Exploring Implementation of Personal Breast Cancer Risk Assessments
Personal Breast Cancer (BC) Risk Assessments (PBCRA) have potential to stratify women into clinically-actionable BC risk categories. As this could involve population-wide genomic testing, women’s attitudes to PBCRA and views on acceptable implementation platforms must be considered to ensure optimal...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-09-01
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| Series: | Journal of Personalized Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-4426/11/10/992 |
| _version_ | 1797514211248570368 |
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| author | Maria A. Sierra Jack C. W. Wheeler Lisa Devereux Alison H. Trainer Louise Keogh |
| author_facet | Maria A. Sierra Jack C. W. Wheeler Lisa Devereux Alison H. Trainer Louise Keogh |
| author_sort | Maria A. Sierra |
| collection | DOAJ |
| description | Personal Breast Cancer (BC) Risk Assessments (PBCRA) have potential to stratify women into clinically-actionable BC risk categories. As this could involve population-wide genomic testing, women’s attitudes to PBCRA and views on acceptable implementation platforms must be considered to ensure optimal population participation. We explored these issues with 31 women with different BC risk profiles through semi-structured focus group discussions or interviews. Inductive thematic coding of transcripts was performed. Subsequently, women listed factors that would impact on their decision to participate. Participants’ attitudes to PBCRA were positive. Identified themes included that PBCRA acceptance hinges on result actionability. Women value the ability to inform decision-making. Participants reported anxiety, stress, and genetic discrimination as potential barriers. The age at which PBCRA was offered, ease of access, and how results are returned held importance. Most women value the opportunity for PBCRA to inform increased surveillance, while highlighting hesitance to accept reduced surveillance as they find reassurance in regular screening. Women with <i>BRCA</i> pathogenic variants value the potential for PBCRA to identify a lower cancer risk and potentially inform delayed prophylactic surgery. This study highlights complexities in adopting advances in BC early detection, especially for current users who value existing processes as a social good. |
| first_indexed | 2024-03-10T06:28:25Z |
| format | Article |
| id | doaj.art-f403d4f6d58d4274ad87b5a2144cab75 |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-10T06:28:25Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-f403d4f6d58d4274ad87b5a2144cab752023-11-22T18:48:57ZengMDPI AGJournal of Personalized Medicine2075-44262021-09-01111099210.3390/jpm11100992Exploring Implementation of Personal Breast Cancer Risk AssessmentsMaria A. Sierra0Jack C. W. Wheeler1Lisa Devereux2Alison H. Trainer3Louise Keogh4Miller School of Medicine, University of Miami, Miami, FL 33136, USACentre for Health Equity, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC 3000, AustraliaResearch Division, Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC 3000, AustraliaParkville Familial Cancer Centre, Melbourne, VIC 3000, AustraliaCentre for Health Equity, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC 3000, AustraliaPersonal Breast Cancer (BC) Risk Assessments (PBCRA) have potential to stratify women into clinically-actionable BC risk categories. As this could involve population-wide genomic testing, women’s attitudes to PBCRA and views on acceptable implementation platforms must be considered to ensure optimal population participation. We explored these issues with 31 women with different BC risk profiles through semi-structured focus group discussions or interviews. Inductive thematic coding of transcripts was performed. Subsequently, women listed factors that would impact on their decision to participate. Participants’ attitudes to PBCRA were positive. Identified themes included that PBCRA acceptance hinges on result actionability. Women value the ability to inform decision-making. Participants reported anxiety, stress, and genetic discrimination as potential barriers. The age at which PBCRA was offered, ease of access, and how results are returned held importance. Most women value the opportunity for PBCRA to inform increased surveillance, while highlighting hesitance to accept reduced surveillance as they find reassurance in regular screening. Women with <i>BRCA</i> pathogenic variants value the potential for PBCRA to identify a lower cancer risk and potentially inform delayed prophylactic surgery. This study highlights complexities in adopting advances in BC early detection, especially for current users who value existing processes as a social good.https://www.mdpi.com/2075-4426/11/10/992risk-stratified breast screeningpolygenic riskimplementationbreast cancer risk |
| spellingShingle | Maria A. Sierra Jack C. W. Wheeler Lisa Devereux Alison H. Trainer Louise Keogh Exploring Implementation of Personal Breast Cancer Risk Assessments Journal of Personalized Medicine risk-stratified breast screening polygenic risk implementation breast cancer risk |
| title | Exploring Implementation of Personal Breast Cancer Risk Assessments |
| title_full | Exploring Implementation of Personal Breast Cancer Risk Assessments |
| title_fullStr | Exploring Implementation of Personal Breast Cancer Risk Assessments |
| title_full_unstemmed | Exploring Implementation of Personal Breast Cancer Risk Assessments |
| title_short | Exploring Implementation of Personal Breast Cancer Risk Assessments |
| title_sort | exploring implementation of personal breast cancer risk assessments |
| topic | risk-stratified breast screening polygenic risk implementation breast cancer risk |
| url | https://www.mdpi.com/2075-4426/11/10/992 |
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