Cerebellar rTMS and PAS effectively induce cerebellar plasticity
Abstract Non-invasive brain stimulation techniques including repetitive transcranial magnetic stimulation (rTMS), continuous theta-burst stimulation (cTBS), paired associative stimulation (PAS), and transcranial direct current stimulation (tDCS) have been applied over the cerebellum to induce plasti...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-02-01
|
| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-82496-7 |
| _version_ | 1818839906426814464 |
|---|---|
| author | Martje G. Pauly Annika Steinmeier Christina Bolte Feline Hamami Elinor Tzvi Alexander Münchau Tobias Bäumer Anne Weissbach |
| author_facet | Martje G. Pauly Annika Steinmeier Christina Bolte Feline Hamami Elinor Tzvi Alexander Münchau Tobias Bäumer Anne Weissbach |
| author_sort | Martje G. Pauly |
| collection | DOAJ |
| description | Abstract Non-invasive brain stimulation techniques including repetitive transcranial magnetic stimulation (rTMS), continuous theta-burst stimulation (cTBS), paired associative stimulation (PAS), and transcranial direct current stimulation (tDCS) have been applied over the cerebellum to induce plasticity and gain insights into the interaction of the cerebellum with neo-cortical structures including the motor cortex. We compared the effects of 1 Hz rTMS, cTBS, PAS and tDCS given over the cerebellum on motor cortical excitability and interactions between the cerebellum and dorsal premotor cortex / primary motor cortex in two within subject designs in healthy controls. In experiment 1, rTMS, cTBS, PAS, and tDCS were applied over the cerebellum in 20 healthy subjects. In experiment 2, rTMS and PAS were compared to sham conditions in another group of 20 healthy subjects. In experiment 1, PAS reduced cortical excitability determined by motor evoked potentials (MEP) amplitudes, whereas rTMS increased motor thresholds and facilitated dorsal premotor-motor and cerebellum-motor cortex interactions. TDCS and cTBS had no significant effects. In experiment 2, MEP amplitudes increased after rTMS and motor thresholds following PAS. Analysis of all participants who received rTMS and PAS showed that MEP amplitudes were reduced after PAS and increased following rTMS. rTMS also caused facilitation of dorsal premotor-motor cortex and cerebellum-motor cortex interactions. In summary, cerebellar 1 Hz rTMS and PAS can effectively induce plasticity in cerebello-(premotor)-motor pathways provided larger samples are studied. |
| first_indexed | 2024-12-19T04:01:44Z |
| format | Article |
| id | doaj.art-f40ffea0e82d424381acfa3cd506b2f2 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-19T04:01:44Z |
| publishDate | 2021-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-f40ffea0e82d424381acfa3cd506b2f22022-12-21T20:36:39ZengNature PortfolioScientific Reports2045-23222021-02-0111111310.1038/s41598-021-82496-7Cerebellar rTMS and PAS effectively induce cerebellar plasticityMartje G. Pauly0Annika Steinmeier1Christina Bolte2Feline Hamami3Elinor Tzvi4Alexander Münchau5Tobias Bäumer6Anne Weissbach7Institute of Systems Motor Science, University of LübeckInstitute of Systems Motor Science, University of LübeckInstitute of Systems Motor Science, University of LübeckInstitute of Systems Motor Science, University of LübeckDepartment of Neurology, University of LeipzigInstitute of Systems Motor Science, University of LübeckInstitute of Systems Motor Science, University of LübeckInstitute of Systems Motor Science, University of LübeckAbstract Non-invasive brain stimulation techniques including repetitive transcranial magnetic stimulation (rTMS), continuous theta-burst stimulation (cTBS), paired associative stimulation (PAS), and transcranial direct current stimulation (tDCS) have been applied over the cerebellum to induce plasticity and gain insights into the interaction of the cerebellum with neo-cortical structures including the motor cortex. We compared the effects of 1 Hz rTMS, cTBS, PAS and tDCS given over the cerebellum on motor cortical excitability and interactions between the cerebellum and dorsal premotor cortex / primary motor cortex in two within subject designs in healthy controls. In experiment 1, rTMS, cTBS, PAS, and tDCS were applied over the cerebellum in 20 healthy subjects. In experiment 2, rTMS and PAS were compared to sham conditions in another group of 20 healthy subjects. In experiment 1, PAS reduced cortical excitability determined by motor evoked potentials (MEP) amplitudes, whereas rTMS increased motor thresholds and facilitated dorsal premotor-motor and cerebellum-motor cortex interactions. TDCS and cTBS had no significant effects. In experiment 2, MEP amplitudes increased after rTMS and motor thresholds following PAS. Analysis of all participants who received rTMS and PAS showed that MEP amplitudes were reduced after PAS and increased following rTMS. rTMS also caused facilitation of dorsal premotor-motor cortex and cerebellum-motor cortex interactions. In summary, cerebellar 1 Hz rTMS and PAS can effectively induce plasticity in cerebello-(premotor)-motor pathways provided larger samples are studied.https://doi.org/10.1038/s41598-021-82496-7 |
| spellingShingle | Martje G. Pauly Annika Steinmeier Christina Bolte Feline Hamami Elinor Tzvi Alexander Münchau Tobias Bäumer Anne Weissbach Cerebellar rTMS and PAS effectively induce cerebellar plasticity Scientific Reports |
| title | Cerebellar rTMS and PAS effectively induce cerebellar plasticity |
| title_full | Cerebellar rTMS and PAS effectively induce cerebellar plasticity |
| title_fullStr | Cerebellar rTMS and PAS effectively induce cerebellar plasticity |
| title_full_unstemmed | Cerebellar rTMS and PAS effectively induce cerebellar plasticity |
| title_short | Cerebellar rTMS and PAS effectively induce cerebellar plasticity |
| title_sort | cerebellar rtms and pas effectively induce cerebellar plasticity |
| url | https://doi.org/10.1038/s41598-021-82496-7 |
| work_keys_str_mv | AT martjegpauly cerebellarrtmsandpaseffectivelyinducecerebellarplasticity AT annikasteinmeier cerebellarrtmsandpaseffectivelyinducecerebellarplasticity AT christinabolte cerebellarrtmsandpaseffectivelyinducecerebellarplasticity AT felinehamami cerebellarrtmsandpaseffectivelyinducecerebellarplasticity AT elinortzvi cerebellarrtmsandpaseffectivelyinducecerebellarplasticity AT alexandermunchau cerebellarrtmsandpaseffectivelyinducecerebellarplasticity AT tobiasbaumer cerebellarrtmsandpaseffectivelyinducecerebellarplasticity AT anneweissbach cerebellarrtmsandpaseffectivelyinducecerebellarplasticity |