Aberrant expression of interleukin-23-regulated miRNAs in T cells from patients with ankylosing spondylitis

Aberrant expression of interleukin-23-regulated miRNAs in T cells from patients with ankylosing spondylitis

Abstract Background Interleukin (IL)-23 can facilitate the differentiation of IL-17-producing helper T cells (Th17). The IL-23/IL-17 axis is known to play a key role in the immunopathogenesis of ankylosing spondylitis (AS). We hypothesized that the expression of microRNAs (miRNAs, miRs) would be reg...

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Bibliographic Details
Main Authors: Ning-Sheng Lai, Hui-Chun Yu, Chien-Hsueh Tung, Kuang-Yung Huang, Hsien-Bin Huang, Ming-Chi Lu
Format: Article
Language:English
Published: BMC 2018-11-01
Series:Arthritis Research & Therapy
Subjects:
Ankylosing spondylitis
IL-23
T cells
MicroRNAs
STAT3
Angiogenin
Online Access:http://link.springer.com/article/10.1186/s13075-018-1754-1

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