Targeting Macrophages in Cancer: From Bench to Bedside
Macrophages are a major component of the tumor microenvironment and orchestrate various aspects of immunity. Within tumors, macrophages can reversibly alter their endotype in response to environmental cues, including hypoxia and stimuli derived from other immune cells, as well as the extracellular m...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-03-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/article/10.3389/fonc.2018.00049/full |
| _version_ | 1811199726546059264 |
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| author | Ashleigh R. Poh Matthias Ernst |
| author_facet | Ashleigh R. Poh Matthias Ernst |
| author_sort | Ashleigh R. Poh |
| collection | DOAJ |
| description | Macrophages are a major component of the tumor microenvironment and orchestrate various aspects of immunity. Within tumors, macrophages can reversibly alter their endotype in response to environmental cues, including hypoxia and stimuli derived from other immune cells, as well as the extracellular matrix. Depending on their activation status, macrophages can exert dual influences on tumorigenesis by either antagonizing the cytotoxic activity immune cells or by enhancing antitumor responses. In most solid cancers, increased infiltration with tumor-associated macrophages (TAMs) has long been associated with poor patient prognosis, highlighting their value as potential diagnostic and prognostic biomarkers in cancer. A number of macrophage-centered approaches to anticancer therapy have been investigated, and include strategies to block their tumor-promoting activities or exploit their antitumor effector functions. Integrating therapeutic strategies to target TAMs to complement conventional therapies has yielded promising results in preclinical trials and warrants further investigation to determine its translational benefit in human cancer patients. In this review, we discuss the molecular mechanisms underlying the pro-tumorigenic programming of macrophages and provide a comprehensive update of macrophage-targeted therapies for the treatment of solid cancers. |
| first_indexed | 2024-04-12T01:53:15Z |
| format | Article |
| id | doaj.art-f410ccaf847247bbbccbfd8b768c41eb |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-12T01:53:15Z |
| publishDate | 2018-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-f410ccaf847247bbbccbfd8b768c41eb2022-12-22T03:52:53ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2018-03-01810.3389/fonc.2018.00049343581Targeting Macrophages in Cancer: From Bench to BedsideAshleigh R. Poh0Matthias Ernst1Olivia Newton-John Cancer Research Institute, and La Trobe University School of Cancer Medicine, Heidelberg, VIC, AustraliaOlivia Newton-John Cancer Research Institute, and La Trobe University School of Cancer Medicine, Heidelberg, VIC, AustraliaMacrophages are a major component of the tumor microenvironment and orchestrate various aspects of immunity. Within tumors, macrophages can reversibly alter their endotype in response to environmental cues, including hypoxia and stimuli derived from other immune cells, as well as the extracellular matrix. Depending on their activation status, macrophages can exert dual influences on tumorigenesis by either antagonizing the cytotoxic activity immune cells or by enhancing antitumor responses. In most solid cancers, increased infiltration with tumor-associated macrophages (TAMs) has long been associated with poor patient prognosis, highlighting their value as potential diagnostic and prognostic biomarkers in cancer. A number of macrophage-centered approaches to anticancer therapy have been investigated, and include strategies to block their tumor-promoting activities or exploit their antitumor effector functions. Integrating therapeutic strategies to target TAMs to complement conventional therapies has yielded promising results in preclinical trials and warrants further investigation to determine its translational benefit in human cancer patients. In this review, we discuss the molecular mechanisms underlying the pro-tumorigenic programming of macrophages and provide a comprehensive update of macrophage-targeted therapies for the treatment of solid cancers.http://journal.frontiersin.org/article/10.3389/fonc.2018.00049/fullmacrophagesimmunotherapymacrophage polarizationinflammationcancer |
| spellingShingle | Ashleigh R. Poh Matthias Ernst Targeting Macrophages in Cancer: From Bench to Bedside Frontiers in Oncology macrophages immunotherapy macrophage polarization inflammation cancer |
| title | Targeting Macrophages in Cancer: From Bench to Bedside |
| title_full | Targeting Macrophages in Cancer: From Bench to Bedside |
| title_fullStr | Targeting Macrophages in Cancer: From Bench to Bedside |
| title_full_unstemmed | Targeting Macrophages in Cancer: From Bench to Bedside |
| title_short | Targeting Macrophages in Cancer: From Bench to Bedside |
| title_sort | targeting macrophages in cancer from bench to bedside |
| topic | macrophages immunotherapy macrophage polarization inflammation cancer |
| url | http://journal.frontiersin.org/article/10.3389/fonc.2018.00049/full |
| work_keys_str_mv | AT ashleighrpoh targetingmacrophagesincancerfrombenchtobedside AT matthiasernst targetingmacrophagesincancerfrombenchtobedside |