Predictive factors of early graft loss in living donor liver transplantation
CONTEXT: Living donor liver transplantation has become an alternative to reduce the lack of organ donation. OBJECTIVE: To identify factors predictive of early graft loss in the first 3 months after living donor liver transplantation. METHODS: Seventy-eight adults submitted to living donor liver tran...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia (IBEPEGE)
2012-06-01
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| Series: | Arquivos de Gastroenterologia |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-28032012000200011&lng=en&tlng=en |
| _version_ | 1818112167104217088 |
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| author | Rogério Camargo Pinheiro Alves Eduardo Antunes da Fonseca Carla Adriana Loureiro de Mattos Sofia Abdalla José Eduardo Gonçalves Jaques Waisberg |
| author_facet | Rogério Camargo Pinheiro Alves Eduardo Antunes da Fonseca Carla Adriana Loureiro de Mattos Sofia Abdalla José Eduardo Gonçalves Jaques Waisberg |
| author_sort | Rogério Camargo Pinheiro Alves |
| collection | DOAJ |
| description | CONTEXT: Living donor liver transplantation has become an alternative to reduce the lack of organ donation. OBJECTIVE: To identify factors predictive of early graft loss in the first 3 months after living donor liver transplantation. METHODS: Seventy-eight adults submitted to living donor liver transplantation were divided into group I with 62 (79.5%) patients with graft survival longer than 3 months, and group II with 16 (20.5%) patients who died and/or showed graft failure within 3 months after liver transplantation. The variables analyzed were gender, age, etiology of liver disease, Child-Pugh classification, model of end-stage liver disease (MELD score), pretransplantation serum sodium level, and graft weight-to-recipient body weight (GRBW) ratio. The GRBW ratio was categorized into < 0.8 and MELD score into >18. The chi-square test, Student t-test and uni- and multivariate analysis were used for the evaluation of risk factors for early graft loss. RESULTS: MELD score <18 (P<0.001) and serum sodium level > 135 mEq/L (P = 0.03) were higher in group II than in group I. In the multivariate analysis MELD scores > 18 (P<0.001) and GRBW ratios < 0.8 (P<0.04) were significant. CONCLUSIONS: MELD scores >18 and GRBW < 0.8 ratios are associated with higher probability of graft failure after living donor liver transplantation. |
| first_indexed | 2024-12-11T03:14:38Z |
| format | Article |
| id | doaj.art-f406b14531e3453e8a7c8ff55f0eb17d |
| institution | Directory Open Access Journal |
| issn | 1678-4219 |
| language | English |
| last_indexed | 2024-12-11T03:14:38Z |
| publishDate | 2012-06-01 |
| publisher | Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia (IBEPEGE) |
| record_format | Article |
| series | Arquivos de Gastroenterologia |
| spelling | doaj.art-f406b14531e3453e8a7c8ff55f0eb17d2022-12-22T01:22:48ZengInstituto Brasileiro de Estudos e Pesquisas de Gastroenterologia (IBEPEGE)Arquivos de Gastroenterologia1678-42192012-06-0149215716110.1590/S0004-28032012000200011S0004-28032012000200011Predictive factors of early graft loss in living donor liver transplantationRogério Camargo Pinheiro Alves0Eduardo Antunes da Fonseca1Carla Adriana Loureiro de Mattos2Sofia Abdalla3José Eduardo Gonçalves4Jaques Waisberg5Hospital do Servidor Público Estadual Francisco Morato de OliveiraHospital A. C. CamargoHospital Sírio-LibanêsDepartment of SurgeryDepartment of SurgeryDepartment of SurgeryCONTEXT: Living donor liver transplantation has become an alternative to reduce the lack of organ donation. OBJECTIVE: To identify factors predictive of early graft loss in the first 3 months after living donor liver transplantation. METHODS: Seventy-eight adults submitted to living donor liver transplantation were divided into group I with 62 (79.5%) patients with graft survival longer than 3 months, and group II with 16 (20.5%) patients who died and/or showed graft failure within 3 months after liver transplantation. The variables analyzed were gender, age, etiology of liver disease, Child-Pugh classification, model of end-stage liver disease (MELD score), pretransplantation serum sodium level, and graft weight-to-recipient body weight (GRBW) ratio. The GRBW ratio was categorized into < 0.8 and MELD score into >18. The chi-square test, Student t-test and uni- and multivariate analysis were used for the evaluation of risk factors for early graft loss. RESULTS: MELD score <18 (P<0.001) and serum sodium level > 135 mEq/L (P = 0.03) were higher in group II than in group I. In the multivariate analysis MELD scores > 18 (P<0.001) and GRBW ratios < 0.8 (P<0.04) were significant. CONCLUSIONS: MELD scores >18 and GRBW < 0.8 ratios are associated with higher probability of graft failure after living donor liver transplantation.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-28032012000200011&lng=en&tlng=enTransplante de fígadoDoadores vivosPrognósticoDisfunção primária do enxertoSobrevivência do enxerto |
| spellingShingle | Rogério Camargo Pinheiro Alves Eduardo Antunes da Fonseca Carla Adriana Loureiro de Mattos Sofia Abdalla José Eduardo Gonçalves Jaques Waisberg Predictive factors of early graft loss in living donor liver transplantation Arquivos de Gastroenterologia Transplante de fígado Doadores vivos Prognóstico Disfunção primária do enxerto Sobrevivência do enxerto |
| title | Predictive factors of early graft loss in living donor liver transplantation |
| title_full | Predictive factors of early graft loss in living donor liver transplantation |
| title_fullStr | Predictive factors of early graft loss in living donor liver transplantation |
| title_full_unstemmed | Predictive factors of early graft loss in living donor liver transplantation |
| title_short | Predictive factors of early graft loss in living donor liver transplantation |
| title_sort | predictive factors of early graft loss in living donor liver transplantation |
| topic | Transplante de fígado Doadores vivos Prognóstico Disfunção primária do enxerto Sobrevivência do enxerto |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-28032012000200011&lng=en&tlng=en |
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