Endothelial dysfunction in osteoarthrosis patients: changes in response to teraflex treatment
Aim. To investigate severity of endothelial damage and its function in osteoarthrosis patients, changes in endothelial dysfunction in response to teraflex treatment. Material and methods. Eighty patients with manifest gonarthrosis of stage I-II participated in the trial. They received teraflex for 3...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
"Consilium Medicum" Publishing house
2008-12-01
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| Series: | Терапевтический архив |
| Subjects: | |
| Online Access: | https://ter-arkhiv.ru/0040-3660/article/view/30249 |
| _version_ | 1818258953368240128 |
|---|---|
| author | A P Rebrov I A Kharitonova A P Rebrov I A Kharitonova |
| author_facet | A P Rebrov I A Kharitonova A P Rebrov I A Kharitonova |
| author_sort | A P Rebrov |
| collection | DOAJ |
| description | Aim. To investigate severity of endothelial damage and its function in osteoarthrosis patients, changes in endothelial dysfunction in response to teraflex treatment.
Material and methods. Eighty patients with manifest gonarthrosis of stage I-II participated in the trial. They received teraflex for 3 months. Treatment efficacy was estimated by Leken's index, pain in the joints, need in analgetics, treatment efficacy in the opinion of the doctor and patient. Endothelial function was assessed by changes in antithrombogenic properties of vascular walls (anticoagulatory and fibrinolytic activity of the vascular wall), in activity of Willebrand factor, circulating endothelial cells. Examination was made before the treatment, after 1 and 3 months of therapy.
Results. A positive effect of teraflex manifested with a significant regress of the Lekken's index, pain syndrome, need in nonsteroidal anti-inflammatory drugs, relief of endothelial damage, improvement of antithrombogenic activity of vascular wall.
Conclusion. Teraflex has a manifest symptom-modifying effect, good tolerance, reduces endothelial damage. |
| first_indexed | 2024-12-12T18:07:44Z |
| format | Article |
| id | doaj.art-f40434315bbe4a10bc420eda2745ac47 |
| institution | Directory Open Access Journal |
| issn | 0040-3660 2309-5342 |
| language | Russian |
| last_indexed | 2024-12-12T18:07:44Z |
| publishDate | 2008-12-01 |
| publisher | "Consilium Medicum" Publishing house |
| record_format | Article |
| series | Терапевтический архив |
| spelling | doaj.art-f40434315bbe4a10bc420eda2745ac472022-12-22T00:16:27Zrus"Consilium Medicum" Publishing houseТерапевтический архив0040-36602309-53422008-12-018012323727276Endothelial dysfunction in osteoarthrosis patients: changes in response to teraflex treatmentA P RebrovI A KharitonovaA P RebrovI A KharitonovaAim. To investigate severity of endothelial damage and its function in osteoarthrosis patients, changes in endothelial dysfunction in response to teraflex treatment. Material and methods. Eighty patients with manifest gonarthrosis of stage I-II participated in the trial. They received teraflex for 3 months. Treatment efficacy was estimated by Leken's index, pain in the joints, need in analgetics, treatment efficacy in the opinion of the doctor and patient. Endothelial function was assessed by changes in antithrombogenic properties of vascular walls (anticoagulatory and fibrinolytic activity of the vascular wall), in activity of Willebrand factor, circulating endothelial cells. Examination was made before the treatment, after 1 and 3 months of therapy. Results. A positive effect of teraflex manifested with a significant regress of the Lekken's index, pain syndrome, need in nonsteroidal anti-inflammatory drugs, relief of endothelial damage, improvement of antithrombogenic activity of vascular wall. Conclusion. Teraflex has a manifest symptom-modifying effect, good tolerance, reduces endothelial damage.https://ter-arkhiv.ru/0040-3660/article/view/30249osteoarthrosisendothelial dysfunctionteraflex |
| spellingShingle | A P Rebrov I A Kharitonova A P Rebrov I A Kharitonova Endothelial dysfunction in osteoarthrosis patients: changes in response to teraflex treatment Терапевтический архив osteoarthrosis endothelial dysfunction teraflex |
| title | Endothelial dysfunction in osteoarthrosis patients: changes in response to teraflex treatment |
| title_full | Endothelial dysfunction in osteoarthrosis patients: changes in response to teraflex treatment |
| title_fullStr | Endothelial dysfunction in osteoarthrosis patients: changes in response to teraflex treatment |
| title_full_unstemmed | Endothelial dysfunction in osteoarthrosis patients: changes in response to teraflex treatment |
| title_short | Endothelial dysfunction in osteoarthrosis patients: changes in response to teraflex treatment |
| title_sort | endothelial dysfunction in osteoarthrosis patients changes in response to teraflex treatment |
| topic | osteoarthrosis endothelial dysfunction teraflex |
| url | https://ter-arkhiv.ru/0040-3660/article/view/30249 |
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