TLR induces reorganization of the IgM-BCR complex regulating murine B-1 cell responses to infections
In mice, neonatally-developing, self-reactive B-1 cells generate steady levels of natural antibodies throughout life. B-1 cells can, however, also rapidly respond to infections with increased local antibody production. The mechanisms regulating these two seemingly very distinct functions are poorly...
Main Authors: | Hannah P Savage, Kathrin Kläsener, Fauna L Smith, Zheng Luo, Michael Reth, Nicole Baumgarth |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2019-08-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/46997 |
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