Diet-induced obesity impairs spermatogenesis: the critical role of NLRP3 in Sertoli cells

Diet-induced obesity impairs spermatogenesis: the critical role of NLRP3 in Sertoli cells

Abstract Background Accumulating evidence indicates a key role of Sertoli cell (SC) malfunction in spermatogenesis impairment induced by obesity. Nucleotide-binding oligomerization domain-like receptor with a pyrin domain 3 (NLRP3) is expressed in SCs, but the role of NLRP3 in the pathological proce...

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Bibliographic Details
Main Authors: Yang Mu, Tai-lang Yin, Yan Zhang, Jing Yang, Yan-ting Wu
Format: Article
Language:English
Published: BMC 2022-08-01
Series:Inflammation and Regeneration
Subjects:
AMPKα
MicroRNA
NLRP3, Obesity
Sertoli cells
Online Access:https://doi.org/10.1186/s41232-022-00203-z

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