Stromal PTEN determines mammary epithelial response to radiotherapy
The tumor microenvironment influences tumor progression. Here the authors show that lack of stromal PTEN phosphatase induces DNA repair defects in the neighboring mammary gland epithelial cells via hyperactivation of EGF-receptor signaling, resulting in higher radiation-induced DNA damage and hyperp...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2018-07-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-05266-6 |
| _version_ | 1818841533677305856 |
|---|---|
| author | Gina M. Sizemore Subhasree Balakrishnan Katie A. Thies Anisha M. Hammer Steven T. Sizemore Anthony J. Trimboli Maria C. Cuitiño Sarah A. Steck Gary Tozbikian Raleigh D. Kladney Neelam Shinde Manjusri Das Dongju Park Sarmila Majumder Shiva Krishnan Lianbo Yu Soledad A. Fernandez Arnab Chakravarti Peter G. Shields Julia R. White Lisa D. Yee Thomas J. Rosol Thomas Ludwig Morag Park Gustavo Leone Michael C. Ostrowski |
| author_facet | Gina M. Sizemore Subhasree Balakrishnan Katie A. Thies Anisha M. Hammer Steven T. Sizemore Anthony J. Trimboli Maria C. Cuitiño Sarah A. Steck Gary Tozbikian Raleigh D. Kladney Neelam Shinde Manjusri Das Dongju Park Sarmila Majumder Shiva Krishnan Lianbo Yu Soledad A. Fernandez Arnab Chakravarti Peter G. Shields Julia R. White Lisa D. Yee Thomas J. Rosol Thomas Ludwig Morag Park Gustavo Leone Michael C. Ostrowski |
| author_sort | Gina M. Sizemore |
| collection | DOAJ |
| description | The tumor microenvironment influences tumor progression. Here the authors show that lack of stromal PTEN phosphatase induces DNA repair defects in the neighboring mammary gland epithelial cells via hyperactivation of EGF-receptor signaling, resulting in higher radiation-induced DNA damage and hyperplasia. |
| first_indexed | 2024-12-19T04:27:36Z |
| format | Article |
| id | doaj.art-f4113fd816a74125b1e376f6cb322dab |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T04:27:36Z |
| publishDate | 2018-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-f4113fd816a74125b1e376f6cb322dab2022-12-21T20:35:59ZengNature PortfolioNature Communications2041-17232018-07-019111410.1038/s41467-018-05266-6Stromal PTEN determines mammary epithelial response to radiotherapyGina M. Sizemore0Subhasree Balakrishnan1Katie A. Thies2Anisha M. Hammer3Steven T. Sizemore4Anthony J. Trimboli5Maria C. Cuitiño6Sarah A. Steck7Gary Tozbikian8Raleigh D. Kladney9Neelam Shinde10Manjusri Das11Dongju Park12Sarmila Majumder13Shiva Krishnan14Lianbo Yu15Soledad A. Fernandez16Arnab Chakravarti17Peter G. Shields18Julia R. White19Lisa D. Yee20Thomas J. Rosol21Thomas Ludwig22Morag Park23Gustavo Leone24Michael C. Ostrowski25The Comprehensive Cancer Center, The Ohio State UniversityThe Comprehensive Cancer Center, The Ohio State UniversityHollings Cancer Center, Medical University of South CarolinaThe Comprehensive Cancer Center, The Ohio State UniversityThe Comprehensive Cancer Center, The Ohio State UniversityHollings Cancer Center, Medical University of South CarolinaHollings Cancer Center, Medical University of South CarolinaThe Comprehensive Cancer Center, The Ohio State UniversityDepartment of Pathology, The Ohio State University Wexner Medical CenterThe Comprehensive Cancer Center, The Ohio State UniversityThe Comprehensive Cancer Center, The Ohio State UniversityThe Comprehensive Cancer Center, The Ohio State UniversityThe Comprehensive Cancer Center, The Ohio State UniversityThe Comprehensive Cancer Center, The Ohio State UniversityThe Comprehensive Cancer Center, The Ohio State UniversityDepartment of Biomedical Informatics’ Center for Biostatistics, The Ohio State UniversityDepartment of Biomedical Informatics’ Center for Biostatistics, The Ohio State UniversityThe Comprehensive Cancer Center, The Ohio State UniversityThe Comprehensive Cancer Center, The Ohio State UniversityThe Comprehensive Cancer Center, The Ohio State UniversityDivision of Surgical Oncology, Department of Surgery, City of HopeDepartment of Molecular and Cellular Biology, College of Arts and Sciences, Ohio UniversityThe Comprehensive Cancer Center, The Ohio State UniversityRosalind and Morris Goodman Cancer Research Centre, McGill UniversityHollings Cancer Center, Medical University of South CarolinaHollings Cancer Center, Medical University of South CarolinaThe tumor microenvironment influences tumor progression. Here the authors show that lack of stromal PTEN phosphatase induces DNA repair defects in the neighboring mammary gland epithelial cells via hyperactivation of EGF-receptor signaling, resulting in higher radiation-induced DNA damage and hyperplasia.https://doi.org/10.1038/s41467-018-05266-6 |
| spellingShingle | Gina M. Sizemore Subhasree Balakrishnan Katie A. Thies Anisha M. Hammer Steven T. Sizemore Anthony J. Trimboli Maria C. Cuitiño Sarah A. Steck Gary Tozbikian Raleigh D. Kladney Neelam Shinde Manjusri Das Dongju Park Sarmila Majumder Shiva Krishnan Lianbo Yu Soledad A. Fernandez Arnab Chakravarti Peter G. Shields Julia R. White Lisa D. Yee Thomas J. Rosol Thomas Ludwig Morag Park Gustavo Leone Michael C. Ostrowski Stromal PTEN determines mammary epithelial response to radiotherapy Nature Communications |
| title | Stromal PTEN determines mammary epithelial response to radiotherapy |
| title_full | Stromal PTEN determines mammary epithelial response to radiotherapy |
| title_fullStr | Stromal PTEN determines mammary epithelial response to radiotherapy |
| title_full_unstemmed | Stromal PTEN determines mammary epithelial response to radiotherapy |
| title_short | Stromal PTEN determines mammary epithelial response to radiotherapy |
| title_sort | stromal pten determines mammary epithelial response to radiotherapy |
| url | https://doi.org/10.1038/s41467-018-05266-6 |
| work_keys_str_mv | AT ginamsizemore stromalptendeterminesmammaryepithelialresponsetoradiotherapy AT subhasreebalakrishnan stromalptendeterminesmammaryepithelialresponsetoradiotherapy AT katieathies stromalptendeterminesmammaryepithelialresponsetoradiotherapy AT anishamhammer stromalptendeterminesmammaryepithelialresponsetoradiotherapy AT steventsizemore stromalptendeterminesmammaryepithelialresponsetoradiotherapy AT anthonyjtrimboli stromalptendeterminesmammaryepithelialresponsetoradiotherapy AT mariaccuitino stromalptendeterminesmammaryepithelialresponsetoradiotherapy AT sarahasteck stromalptendeterminesmammaryepithelialresponsetoradiotherapy AT garytozbikian stromalptendeterminesmammaryepithelialresponsetoradiotherapy AT raleighdkladney stromalptendeterminesmammaryepithelialresponsetoradiotherapy AT neelamshinde stromalptendeterminesmammaryepithelialresponsetoradiotherapy AT manjusridas stromalptendeterminesmammaryepithelialresponsetoradiotherapy AT dongjupark stromalptendeterminesmammaryepithelialresponsetoradiotherapy AT sarmilamajumder stromalptendeterminesmammaryepithelialresponsetoradiotherapy AT shivakrishnan stromalptendeterminesmammaryepithelialresponsetoradiotherapy AT lianboyu stromalptendeterminesmammaryepithelialresponsetoradiotherapy AT soledadafernandez stromalptendeterminesmammaryepithelialresponsetoradiotherapy AT arnabchakravarti stromalptendeterminesmammaryepithelialresponsetoradiotherapy AT petergshields stromalptendeterminesmammaryepithelialresponsetoradiotherapy AT juliarwhite stromalptendeterminesmammaryepithelialresponsetoradiotherapy AT lisadyee stromalptendeterminesmammaryepithelialresponsetoradiotherapy AT thomasjrosol stromalptendeterminesmammaryepithelialresponsetoradiotherapy AT thomasludwig stromalptendeterminesmammaryepithelialresponsetoradiotherapy AT moragpark stromalptendeterminesmammaryepithelialresponsetoradiotherapy AT gustavoleone stromalptendeterminesmammaryepithelialresponsetoradiotherapy AT michaelcostrowski stromalptendeterminesmammaryepithelialresponsetoradiotherapy |