Antimicrobial peptides modulate lung injury by altering the intestinal microbiota

Antimicrobial peptides modulate lung injury by altering the intestinal microbiota

Abstract Background Mammalian mucosal barriers secrete antimicrobial peptides (AMPs) as critical, host-derived regulators of the microbiota. However, mechanisms that support microbiota homeostasis in response to inflammatory stimuli, such as supraphysiologic oxygen, remain unclear. Results We show t...

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Bibliographic Details
Main Authors: Ahmed Abdelgawad, Teodora Nicola, Isaac Martin, Brian A. Halloran, Kosuke Tanaka, Comfort Y. Adegboye, Pankaj Jain, Changchun Ren, Charitharth V. Lal, Namasivayam Ambalavanan, Amy E. O’Connell, Tamás Jilling, Kent A. Willis
Format: Article
Language:English
Published: BMC 2023-10-01
Series:Microbiome
Subjects:
Microbiome
Gut-lung axis
Chronic lung disease
Lysozyme
Neonatal lung injury
Neonate
Online Access:https://doi.org/10.1186/s40168-023-01673-0

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