Respiratory Training and Plasticity After Cervical Spinal Cord Injury
While spinal cord injuries (SCIs) result in a vast array of functional deficits, many of which are life threatening, the majority of SCIs are anatomically incomplete. Spared neural pathways contribute to functional and anatomical neuroplasticity that can occur spontaneously, or can be harnessed usin...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-09-01
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| Series: | Frontiers in Cellular Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fncel.2021.700821/full |
| _version_ | 1819063662623588352 |
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| author | Margo Randelman Margo Randelman Lyandysha V. Zholudeva Lyandysha V. Zholudeva Lyandysha V. Zholudeva Stéphane Vinit Michael A. Lane Michael A. Lane |
| author_facet | Margo Randelman Margo Randelman Lyandysha V. Zholudeva Lyandysha V. Zholudeva Lyandysha V. Zholudeva Stéphane Vinit Michael A. Lane Michael A. Lane |
| author_sort | Margo Randelman |
| collection | DOAJ |
| description | While spinal cord injuries (SCIs) result in a vast array of functional deficits, many of which are life threatening, the majority of SCIs are anatomically incomplete. Spared neural pathways contribute to functional and anatomical neuroplasticity that can occur spontaneously, or can be harnessed using rehabilitative, electrophysiological, or pharmacological strategies. With a focus on respiratory networks that are affected by cervical level SCI, the present review summarizes how non-invasive respiratory treatments can be used to harness this neuroplastic potential and enhance long-term recovery. Specific attention is given to “respiratory training” strategies currently used clinically (e.g., strength training) and those being developed through pre-clinical and early clinical testing [e.g., intermittent chemical stimulation via altering inhaled oxygen (hypoxia) or carbon dioxide stimulation]. Consideration is also given to the effect of training on non-respiratory (e.g., locomotor) networks. This review highlights advances in this area of pre-clinical and translational research, with insight into future directions for enhancing plasticity and improving functional outcomes after SCI. |
| first_indexed | 2024-12-21T15:18:14Z |
| format | Article |
| id | doaj.art-f3fdfb9ce1c545d3a5d27663824ccccd |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-12-21T15:18:14Z |
| publishDate | 2021-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-f3fdfb9ce1c545d3a5d27663824ccccd2022-12-21T18:59:06ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022021-09-011510.3389/fncel.2021.700821700821Respiratory Training and Plasticity After Cervical Spinal Cord InjuryMargo Randelman0Margo Randelman1Lyandysha V. Zholudeva2Lyandysha V. Zholudeva3Lyandysha V. Zholudeva4Stéphane Vinit5Michael A. Lane6Michael A. Lane7Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA, United StatesMarion Murray Spinal Cord Research Center, Drexel University College of Medicine, Philadelphia, PA, United StatesDepartment of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA, United StatesMarion Murray Spinal Cord Research Center, Drexel University College of Medicine, Philadelphia, PA, United StatesGladstone Institutes, San Francisco, CA, United StatesINSERM, END-ICAP, Université Paris-Saclay, UVSQ, Versailles, FranceDepartment of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA, United StatesMarion Murray Spinal Cord Research Center, Drexel University College of Medicine, Philadelphia, PA, United StatesWhile spinal cord injuries (SCIs) result in a vast array of functional deficits, many of which are life threatening, the majority of SCIs are anatomically incomplete. Spared neural pathways contribute to functional and anatomical neuroplasticity that can occur spontaneously, or can be harnessed using rehabilitative, electrophysiological, or pharmacological strategies. With a focus on respiratory networks that are affected by cervical level SCI, the present review summarizes how non-invasive respiratory treatments can be used to harness this neuroplastic potential and enhance long-term recovery. Specific attention is given to “respiratory training” strategies currently used clinically (e.g., strength training) and those being developed through pre-clinical and early clinical testing [e.g., intermittent chemical stimulation via altering inhaled oxygen (hypoxia) or carbon dioxide stimulation]. Consideration is also given to the effect of training on non-respiratory (e.g., locomotor) networks. This review highlights advances in this area of pre-clinical and translational research, with insight into future directions for enhancing plasticity and improving functional outcomes after SCI.https://www.frontiersin.org/articles/10.3389/fncel.2021.700821/fullrehabilitationspinal cord injuryneuroplasticityrespirationdiaphragmphrenic |
| spellingShingle | Margo Randelman Margo Randelman Lyandysha V. Zholudeva Lyandysha V. Zholudeva Lyandysha V. Zholudeva Stéphane Vinit Michael A. Lane Michael A. Lane Respiratory Training and Plasticity After Cervical Spinal Cord Injury Frontiers in Cellular Neuroscience rehabilitation spinal cord injury neuroplasticity respiration diaphragm phrenic |
| title | Respiratory Training and Plasticity After Cervical Spinal Cord Injury |
| title_full | Respiratory Training and Plasticity After Cervical Spinal Cord Injury |
| title_fullStr | Respiratory Training and Plasticity After Cervical Spinal Cord Injury |
| title_full_unstemmed | Respiratory Training and Plasticity After Cervical Spinal Cord Injury |
| title_short | Respiratory Training and Plasticity After Cervical Spinal Cord Injury |
| title_sort | respiratory training and plasticity after cervical spinal cord injury |
| topic | rehabilitation spinal cord injury neuroplasticity respiration diaphragm phrenic |
| url | https://www.frontiersin.org/articles/10.3389/fncel.2021.700821/full |
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