| Summary: | Hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) as a crucial signal molecule plays a vital part in the growth and development of various cells under normal physiological conditions. The development of H<sub>2</sub>O<sub>2</sub> sensors has received great research interest because of the importance of H<sub>2</sub>O<sub>2</sub> in biological systems and its practical applications in other fields. In this study, a H<sub>2</sub>O<sub>2</sub> electrochemical sensor was constructed based on chalcogenide molybdenum disulfide–gold–silver nanocomposite (MoS<sub>2</sub>-Au-Ag). Transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS) and energy dispersive spectroscopy (EDS) were utilized to characterize the nanocomposites, and the electrochemical performances of the obtained sensor were assessed by two electrochemical detection methods: cyclic voltammetry and chronoamperometry. The results showed that the MoS<sub>2</sub>-Au-Ag-modified glassy carbon electrode (GCE) has higher sensitivity (405.24 µA mM<sup>−1</sup> cm<sup>−2</sup>), wider linear detection range (0.05–20 mM) and satisfactory repeatability and stability. Moreover, the prepared sensor was able to detect the H<sub>2</sub>O<sub>2</sub> discharge from living tumor cells. Therefore, this study offers a platform for the early diagnosis of cancer and other applications in the fields of biology and biomedicine.
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