The protective effect of Tilia amurensis honey on influenza A virus infection through stimulation of interferon-mediated IFITM3 signaling
Recently, attention has focused on the prevention and treatment of respiratory viruses including influenza viruses. We evaluated the antiviral effect of Tilia amurensis honey (TH) against influenza A virus in murine macrophages. Influenza A virus infection was reduced following pretreatment with TH....
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-09-01
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| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332222006485 |
| _version_ | 1811188122268991488 |
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| author | Eun-Bin Kwon Young Soo Kim Sang Mi Han Se-Gun Kim Jang-Gi Choi |
| author_facet | Eun-Bin Kwon Young Soo Kim Sang Mi Han Se-Gun Kim Jang-Gi Choi |
| author_sort | Eun-Bin Kwon |
| collection | DOAJ |
| description | Recently, attention has focused on the prevention and treatment of respiratory viruses including influenza viruses. We evaluated the antiviral effect of Tilia amurensis honey (TH) against influenza A virus in murine macrophages. Influenza A virus infection was reduced following pretreatment with TH. Pretreatment of murine macrophages with TH increased the production and secretion of type-1 interferon (IFN) and proinflammatory cytokines and increased phosphorylation of the type-1 IFN-related proteins, TANK-binding kinase (TBK), and STAT. Moreover, TH increased the expression of IFN-stimulating genes and increased the expression of IFN-inducible transmembrane (IFITM3), a protein that interferes with virus replication and entry. Taken together, these findings suggest that TH suppresses influenza A virus infection by regulating the innate immune response in macrophages. This supports the development of preventive and therapeutic agents for influenza A virus and enhances the economic value of TH. |
| first_indexed | 2024-04-11T14:14:10Z |
| format | Article |
| id | doaj.art-f40dd99f2dbe4f5fa55a94dea9a0f7f8 |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-04-11T14:14:10Z |
| publishDate | 2022-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-f40dd99f2dbe4f5fa55a94dea9a0f7f82022-12-22T04:19:36ZengElsevierBiomedicine & Pharmacotherapy0753-33222022-09-01153113259The protective effect of Tilia amurensis honey on influenza A virus infection through stimulation of interferon-mediated IFITM3 signalingEun-Bin Kwon0Young Soo Kim1Sang Mi Han2Se-Gun Kim3Jang-Gi Choi4Korean Medicine (KM) Application Center, Korea Institute of Oriental Medicine, Daegu 41062, Republic of KoreaKorean Medicine (KM) Application Center, Korea Institute of Oriental Medicine, Daegu 41062, Republic of KoreaDepartment of Agricultural Biology, National Institute of Agricultural Science, Rural Development Administration, Wanju 55365, KoreaDepartment of Agricultural Biology, National Institute of Agricultural Science, Rural Development Administration, Wanju 55365, KoreaKorean Medicine (KM) Application Center, Korea Institute of Oriental Medicine, Daegu 41062, Republic of Korea; Corresponding author.Recently, attention has focused on the prevention and treatment of respiratory viruses including influenza viruses. We evaluated the antiviral effect of Tilia amurensis honey (TH) against influenza A virus in murine macrophages. Influenza A virus infection was reduced following pretreatment with TH. Pretreatment of murine macrophages with TH increased the production and secretion of type-1 interferon (IFN) and proinflammatory cytokines and increased phosphorylation of the type-1 IFN-related proteins, TANK-binding kinase (TBK), and STAT. Moreover, TH increased the expression of IFN-stimulating genes and increased the expression of IFN-inducible transmembrane (IFITM3), a protein that interferes with virus replication and entry. Taken together, these findings suggest that TH suppresses influenza A virus infection by regulating the innate immune response in macrophages. This supports the development of preventive and therapeutic agents for influenza A virus and enhances the economic value of TH.http://www.sciencedirect.com/science/article/pii/S0753332222006485Tilia amurensis honeyInfluenza A virusInterferonISGsIFITM3 |
| spellingShingle | Eun-Bin Kwon Young Soo Kim Sang Mi Han Se-Gun Kim Jang-Gi Choi The protective effect of Tilia amurensis honey on influenza A virus infection through stimulation of interferon-mediated IFITM3 signaling Biomedicine & Pharmacotherapy Tilia amurensis honey Influenza A virus Interferon ISGs IFITM3 |
| title | The protective effect of Tilia amurensis honey on influenza A virus infection through stimulation of interferon-mediated IFITM3 signaling |
| title_full | The protective effect of Tilia amurensis honey on influenza A virus infection through stimulation of interferon-mediated IFITM3 signaling |
| title_fullStr | The protective effect of Tilia amurensis honey on influenza A virus infection through stimulation of interferon-mediated IFITM3 signaling |
| title_full_unstemmed | The protective effect of Tilia amurensis honey on influenza A virus infection through stimulation of interferon-mediated IFITM3 signaling |
| title_short | The protective effect of Tilia amurensis honey on influenza A virus infection through stimulation of interferon-mediated IFITM3 signaling |
| title_sort | protective effect of tilia amurensis honey on influenza a virus infection through stimulation of interferon mediated ifitm3 signaling |
| topic | Tilia amurensis honey Influenza A virus Interferon ISGs IFITM3 |
| url | http://www.sciencedirect.com/science/article/pii/S0753332222006485 |
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