The synergistic effect of daidzein and α-tocopherol or ascorbic acid on microsome and LDL oxidation
Isoflavone daidzein brings potential health benefits. Its antioxidant properties are considered to be responsible in part for its protective effects. We investigated the antioxidant effects of daidzein and its interactive effects withα-tocopherol or ascorbic acid on Fe2+/ascorbate-induced oxidation...
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| Format: | Article |
| Language: | English |
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Czech Academy of Agricultural Sciences
2010-10-01
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| Series: | Czech Journal of Food Sciences |
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| Online Access: | https://cjfs.agriculturejournals.cz/artkey/cjf-201005-0005_the-synergistic-effect-of-daidzein-and-945-tocopherol-or-ascorbic-acid-on-microsome-and-ldl-oxidation.php |
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| author | Heya Wang Masibo Wanyonyi Martin Shian Yin |
| author_facet | Heya Wang Masibo Wanyonyi Martin Shian Yin |
| author_sort | Heya Wang |
| collection | DOAJ |
| description | Isoflavone daidzein brings potential health benefits. Its antioxidant properties are considered to be responsible in part for its protective effects. We investigated the antioxidant effects of daidzein and its interactive effects withα-tocopherol or ascorbic acid on Fe2+/ascorbate-induced oxidation of rat liver microsomes and copper-induced human low-density lipoprotein (LDL) oxidation. Although the inhibitory effect of daidzein on lipid peroxidation in microsome was weak, it effectively prevented LDL against oxidative modification by prolonging the lag time, decreasing the propagating rate, and suppressing malonaldehyde (MDA) and carbonyls formation. When daidzein was combined with α-tocopherol in microsomes oxidation and with ascorbic acid in LDL oxidation, the protection was significantly greater than the calculated additive effect of the two individual actions. Thus, daidzein can protect LDL from oxidative modification, and its combination with nutrients may be superior to the action of it alone. These results can help to get a better understanding of the interactions of different antioxidants in vivo. |
| first_indexed | 2024-04-10T08:34:20Z |
| format | Article |
| id | doaj.art-f4030cf8871b420abc56fc20a351e839 |
| institution | Directory Open Access Journal |
| issn | 1212-1800 1805-9317 |
| language | English |
| last_indexed | 2024-04-10T08:34:20Z |
| publishDate | 2010-10-01 |
| publisher | Czech Academy of Agricultural Sciences |
| record_format | Article |
| series | Czech Journal of Food Sciences |
| spelling | doaj.art-f4030cf8871b420abc56fc20a351e8392023-02-23T03:27:45ZengCzech Academy of Agricultural SciencesCzech Journal of Food Sciences1212-18001805-93172010-10-0128538539110.17221/104/2009-CJFScjf-201005-0005The synergistic effect of daidzein and α-tocopherol or ascorbic acid on microsome and LDL oxidationHeya Wang0Masibo Wanyonyi Martin1Shian Yin2National Institute for Nutrition and Food Safety, Chinese Center for Disease Control and Prevention, Beijing, P. R. ChinaSchool of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, P. R. ChinaNational Institute for Nutrition and Food Safety, Chinese Center for Disease Control and Prevention, Beijing, P. R. ChinaIsoflavone daidzein brings potential health benefits. Its antioxidant properties are considered to be responsible in part for its protective effects. We investigated the antioxidant effects of daidzein and its interactive effects withα-tocopherol or ascorbic acid on Fe2+/ascorbate-induced oxidation of rat liver microsomes and copper-induced human low-density lipoprotein (LDL) oxidation. Although the inhibitory effect of daidzein on lipid peroxidation in microsome was weak, it effectively prevented LDL against oxidative modification by prolonging the lag time, decreasing the propagating rate, and suppressing malonaldehyde (MDA) and carbonyls formation. When daidzein was combined with α-tocopherol in microsomes oxidation and with ascorbic acid in LDL oxidation, the protection was significantly greater than the calculated additive effect of the two individual actions. Thus, daidzein can protect LDL from oxidative modification, and its combination with nutrients may be superior to the action of it alone. These results can help to get a better understanding of the interactions of different antioxidants in vivo.https://cjfs.agriculturejournals.cz/artkey/cjf-201005-0005_the-synergistic-effect-of-daidzein-and-945-tocopherol-or-ascorbic-acid-on-microsome-and-ldl-oxidation.phpantioxidant effectssynergismdaidzeinascorbic acidα-tocopherolldlmicrosome |
| spellingShingle | Heya Wang Masibo Wanyonyi Martin Shian Yin The synergistic effect of daidzein and α-tocopherol or ascorbic acid on microsome and LDL oxidation Czech Journal of Food Sciences antioxidant effects synergism daidzein ascorbic acid α -tocopherol ldl microsome |
| title | The synergistic effect of daidzein and α-tocopherol or ascorbic acid on microsome and LDL oxidation |
| title_full | The synergistic effect of daidzein and α-tocopherol or ascorbic acid on microsome and LDL oxidation |
| title_fullStr | The synergistic effect of daidzein and α-tocopherol or ascorbic acid on microsome and LDL oxidation |
| title_full_unstemmed | The synergistic effect of daidzein and α-tocopherol or ascorbic acid on microsome and LDL oxidation |
| title_short | The synergistic effect of daidzein and α-tocopherol or ascorbic acid on microsome and LDL oxidation |
| title_sort | synergistic effect of daidzein and α tocopherol or ascorbic acid on microsome and ldl oxidation |
| topic | antioxidant effects synergism daidzein ascorbic acid α -tocopherol ldl microsome |
| url | https://cjfs.agriculturejournals.cz/artkey/cjf-201005-0005_the-synergistic-effect-of-daidzein-and-945-tocopherol-or-ascorbic-acid-on-microsome-and-ldl-oxidation.php |
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