Formation Mechanisms of Multidrug-Resistant Hypervirulent Klebsiella pneumoniae |
| title_sort | epidemiological characteristics and formation mechanisms of multidrug resistant hypervirulent klebsiella pneumoniae |
| topic | Klebsiella pneumoniae multi-drug resistance hypervirulent epidemiology formation mechanism plasmid |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2020.581543/full |
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