Comparative Effectiveness and Persistence of Antimicrobial Durability in Dry and Wet States of a Novel Antimicrobial Surface Disinfectant
<b>Aims:</b> We evaluated a novel disinfectant (VR) and seven comparators (disinfectants A–G) against resistant pathogens common in healthcare settings. <b>Methods and Results:</b> VR at different dilutions, along with commercial disinfectants A–G, was tested against surrogat...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Applied Microbiology |
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| Online Access: | https://www.mdpi.com/2673-8007/3/2/39 |
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| author | Bahgat Gerges Joel Rosenblatt Ying Jiang Issam Raad |
| author_facet | Bahgat Gerges Joel Rosenblatt Ying Jiang Issam Raad |
| author_sort | Bahgat Gerges |
| collection | DOAJ |
| description | <b>Aims:</b> We evaluated a novel disinfectant (VR) and seven comparators (disinfectants A–G) against resistant pathogens common in healthcare settings. <b>Methods and Results:</b> VR at different dilutions, along with commercial disinfectants A–G, was tested against surrogate viruses, and resistant bacterial and fungal pathogens. Surrogate viruses had an initial concentration of ~1 × 10<sup>8</sup> mL<sup>−1</sup>, and bacterial and fungal isolates had an initial concentration of ~1 × 10<sup>6</sup> mL<sup>−1</sup> on Siliconee surfaces. After the application of VR or a comparator disinfectant, surfaces were tested for the reduction in microbial loads after 30 s and 5 min wet exposures, and after a 24 h dry residue exposure. Sterile deionized water was used as a control. The VR at a concentration of 4.68% was superior to all comparator disinfectants against most pathogens in wet and dry testing. The VR at 7.8% concentration showed the highest pathogen-reduction rate among all comparator disinfectants when tested against all pathogens. <b>Conclusions:</b> Overall, the novel VR disinfectant was the most effective disinfectant in both wet and dry residue states against the range of tested pathogens. <b>Significance and Impact of the Study:</b> VR is a broadly effective disinfectant combination for use in high-risk settings, particularly those in which intervals between applications of disinfectant can be lengthy or inconsistent. |
| first_indexed | 2024-03-11T02:50:14Z |
| format | Article |
| id | doaj.art-f40e1cbe14ed4e66b67e8caaef9d281a |
| institution | Directory Open Access Journal |
| issn | 2673-8007 |
| language | English |
| last_indexed | 2024-03-11T02:50:14Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Microbiology |
| spelling | doaj.art-f40e1cbe14ed4e66b67e8caaef9d281a2023-11-18T09:05:25ZengMDPI AGApplied Microbiology2673-80072023-06-013254956110.3390/applmicrobiol3020039Comparative Effectiveness and Persistence of Antimicrobial Durability in Dry and Wet States of a Novel Antimicrobial Surface DisinfectantBahgat Gerges0Joel Rosenblatt1Ying Jiang2Issam Raad3Department of Infectious Diseases, Infection Control and Employee Health Research, The University of Texas MD Anderson Cancer Center, 1515 Holcomb Blvd, Houston, TX 77003, USADepartment of Infectious Diseases, Infection Control and Employee Health Research, The University of Texas MD Anderson Cancer Center, 1515 Holcomb Blvd, Houston, TX 77003, USADepartment of Infectious Diseases, Infection Control and Employee Health Research, The University of Texas MD Anderson Cancer Center, 1515 Holcomb Blvd, Houston, TX 77003, USADepartment of Infectious Diseases, Infection Control and Employee Health Research, The University of Texas MD Anderson Cancer Center, 1515 Holcomb Blvd, Houston, TX 77003, USA<b>Aims:</b> We evaluated a novel disinfectant (VR) and seven comparators (disinfectants A–G) against resistant pathogens common in healthcare settings. <b>Methods and Results:</b> VR at different dilutions, along with commercial disinfectants A–G, was tested against surrogate viruses, and resistant bacterial and fungal pathogens. Surrogate viruses had an initial concentration of ~1 × 10<sup>8</sup> mL<sup>−1</sup>, and bacterial and fungal isolates had an initial concentration of ~1 × 10<sup>6</sup> mL<sup>−1</sup> on Siliconee surfaces. After the application of VR or a comparator disinfectant, surfaces were tested for the reduction in microbial loads after 30 s and 5 min wet exposures, and after a 24 h dry residue exposure. Sterile deionized water was used as a control. The VR at a concentration of 4.68% was superior to all comparator disinfectants against most pathogens in wet and dry testing. The VR at 7.8% concentration showed the highest pathogen-reduction rate among all comparator disinfectants when tested against all pathogens. <b>Conclusions:</b> Overall, the novel VR disinfectant was the most effective disinfectant in both wet and dry residue states against the range of tested pathogens. <b>Significance and Impact of the Study:</b> VR is a broadly effective disinfectant combination for use in high-risk settings, particularly those in which intervals between applications of disinfectant can be lengthy or inconsistent.https://www.mdpi.com/2673-8007/3/2/39novel disinfectantsantimicrobial durabilityPHMBtetrasodium EDTAdry and wet testing |
| spellingShingle | Bahgat Gerges Joel Rosenblatt Ying Jiang Issam Raad Comparative Effectiveness and Persistence of Antimicrobial Durability in Dry and Wet States of a Novel Antimicrobial Surface Disinfectant Applied Microbiology novel disinfectants antimicrobial durability PHMB tetrasodium EDTA dry and wet testing |
| title | Comparative Effectiveness and Persistence of Antimicrobial Durability in Dry and Wet States of a Novel Antimicrobial Surface Disinfectant |
| title_full | Comparative Effectiveness and Persistence of Antimicrobial Durability in Dry and Wet States of a Novel Antimicrobial Surface Disinfectant |
| title_fullStr | Comparative Effectiveness and Persistence of Antimicrobial Durability in Dry and Wet States of a Novel Antimicrobial Surface Disinfectant |
| title_full_unstemmed | Comparative Effectiveness and Persistence of Antimicrobial Durability in Dry and Wet States of a Novel Antimicrobial Surface Disinfectant |
| title_short | Comparative Effectiveness and Persistence of Antimicrobial Durability in Dry and Wet States of a Novel Antimicrobial Surface Disinfectant |
| title_sort | comparative effectiveness and persistence of antimicrobial durability in dry and wet states of a novel antimicrobial surface disinfectant |
| topic | novel disinfectants antimicrobial durability PHMB tetrasodium EDTA dry and wet testing |
| url | https://www.mdpi.com/2673-8007/3/2/39 |
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