Blood biomarker changes following therapeutic hypothermia in ischemic stroke
Abstract Introduction Therapeutic hypothermia is a promising candidate for stroke treatment although its efficacy has not yet been demonstrated in patients. Changes in blood molecules could act as surrogate markers to evaluate the efficacy and safety of therapeutic cooling. Methods Blood samples fro...
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| Format: | Article |
| Language: | English |
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Wiley
2023-11-01
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| Series: | Brain and Behavior |
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| Online Access: | https://doi.org/10.1002/brb3.3230 |
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| author | Elena Palà Anna Penalba Alejandro Bustamante Teresa García‐Berrocoso Marcel Lamana‐Vallverdú Christian Meisel Andreas Meisel H. Bart van der Worp Malcolm R Macleod Bernd Kallmünzer Stefan Schwab Joan Montaner |
| author_facet | Elena Palà Anna Penalba Alejandro Bustamante Teresa García‐Berrocoso Marcel Lamana‐Vallverdú Christian Meisel Andreas Meisel H. Bart van der Worp Malcolm R Macleod Bernd Kallmünzer Stefan Schwab Joan Montaner |
| author_sort | Elena Palà |
| collection | DOAJ |
| description | Abstract Introduction Therapeutic hypothermia is a promising candidate for stroke treatment although its efficacy has not yet been demonstrated in patients. Changes in blood molecules could act as surrogate markers to evaluate the efficacy and safety of therapeutic cooling. Methods Blood samples from 54 patients included in the EuroHYP‐1 study (27 treated with hypothermia, and 27 controls) were obtained at baseline, 24 ± 2 h, and 72 ± 4 h. The levels of a panel of 27 biomarkers, including matrix metalloproteinases and cardiac and inflammatory markers, were measured. Results Metalloproteinase‐3 (MMP‐3), fatty‐acid‐binding protein (FABP), and interleukin‐8 (IL‐8) increased over time in relation to the hypothermia treatment. Statistically significant correlations between the minimum temperature achieved by each patient in the hypothermia group and the MMP‐3 level measured at 72 h, FABP level measured at 24 h, and IL‐8 levels measured at 24 and 72 h were found. No differential biomarker levels were observed in patients with poor or favorable outcomes according to modified Rankin Scale scores. Conclusion Although the exact roles of MMP3, FABP, and IL‐8 in hypothermia‐treated stroke patients are not known, further exploration is needed to confirm their roles in brain ischemia. |
| first_indexed | 2024-03-11T11:40:06Z |
| format | Article |
| id | doaj.art-f404e9dfee99478b8c046572f0dc8447 |
| institution | Directory Open Access Journal |
| issn | 2162-3279 |
| language | English |
| last_indexed | 2024-03-11T11:40:06Z |
| publishDate | 2023-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Brain and Behavior |
| spelling | doaj.art-f404e9dfee99478b8c046572f0dc84472023-11-10T06:53:59ZengWileyBrain and Behavior2162-32792023-11-011311n/an/a10.1002/brb3.3230Blood biomarker changes following therapeutic hypothermia in ischemic strokeElena Palà0Anna Penalba1Alejandro Bustamante2Teresa García‐Berrocoso3Marcel Lamana‐Vallverdú4Christian Meisel5Andreas Meisel6H. Bart van der Worp7Malcolm R Macleod8Bernd Kallmünzer9Stefan Schwab10Joan Montaner11Neurovascular Research Laboratory Vall d'Hebron Institute of Research (VHIR)–Universitat Autónoma de Barcelona Barcelona SpainNeurovascular Research Laboratory Vall d'Hebron Institute of Research (VHIR)–Universitat Autónoma de Barcelona Barcelona SpainNeurovascular Research Laboratory Vall d'Hebron Institute of Research (VHIR)–Universitat Autónoma de Barcelona Barcelona SpainNeurovascular Research Laboratory Vall d'Hebron Institute of Research (VHIR)–Universitat Autónoma de Barcelona Barcelona SpainNeurovascular Research Laboratory Vall d'Hebron Institute of Research (VHIR)–Universitat Autónoma de Barcelona Barcelona SpainInstitute for Medical Immunology Charité–Universitätsmedizin Berlin Berlin GermanyDepartment of Neurology and Center for Stroke Research Berlin Charité University Hospital Berlin Berlin GermanyDepartment of Neurology and Neurosurgery Brain Center University Medical Center Utrecht Utrecht The NetherlandsCentre for Clinical Brain Sciences University of Edinburgh Edinburgh Scotland UKDepartment of Neurology Universitätsklinikum Erlangen Erlangen GermanyDepartment of Neurology Universitätsklinikum Erlangen Erlangen GermanyNeurovascular Research Laboratory Vall d'Hebron Institute of Research (VHIR)–Universitat Autónoma de Barcelona Barcelona SpainAbstract Introduction Therapeutic hypothermia is a promising candidate for stroke treatment although its efficacy has not yet been demonstrated in patients. Changes in blood molecules could act as surrogate markers to evaluate the efficacy and safety of therapeutic cooling. Methods Blood samples from 54 patients included in the EuroHYP‐1 study (27 treated with hypothermia, and 27 controls) were obtained at baseline, 24 ± 2 h, and 72 ± 4 h. The levels of a panel of 27 biomarkers, including matrix metalloproteinases and cardiac and inflammatory markers, were measured. Results Metalloproteinase‐3 (MMP‐3), fatty‐acid‐binding protein (FABP), and interleukin‐8 (IL‐8) increased over time in relation to the hypothermia treatment. Statistically significant correlations between the minimum temperature achieved by each patient in the hypothermia group and the MMP‐3 level measured at 72 h, FABP level measured at 24 h, and IL‐8 levels measured at 24 and 72 h were found. No differential biomarker levels were observed in patients with poor or favorable outcomes according to modified Rankin Scale scores. Conclusion Although the exact roles of MMP3, FABP, and IL‐8 in hypothermia‐treated stroke patients are not known, further exploration is needed to confirm their roles in brain ischemia.https://doi.org/10.1002/brb3.3230biomarkershypothermiaischemiastroke |
| spellingShingle | Elena Palà Anna Penalba Alejandro Bustamante Teresa García‐Berrocoso Marcel Lamana‐Vallverdú Christian Meisel Andreas Meisel H. Bart van der Worp Malcolm R Macleod Bernd Kallmünzer Stefan Schwab Joan Montaner Blood biomarker changes following therapeutic hypothermia in ischemic stroke Brain and Behavior biomarkers hypothermia ischemia stroke |
| title | Blood biomarker changes following therapeutic hypothermia in ischemic stroke |
| title_full | Blood biomarker changes following therapeutic hypothermia in ischemic stroke |
| title_fullStr | Blood biomarker changes following therapeutic hypothermia in ischemic stroke |
| title_full_unstemmed | Blood biomarker changes following therapeutic hypothermia in ischemic stroke |
| title_short | Blood biomarker changes following therapeutic hypothermia in ischemic stroke |
| title_sort | blood biomarker changes following therapeutic hypothermia in ischemic stroke |
| topic | biomarkers hypothermia ischemia stroke |
| url | https://doi.org/10.1002/brb3.3230 |
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