Clinical characteristics and risk factors of polymicrobial Staphylococcus aureus bloodstream infections
Abstract Background Although Staphylococcus aureus bloodstream infections (SA-BSI) are a common and important infection, polymicrobial SA-BSI are infrequently reported. The aim of this study was to investigate the clinical characteristics and risk factors of polymicrobial SA-BSI in comparison with m...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-05-01
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| Series: | Antimicrobial Resistance and Infection Control |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13756-020-00741-6 |
| _version_ | 1818519022685126656 |
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| author | Cheng Zheng Shufang Zhang Qingqing Chen Li Zhong Tiancha Huang Xijiang Zhang Kai Zhang Hongwei Zhou Jiachang Cai Linlin Du Changming Wang Wei Cui Gensheng Zhang |
| author_facet | Cheng Zheng Shufang Zhang Qingqing Chen Li Zhong Tiancha Huang Xijiang Zhang Kai Zhang Hongwei Zhou Jiachang Cai Linlin Du Changming Wang Wei Cui Gensheng Zhang |
| author_sort | Cheng Zheng |
| collection | DOAJ |
| description | Abstract Background Although Staphylococcus aureus bloodstream infections (SA-BSI) are a common and important infection, polymicrobial SA-BSI are infrequently reported. The aim of this study was to investigate the clinical characteristics and risk factors of polymicrobial SA-BSI in comparison with monomicrobial SA-BSI. Methods A single-center retrospective observational study was performed between Jan 1, 2013, and Dec 31, 2018 at a tertiary hospital. All patients with SA-BSI were enrolled, and their clinical data were gathered by reviewing electronic medical records. Results A total of 349 patients with SA-BSI were enrolled including 54 cases (15.5%) with polymicrobial SA-BSI. In multivariable analysis, burn injury (adjusted odds ratio [OR], 7.04; 95% confidence interval [CI], 1.71–28.94), need of blood transfusion (aOR, 2.72; 95% CI, 1.14–6.50), use of mechanical ventilation (aOR, 3.11; 95% CI, 1.16–8.30), the length of prior hospital stay (aOR, 1.02; 95% CI, 1.00–1.03), and pneumonia as primary site of infection (aOR, 4.22; 95% CI, 1.69–10.51) were independent factors of polymicrobial SA-BSI. In comparison with monomicrobial SA-BSI, patients with polymicrobial SA-BSI had longer length of ICU stay [median days, 23(6.25,49.25) vs. 0(0,12), p < 0.01] and hospital stay [median days, 50(21.75,85.75) vs. 28(15,49), p < 0.01], and showed a higher 28-day mortality (29.6% vs. 15.3%, p = 0.01). Conclusions Burn injury, blood transfusion, mechanical ventilation, the length of prior hospital stay, and pneumonia as a primary site of infection are independent risk factors for polymicrobial SA-BSI. In addition, patients with polymicrobial SA-BSI might have worse outcomes compared with monomicrobial SA-BSI. |
| first_indexed | 2024-12-11T01:18:08Z |
| format | Article |
| id | doaj.art-f406c56d38e94a73a3bb8541de625ca6 |
| institution | Directory Open Access Journal |
| issn | 2047-2994 |
| language | English |
| last_indexed | 2024-12-11T01:18:08Z |
| publishDate | 2020-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Antimicrobial Resistance and Infection Control |
| spelling | doaj.art-f406c56d38e94a73a3bb8541de625ca62022-12-22T01:25:48ZengBMCAntimicrobial Resistance and Infection Control2047-29942020-05-019111110.1186/s13756-020-00741-6Clinical characteristics and risk factors of polymicrobial Staphylococcus aureus bloodstream infectionsCheng Zheng0Shufang Zhang1Qingqing Chen2Li Zhong3Tiancha Huang4Xijiang Zhang5Kai Zhang6Hongwei Zhou7Jiachang Cai8Linlin Du9Changming Wang10Wei Cui11Gensheng Zhang12Department of Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of MedicineDepartment of Cardiology, Second Affiliated Hospital, Zhejiang University School of MedicineDepartment of Critical Care Medicine, Taizhou Enze Medical Center (Group) Enze HospitalDepartment of Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of MedicineDepartment of Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of MedicineDepartment of Critical Care Medicine, Taizhou Municipal HospitalDepartment of Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of MedicineClinical Microbiology Laboratory, Second Affiliated Hospital, Zhejiang University School of MedicineClinical Microbiology Laboratory, Second Affiliated Hospital, Zhejiang University School of MedicineDepartment of Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of MedicineDepartment of Critical Care Medicine, Taizhou Municipal HospitalDepartment of Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of MedicineDepartment of Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of MedicineAbstract Background Although Staphylococcus aureus bloodstream infections (SA-BSI) are a common and important infection, polymicrobial SA-BSI are infrequently reported. The aim of this study was to investigate the clinical characteristics and risk factors of polymicrobial SA-BSI in comparison with monomicrobial SA-BSI. Methods A single-center retrospective observational study was performed between Jan 1, 2013, and Dec 31, 2018 at a tertiary hospital. All patients with SA-BSI were enrolled, and their clinical data were gathered by reviewing electronic medical records. Results A total of 349 patients with SA-BSI were enrolled including 54 cases (15.5%) with polymicrobial SA-BSI. In multivariable analysis, burn injury (adjusted odds ratio [OR], 7.04; 95% confidence interval [CI], 1.71–28.94), need of blood transfusion (aOR, 2.72; 95% CI, 1.14–6.50), use of mechanical ventilation (aOR, 3.11; 95% CI, 1.16–8.30), the length of prior hospital stay (aOR, 1.02; 95% CI, 1.00–1.03), and pneumonia as primary site of infection (aOR, 4.22; 95% CI, 1.69–10.51) were independent factors of polymicrobial SA-BSI. In comparison with monomicrobial SA-BSI, patients with polymicrobial SA-BSI had longer length of ICU stay [median days, 23(6.25,49.25) vs. 0(0,12), p < 0.01] and hospital stay [median days, 50(21.75,85.75) vs. 28(15,49), p < 0.01], and showed a higher 28-day mortality (29.6% vs. 15.3%, p = 0.01). Conclusions Burn injury, blood transfusion, mechanical ventilation, the length of prior hospital stay, and pneumonia as a primary site of infection are independent risk factors for polymicrobial SA-BSI. In addition, patients with polymicrobial SA-BSI might have worse outcomes compared with monomicrobial SA-BSI.http://link.springer.com/article/10.1186/s13756-020-00741-6Staphylococcus aureusBacteremiaPolymicrobial Staphylococcus aureus bloodstream infectionsRisk factorsMortality |
| spellingShingle | Cheng Zheng Shufang Zhang Qingqing Chen Li Zhong Tiancha Huang Xijiang Zhang Kai Zhang Hongwei Zhou Jiachang Cai Linlin Du Changming Wang Wei Cui Gensheng Zhang Clinical characteristics and risk factors of polymicrobial Staphylococcus aureus bloodstream infections Antimicrobial Resistance and Infection Control Staphylococcus aureus Bacteremia Polymicrobial Staphylococcus aureus bloodstream infections Risk factors Mortality |
| title | Clinical characteristics and risk factors of polymicrobial Staphylococcus aureus bloodstream infections |
| title_full | Clinical characteristics and risk factors of polymicrobial Staphylococcus aureus bloodstream infections |
| title_fullStr | Clinical characteristics and risk factors of polymicrobial Staphylococcus aureus bloodstream infections |
| title_full_unstemmed | Clinical characteristics and risk factors of polymicrobial Staphylococcus aureus bloodstream infections |
| title_short | Clinical characteristics and risk factors of polymicrobial Staphylococcus aureus bloodstream infections |
| title_sort | clinical characteristics and risk factors of polymicrobial staphylococcus aureus bloodstream infections |
| topic | Staphylococcus aureus Bacteremia Polymicrobial Staphylococcus aureus bloodstream infections Risk factors Mortality |
| url | http://link.springer.com/article/10.1186/s13756-020-00741-6 |
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