ADOPTIVE CELL THERAPY: CURRENT ADVANCES
The immune system plays an important role in the development and treatment of many cancer types. This fact determined the emergence of numerous immunotherapeutic approaches, including that of adoptive cell therapy (ACT). In this article, we set out to describe the basic methods of adoptive cell canc...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | Russian |
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ANO "Perspective of oncology"
2020-03-01
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| Series: | Южно-Российский онкологический журнал |
| Subjects: | |
| Online Access: | https://www.cancersp.com/jour/article/view/40 |
| _version_ | 1826573083736014848 |
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| author | T. V. Shamova A. O. Sitkovskaya L. N. Vashchenko E. E. Kechedzhieva |
| author_facet | T. V. Shamova A. O. Sitkovskaya L. N. Vashchenko E. E. Kechedzhieva |
| author_sort | T. V. Shamova |
| collection | DOAJ |
| description | The immune system plays an important role in the development and treatment of many cancer types. This fact determined the emergence of numerous immunotherapeutic approaches, including that of adoptive cell therapy (ACT). In this article, we set out to describe the basic methods of adoptive cell cancer therapy, their application and development prospects. The first part of the article deals with the significance of immunotherapeutic methods for cancer treatment and describes the current state of the problem. The main part of the article provides information on the mechanisms of adoptive T cell (unmodified and genetically modified) transfer, the creation of dendritic cell vaccines and cytokine-induced killers (CIK). In addition, a review of recent achievements in the introduction of the aforementioned methods into the clinical practice is carried out. The conclusion is made that adoptive cell therapy can be considered as one of the most promising methods of cancer immunotherapy, which should be optimized for more effective use in the treatment of cancer. |
| first_indexed | 2024-04-10T03:42:12Z |
| format | Article |
| id | doaj.art-f40bea7510af4cf8a9dd69fd9fbccc52 |
| institution | Directory Open Access Journal |
| issn | 2686-9039 |
| language | Russian |
| last_indexed | 2025-03-14T12:37:16Z |
| publishDate | 2020-03-01 |
| publisher | ANO "Perspective of oncology" |
| record_format | Article |
| series | Южно-Российский онкологический журнал |
| spelling | doaj.art-f40bea7510af4cf8a9dd69fd9fbccc522025-03-02T09:21:50ZrusANO "Perspective of oncology"Южно-Российский онкологический журнал2686-90392020-03-0111435910.37748/2687-0533-2020-1-1-44ADOPTIVE CELL THERAPY: CURRENT ADVANCEST. V. Shamova0A. O. Sitkovskaya1L. N. Vashchenko2E. E. Kechedzhieva3National Medical Research Centre for OncologyNational Medical Research Centre for OncologyNational Medical Research Centre for OncologyNational Medical Research Centre for OncologyThe immune system plays an important role in the development and treatment of many cancer types. This fact determined the emergence of numerous immunotherapeutic approaches, including that of adoptive cell therapy (ACT). In this article, we set out to describe the basic methods of adoptive cell cancer therapy, their application and development prospects. The first part of the article deals with the significance of immunotherapeutic methods for cancer treatment and describes the current state of the problem. The main part of the article provides information on the mechanisms of adoptive T cell (unmodified and genetically modified) transfer, the creation of dendritic cell vaccines and cytokine-induced killers (CIK). In addition, a review of recent achievements in the introduction of the aforementioned methods into the clinical practice is carried out. The conclusion is made that adoptive cell therapy can be considered as one of the most promising methods of cancer immunotherapy, which should be optimized for more effective use in the treatment of cancer.https://www.cancersp.com/jour/article/view/40oncologycancer immunotherapyadoptive cell therapytumour-infiltrating lymphocytesdendritic cells vaccinescytokine-induced killers |
| spellingShingle | T. V. Shamova A. O. Sitkovskaya L. N. Vashchenko E. E. Kechedzhieva ADOPTIVE CELL THERAPY: CURRENT ADVANCES Южно-Российский онкологический журнал oncology cancer immunotherapy adoptive cell therapy tumour-infiltrating lymphocytes dendritic cells vaccines cytokine-induced killers |
| title | ADOPTIVE CELL THERAPY: CURRENT ADVANCES |
| title_full | ADOPTIVE CELL THERAPY: CURRENT ADVANCES |
| title_fullStr | ADOPTIVE CELL THERAPY: CURRENT ADVANCES |
| title_full_unstemmed | ADOPTIVE CELL THERAPY: CURRENT ADVANCES |
| title_short | ADOPTIVE CELL THERAPY: CURRENT ADVANCES |
| title_sort | adoptive cell therapy current advances |
| topic | oncology cancer immunotherapy adoptive cell therapy tumour-infiltrating lymphocytes dendritic cells vaccines cytokine-induced killers |
| url | https://www.cancersp.com/jour/article/view/40 |
| work_keys_str_mv | AT tvshamova adoptivecelltherapycurrentadvances AT aositkovskaya adoptivecelltherapycurrentadvances AT lnvashchenko adoptivecelltherapycurrentadvances AT eekechedzhieva adoptivecelltherapycurrentadvances |