Fungal-mediated lung allergic airway disease: The critical role of macrophages and dendritic cells.
Fungi are abundant in the environment, causing our lungs to be constantly exposed to a diverse range of species. While the majority of these are cleared effectively in healthy individuals, constant exposure to spores (especially Aspergillus spp.) can lead to the development of allergic inflammation...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2022-07-01
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| Series: | PLoS Pathogens |
| Online Access: | https://doi.org/10.1371/journal.ppat.1010608 |
| _version_ | 1818192714281254912 |
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| author | Julio Furlong-Silva Peter Charles Cook |
| author_facet | Julio Furlong-Silva Peter Charles Cook |
| author_sort | Julio Furlong-Silva |
| collection | DOAJ |
| description | Fungi are abundant in the environment, causing our lungs to be constantly exposed to a diverse range of species. While the majority of these are cleared effectively in healthy individuals, constant exposure to spores (especially Aspergillus spp.) can lead to the development of allergic inflammation that underpins and worsen diseases such as asthma. Despite this, the precise mechanisms that underpin the development of fungal allergic disease are poorly understood. Innate immune cells, such as macrophages (MΦs) and dendritic cells (DCs), have been shown to be critical for mediating allergic inflammation to a range of different allergens. This review will focus on the crucial role of MΦ and DCs in mediating antifungal immunity, evaluating how these immune cells mediate allergic inflammation within the context of the lung environment. Ultimately, we aim to highlight important future research questions that will lead to novel therapeutic strategies for fungal allergic diseases. |
| first_indexed | 2024-12-12T00:34:53Z |
| format | Article |
| id | doaj.art-f4005f12e8e848b6b1969d77a62e9e51 |
| institution | Directory Open Access Journal |
| issn | 1553-7366 1553-7374 |
| language | English |
| last_indexed | 2024-12-12T00:34:53Z |
| publishDate | 2022-07-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Pathogens |
| spelling | doaj.art-f4005f12e8e848b6b1969d77a62e9e512022-12-22T00:44:24ZengPublic Library of Science (PLoS)PLoS Pathogens1553-73661553-73742022-07-01187e101060810.1371/journal.ppat.1010608Fungal-mediated lung allergic airway disease: The critical role of macrophages and dendritic cells.Julio Furlong-SilvaPeter Charles CookFungi are abundant in the environment, causing our lungs to be constantly exposed to a diverse range of species. While the majority of these are cleared effectively in healthy individuals, constant exposure to spores (especially Aspergillus spp.) can lead to the development of allergic inflammation that underpins and worsen diseases such as asthma. Despite this, the precise mechanisms that underpin the development of fungal allergic disease are poorly understood. Innate immune cells, such as macrophages (MΦs) and dendritic cells (DCs), have been shown to be critical for mediating allergic inflammation to a range of different allergens. This review will focus on the crucial role of MΦ and DCs in mediating antifungal immunity, evaluating how these immune cells mediate allergic inflammation within the context of the lung environment. Ultimately, we aim to highlight important future research questions that will lead to novel therapeutic strategies for fungal allergic diseases.https://doi.org/10.1371/journal.ppat.1010608 |
| spellingShingle | Julio Furlong-Silva Peter Charles Cook Fungal-mediated lung allergic airway disease: The critical role of macrophages and dendritic cells. PLoS Pathogens |
| title | Fungal-mediated lung allergic airway disease: The critical role of macrophages and dendritic cells. |
| title_full | Fungal-mediated lung allergic airway disease: The critical role of macrophages and dendritic cells. |
| title_fullStr | Fungal-mediated lung allergic airway disease: The critical role of macrophages and dendritic cells. |
| title_full_unstemmed | Fungal-mediated lung allergic airway disease: The critical role of macrophages and dendritic cells. |
| title_short | Fungal-mediated lung allergic airway disease: The critical role of macrophages and dendritic cells. |
| title_sort | fungal mediated lung allergic airway disease the critical role of macrophages and dendritic cells |
| url | https://doi.org/10.1371/journal.ppat.1010608 |
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