Anti-Inflammatory Effects of a <i>Cordyceps sinensis</i> Mycelium Culture Extract (Cs-4) on Rodent Models of Allergic Rhinitis and Asthma
Allergic rhinitis and asthma are common chronic allergic diseases of the respiratory tract, which are accompanied by immunoglobulin E (IgE)-mediated inflammation and the involvement of type 2 T helper cells, mast cells, and eosinophils. <i>Cordyceps sinensis</i> (Berk.) Sacc is a fungal...
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MDPI AG
2020-09-01
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| Series: | Molecules |
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| author | Jihang Chen Wing Man Chan Hoi Yan Leung Pou Kuan Leong Choly Tat Ming Yan Kam Ming Ko |
| author_facet | Jihang Chen Wing Man Chan Hoi Yan Leung Pou Kuan Leong Choly Tat Ming Yan Kam Ming Ko |
| author_sort | Jihang Chen |
| collection | DOAJ |
| description | Allergic rhinitis and asthma are common chronic allergic diseases of the respiratory tract, which are accompanied by immunoglobulin E (IgE)-mediated inflammation and the involvement of type 2 T helper cells, mast cells, and eosinophils. <i>Cordyceps sinensis</i> (Berk.) Sacc is a fungal parasite on the larva of Lepidoptera. It has been considered to be a health-promoting food and, also, one of the best-known herbal remedies for the treatment of airway diseases, such as asthma and lung inflammation. In the present study, we demonstrated the antiallergic rhinitis effect of Cs-4, a water extract prepared from the mycelium culture of <i>Cordyceps sinensis</i> (Berk) Sacc, on ovalbumin (OVA)-induced allergic rhinitis in mice and the anti-asthmatic effect of Cs-4 in a rat model of asthma. Treatment with Cs-4 suppressed the nasal symptoms induced in OVA-sensitized and challenged mice. The inhibition was associated with a reduction in IgE/OVA-IgE and interleukin (IL)-4/IL-13 levels in the nasal fluid. Cs-4 treatment also decreased airway responsiveness and ameliorated the scratching behavior in capsaicin-challenged rats. It also reduced plasma IgE levels, as well as IgE and eosinophil peroxidase levels, in the bronchoalveolar fluid. Cs-4 treatment completely suppressed the increases in IL-4, IL-5, and IL-13 levels in rat lung tissue. In conclusion, our results suggest that Cs-4 has the potential to alleviate immune hypersensitivity reactions in allergic rhinitis and asthma. |
| first_indexed | 2024-03-10T16:34:26Z |
| format | Article |
| id | doaj.art-f40771b8115243ee9ba31e7515aca855 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T16:34:26Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-f40771b8115243ee9ba31e7515aca8552023-11-20T12:37:49ZengMDPI AGMolecules1420-30492020-09-012518405110.3390/molecules25184051Anti-Inflammatory Effects of a <i>Cordyceps sinensis</i> Mycelium Culture Extract (Cs-4) on Rodent Models of Allergic Rhinitis and AsthmaJihang Chen0Wing Man Chan1Hoi Yan Leung2Pou Kuan Leong3Choly Tat Ming Yan4Kam Ming Ko5School of Life and Health Science, The Chinese University of Hong Kong, Shenzhen 518172, ChinaDivision of Life Science, The Hong Kong University of Science & Technology, Clear Water Bay, Hong Kong SAR 999077, ChinaDivision of Life Science, The Hong Kong University of Science & Technology, Clear Water Bay, Hong Kong SAR 999077, ChinaDivision of Life Science, The Hong Kong University of Science & Technology, Clear Water Bay, Hong Kong SAR 999077, ChinaRoyal Medic Group Holding Limited, 313 Castle Peak Road, Hong Kong SAR 999077, ChinaDivision of Life Science, The Hong Kong University of Science & Technology, Clear Water Bay, Hong Kong SAR 999077, ChinaAllergic rhinitis and asthma are common chronic allergic diseases of the respiratory tract, which are accompanied by immunoglobulin E (IgE)-mediated inflammation and the involvement of type 2 T helper cells, mast cells, and eosinophils. <i>Cordyceps sinensis</i> (Berk.) Sacc is a fungal parasite on the larva of Lepidoptera. It has been considered to be a health-promoting food and, also, one of the best-known herbal remedies for the treatment of airway diseases, such as asthma and lung inflammation. In the present study, we demonstrated the antiallergic rhinitis effect of Cs-4, a water extract prepared from the mycelium culture of <i>Cordyceps sinensis</i> (Berk) Sacc, on ovalbumin (OVA)-induced allergic rhinitis in mice and the anti-asthmatic effect of Cs-4 in a rat model of asthma. Treatment with Cs-4 suppressed the nasal symptoms induced in OVA-sensitized and challenged mice. The inhibition was associated with a reduction in IgE/OVA-IgE and interleukin (IL)-4/IL-13 levels in the nasal fluid. Cs-4 treatment also decreased airway responsiveness and ameliorated the scratching behavior in capsaicin-challenged rats. It also reduced plasma IgE levels, as well as IgE and eosinophil peroxidase levels, in the bronchoalveolar fluid. Cs-4 treatment completely suppressed the increases in IL-4, IL-5, and IL-13 levels in rat lung tissue. In conclusion, our results suggest that Cs-4 has the potential to alleviate immune hypersensitivity reactions in allergic rhinitis and asthma.https://www.mdpi.com/1420-3049/25/18/4051Cordycepsanti-inflammatory effectallergic rhinitisasthma |
| spellingShingle | Jihang Chen Wing Man Chan Hoi Yan Leung Pou Kuan Leong Choly Tat Ming Yan Kam Ming Ko Anti-Inflammatory Effects of a <i>Cordyceps sinensis</i> Mycelium Culture Extract (Cs-4) on Rodent Models of Allergic Rhinitis and Asthma Molecules Cordyceps anti-inflammatory effect allergic rhinitis asthma |
| title | Anti-Inflammatory Effects of a <i>Cordyceps sinensis</i> Mycelium Culture Extract (Cs-4) on Rodent Models of Allergic Rhinitis and Asthma |
| title_full | Anti-Inflammatory Effects of a <i>Cordyceps sinensis</i> Mycelium Culture Extract (Cs-4) on Rodent Models of Allergic Rhinitis and Asthma |
| title_fullStr | Anti-Inflammatory Effects of a <i>Cordyceps sinensis</i> Mycelium Culture Extract (Cs-4) on Rodent Models of Allergic Rhinitis and Asthma |
| title_full_unstemmed | Anti-Inflammatory Effects of a <i>Cordyceps sinensis</i> Mycelium Culture Extract (Cs-4) on Rodent Models of Allergic Rhinitis and Asthma |
| title_short | Anti-Inflammatory Effects of a <i>Cordyceps sinensis</i> Mycelium Culture Extract (Cs-4) on Rodent Models of Allergic Rhinitis and Asthma |
| title_sort | anti inflammatory effects of a i cordyceps sinensis i mycelium culture extract cs 4 on rodent models of allergic rhinitis and asthma |
| topic | Cordyceps anti-inflammatory effect allergic rhinitis asthma |
| url | https://www.mdpi.com/1420-3049/25/18/4051 |
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