Autophagy receptors as viral targets
Abstract Activation of autophagy is part of the innate immune response during viral infections. Autophagy involves the sequestration of endogenous or foreign components from the cytosol within double-membraned vesicles and the delivery of their content to the lysosomes for degradation. As part of in...
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| Format: | Article |
| Language: | English |
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BMC
2021-06-01
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| Series: | Cellular & Molecular Biology Letters |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s11658-021-00272-x |
| _version_ | 1818657187774332928 |
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| author | Päivi Ylä-Anttila |
| author_facet | Päivi Ylä-Anttila |
| author_sort | Päivi Ylä-Anttila |
| collection | DOAJ |
| description | Abstract Activation of autophagy is part of the innate immune response during viral infections. Autophagy involves the sequestration of endogenous or foreign components from the cytosol within double-membraned vesicles and the delivery of their content to the lysosomes for degradation. As part of innate immune responses, this autophagic elimination of foreign components is selective and requires specialized cargo receptors that function as links between a tagged foreign component and the autophagic machinery. Pathogens have evolved ways to evade their autophagic degradation to promote their replication, and recent research has shown autophagic receptors to be an important and perhaps previously overlooked target of viral autophagy inhibition. This is a brief summary of the recent progress in knowledge of virus-host interaction in the context of autophagy receptors. |
| first_indexed | 2024-12-17T03:37:30Z |
| format | Article |
| id | doaj.art-f40c02eb0a45468aa38089161e890ed8 |
| institution | Directory Open Access Journal |
| issn | 1425-8153 1689-1392 |
| language | English |
| last_indexed | 2024-12-17T03:37:30Z |
| publishDate | 2021-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Cellular & Molecular Biology Letters |
| spelling | doaj.art-f40c02eb0a45468aa38089161e890ed82022-12-21T22:05:06ZengBMCCellular & Molecular Biology Letters1425-81531689-13922021-06-0126111110.1186/s11658-021-00272-xAutophagy receptors as viral targetsPäivi Ylä-Anttila0Department of Cell and Molecular Biology, Karolinska InstitutetAbstract Activation of autophagy is part of the innate immune response during viral infections. Autophagy involves the sequestration of endogenous or foreign components from the cytosol within double-membraned vesicles and the delivery of their content to the lysosomes for degradation. As part of innate immune responses, this autophagic elimination of foreign components is selective and requires specialized cargo receptors that function as links between a tagged foreign component and the autophagic machinery. Pathogens have evolved ways to evade their autophagic degradation to promote their replication, and recent research has shown autophagic receptors to be an important and perhaps previously overlooked target of viral autophagy inhibition. This is a brief summary of the recent progress in knowledge of virus-host interaction in the context of autophagy receptors.https://doi.org/10.1186/s11658-021-00272-xAutophagyInfectionReceptorVirusesCargoXenophagy |
| spellingShingle | Päivi Ylä-Anttila Autophagy receptors as viral targets Cellular & Molecular Biology Letters Autophagy Infection Receptor Viruses Cargo Xenophagy |
| title | Autophagy receptors as viral targets |
| title_full | Autophagy receptors as viral targets |
| title_fullStr | Autophagy receptors as viral targets |
| title_full_unstemmed | Autophagy receptors as viral targets |
| title_short | Autophagy receptors as viral targets |
| title_sort | autophagy receptors as viral targets |
| topic | Autophagy Infection Receptor Viruses Cargo Xenophagy |
| url | https://doi.org/10.1186/s11658-021-00272-x |
| work_keys_str_mv | AT paiviylaanttila autophagyreceptorsasviraltargets |