Adiponectin contributes to the inflammatory milieu in hidradenitis suppurativa
Introduction: Hidradenitis suppurativa (HS) is a severe chronic inflammatory skin disease. Although the pathogenesis remains unclear, at the basis of HS there is an enhancement of the immune and inflammatory response together with a susceptibility to environmental factors. Cytokines dysregulation i...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Mattioli1885
2022-10-01
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| Series: | Dermatology Practical & Conceptual |
| Subjects: | |
| Online Access: | https://www.dpcj.org/index.php/dpc/article/view/2019 |
| _version_ | 1811256057651003392 |
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| author | Ersilia Nigro Rita Polito Graziella Babino Edi Mattera Elisabetta Fulgione Giovanni Ragozzino Vittoria D'Esposito Serena Cabaro Giuseppe Signoriello Pietro Formisano Giuseppe Argenziano Aurora Daniele |
| author_facet | Ersilia Nigro Rita Polito Graziella Babino Edi Mattera Elisabetta Fulgione Giovanni Ragozzino Vittoria D'Esposito Serena Cabaro Giuseppe Signoriello Pietro Formisano Giuseppe Argenziano Aurora Daniele |
| author_sort | Ersilia Nigro |
| collection | DOAJ |
| description |
Introduction: Hidradenitis suppurativa (HS) is a severe chronic inflammatory skin disease. Although the pathogenesis remains unclear, at the basis of HS there is an enhancement of the immune and inflammatory response together with a susceptibility to environmental factors. Cytokines dysregulation is crucial in HS severity and progression.
Objectives: the aim of this study was to analyze serum levels of different cytokines focusing on adiponectin concentration and its oligomeric distribution in serum from HS patients compared to both obese and healthy subjects.
Methods: The concentrations of adiponectin and cytokines were measured using ELISA assay; the oligomeric distribution of adiponectin was evaluated through Western Blotting analysis.
Results: Total Adiponectin is statistically higher in HS patients compared to matched controls (28.54 ±4.49μg/mL vs 24.67±3.35 μg/mL, p=0.00). Interestingly, Adiponectin oligomerization state is altered in HS, with an increase of HMW oligomers. Serum levels of PDGF-BB, IL-1b, IL-5, Il-6, IL12, IL13, IL15, IL-17, GMCSF, INFg, VEGF and MCP-1 are statistically higher while IL-1ra and RANTES levels are statistically lower in HS patients compared to healthy controls. Interestingly, adiponectin positively correlates with PDGF-BB, and IL-13.
Conclusions: HS patients have a dysregulated immune homeostasis correlated with altered metabolism. Indeed, our data suggest that Adiponectin and its HMW oligomers are involved in HS representing a potential biomarker of disease. In particular, the specific correlation of adiponectin with PDGF-BB, and IL-13 extends its role in modulation of immune responses suggesting that this adipokine might act regulating the innate immune system rather that the adaptive one.
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| first_indexed | 2024-04-12T17:35:22Z |
| format | Article |
| id | doaj.art-f408c0a172a4474f9f4ce76d8521b516 |
| institution | Directory Open Access Journal |
| issn | 2160-9381 |
| language | English |
| last_indexed | 2024-04-12T17:35:22Z |
| publishDate | 2022-10-01 |
| publisher | Mattioli1885 |
| record_format | Article |
| series | Dermatology Practical & Conceptual |
| spelling | doaj.art-f408c0a172a4474f9f4ce76d8521b5162022-12-22T03:23:01ZengMattioli1885Dermatology Practical & Conceptual2160-93812022-10-0112410.5826/dpc.1204a157Adiponectin contributes to the inflammatory milieu in hidradenitis suppurativaErsilia Nigro0Rita Polito1Graziella Babino2Edi Mattera3Elisabetta Fulgione4Giovanni Ragozzino5Vittoria D'Esposito6Serena Cabaro7Giuseppe Signoriello8Pietro Formisano9Giuseppe Argenziano10Aurora Daniele11Dipartimento di Scienze e Tecnologie Ambientali, Biologiche e Farmaceutiche, Università degli Studi della Campania “Luigi Vanvitelli”, Caserta, Italy; CEINGE-Biotecnologie avanzate, Napoli, ItalyCEINGE-Biotecnologie avanzate, Napoli, ItalyDermatology Unit, Università Degli Studi della Campania "Luigi Vanvitelli", Naples, ItalyDepartment of Internal and Experimental Medicine and Surgery Unit of Internal Medicine, Università degli Studi della Campania “Luigi Vanvitelli”, NapoliDermatology Unit, Università Degli Studi della Campania "Luigi Vanvitelli", Naples, ItalyDepartment of Internal and Experimental Medicine and Surgery Unit of Internal Medicine, Università degli Studi della Campania “Luigi Vanvitelli”, NapoliDepartment of Translational Medicine, University of Naples Federico II, Naples, Italy.Department of Translational Medicine, University of Naples Federico II, Naples, ItalyDepartment of Public, Clinical and Preventive Medicine, Medical Statistics Unit, Università degli Studi della Campania "Luigi Vanvitelli", Naples, ItalyDepartment of Translational Medicine, University of Naples Federico II, Naples, Italy.Department of Internal and Experimental Medicine and Surgery Unit of Internal Medicine, Università degli Studi della Campania “Luigi Vanvitelli”, NapoliDipartimento di Scienze e Tecnologie Ambientali, Biologiche e Farmaceutiche, Università degli Studi della Campania “Luigi Vanvitelli”, Caserta, Italy; Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli «Federico II», Napoli, Italy Introduction: Hidradenitis suppurativa (HS) is a severe chronic inflammatory skin disease. Although the pathogenesis remains unclear, at the basis of HS there is an enhancement of the immune and inflammatory response together with a susceptibility to environmental factors. Cytokines dysregulation is crucial in HS severity and progression. Objectives: the aim of this study was to analyze serum levels of different cytokines focusing on adiponectin concentration and its oligomeric distribution in serum from HS patients compared to both obese and healthy subjects. Methods: The concentrations of adiponectin and cytokines were measured using ELISA assay; the oligomeric distribution of adiponectin was evaluated through Western Blotting analysis. Results: Total Adiponectin is statistically higher in HS patients compared to matched controls (28.54 ±4.49μg/mL vs 24.67±3.35 μg/mL, p=0.00). Interestingly, Adiponectin oligomerization state is altered in HS, with an increase of HMW oligomers. Serum levels of PDGF-BB, IL-1b, IL-5, Il-6, IL12, IL13, IL15, IL-17, GMCSF, INFg, VEGF and MCP-1 are statistically higher while IL-1ra and RANTES levels are statistically lower in HS patients compared to healthy controls. Interestingly, adiponectin positively correlates with PDGF-BB, and IL-13. Conclusions: HS patients have a dysregulated immune homeostasis correlated with altered metabolism. Indeed, our data suggest that Adiponectin and its HMW oligomers are involved in HS representing a potential biomarker of disease. In particular, the specific correlation of adiponectin with PDGF-BB, and IL-13 extends its role in modulation of immune responses suggesting that this adipokine might act regulating the innate immune system rather that the adaptive one. https://www.dpcj.org/index.php/dpc/article/view/2019Adiponectin, hidradenitis suppurativa, cytokines, inflammation, immune system. |
| spellingShingle | Ersilia Nigro Rita Polito Graziella Babino Edi Mattera Elisabetta Fulgione Giovanni Ragozzino Vittoria D'Esposito Serena Cabaro Giuseppe Signoriello Pietro Formisano Giuseppe Argenziano Aurora Daniele Adiponectin contributes to the inflammatory milieu in hidradenitis suppurativa Dermatology Practical & Conceptual Adiponectin, hidradenitis suppurativa, cytokines, inflammation, immune system. |
| title | Adiponectin contributes to the inflammatory milieu in hidradenitis suppurativa |
| title_full | Adiponectin contributes to the inflammatory milieu in hidradenitis suppurativa |
| title_fullStr | Adiponectin contributes to the inflammatory milieu in hidradenitis suppurativa |
| title_full_unstemmed | Adiponectin contributes to the inflammatory milieu in hidradenitis suppurativa |
| title_short | Adiponectin contributes to the inflammatory milieu in hidradenitis suppurativa |
| title_sort | adiponectin contributes to the inflammatory milieu in hidradenitis suppurativa |
| topic | Adiponectin, hidradenitis suppurativa, cytokines, inflammation, immune system. |
| url | https://www.dpcj.org/index.php/dpc/article/view/2019 |
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