Comparison of the Prognostic Value of Ki-67 and Programmed Cell Death Ligand-1 in Patients with Upper Tract Urothelial Carcinoma
We retrospectively enrolled 102 patients with upper tract urothelial carcinoma (UTUC) who underwent radical nephroureterectomy to examine the prognostic value of Ki-67 and programmed cell death ligand-1 (PD-L1). Then, we performed PD-L1 and Ki-67 immunohistochemical staining on whole tissue sections...
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2021-08-01
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| author | Mu-Yao Tsai Ping-Chia Chiang Chien-Hsu Chen Ming-Tse Sung Shun-Chen Huang Jau-Ling Suen Eing-Mei Tsai Po-Hui Chiang |
| author_facet | Mu-Yao Tsai Ping-Chia Chiang Chien-Hsu Chen Ming-Tse Sung Shun-Chen Huang Jau-Ling Suen Eing-Mei Tsai Po-Hui Chiang |
| author_sort | Mu-Yao Tsai |
| collection | DOAJ |
| description | We retrospectively enrolled 102 patients with upper tract urothelial carcinoma (UTUC) who underwent radical nephroureterectomy to examine the prognostic value of Ki-67 and programmed cell death ligand-1 (PD-L1). Then, we performed PD-L1 and Ki-67 immunohistochemical staining on whole tissue sections. The cut-off value of PD-L1 positivity was a combined positive score (CPS) ≥10 and the Ki-67 overexpression was 20%. Among the 102 patients, 16.7% and 48.0% showed positive PD-L1 expression and Ki-67 overexpression, respectively. A CPS ≥10 was significantly associated with a higher pathological T stage (<i>p</i> = 0.049). In addition, Ki-67 overexpression was significantly associated with a pathological T stage ≥ 2 (<i>p</i> = 0.027) and tumour necrosis (<i>p</i> = 0.016). In the multivariable analysis, a positive PD-L1 expression was significantly correlated with worse cancer-specific survival (HR = 3.66, 95% CI =1.37−9.77, <i>p</i> = 0.01). However, there was no predictive value using a combination of PD-L1 expression and Ki-67 overexpression as a prognostic predictor. Compared with Ki-67 overexpression, a positive PD-L1 expression with CPS ≥ 10 was a stronger independent prognostic factor for CSS in patients with UTUC. |
| first_indexed | 2024-03-10T08:42:28Z |
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| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T08:42:28Z |
| publishDate | 2021-08-01 |
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| series | Journal of Clinical Medicine |
| spelling | doaj.art-f411bcf9f5b4402fb855ea5bce41bd642023-11-22T08:12:41ZengMDPI AGJournal of Clinical Medicine2077-03832021-08-011016372810.3390/jcm10163728Comparison of the Prognostic Value of Ki-67 and Programmed Cell Death Ligand-1 in Patients with Upper Tract Urothelial CarcinomaMu-Yao Tsai0Ping-Chia Chiang1Chien-Hsu Chen2Ming-Tse Sung3Shun-Chen Huang4Jau-Ling Suen5Eing-Mei Tsai6Po-Hui Chiang7Department of Urology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 83301, TaiwanDepartment of Urology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 83301, TaiwanDepartment of Urology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 83301, TaiwanDepartment of Anatomic Pathology, Kaohsiung Chang Gung Memorial Hospitale, Chang Gung Univerity College of Medicine, Kaohsiung 83301, TaiwanDepartment of Anatomic Pathology, Kaohsiung Chang Gung Memorial Hospitale, Chang Gung Univerity College of Medicine, Kaohsiung 83301, TaiwanGraduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, TaiwanGraduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, TaiwanDepartment of Urology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 83301, TaiwanWe retrospectively enrolled 102 patients with upper tract urothelial carcinoma (UTUC) who underwent radical nephroureterectomy to examine the prognostic value of Ki-67 and programmed cell death ligand-1 (PD-L1). Then, we performed PD-L1 and Ki-67 immunohistochemical staining on whole tissue sections. The cut-off value of PD-L1 positivity was a combined positive score (CPS) ≥10 and the Ki-67 overexpression was 20%. Among the 102 patients, 16.7% and 48.0% showed positive PD-L1 expression and Ki-67 overexpression, respectively. A CPS ≥10 was significantly associated with a higher pathological T stage (<i>p</i> = 0.049). In addition, Ki-67 overexpression was significantly associated with a pathological T stage ≥ 2 (<i>p</i> = 0.027) and tumour necrosis (<i>p</i> = 0.016). In the multivariable analysis, a positive PD-L1 expression was significantly correlated with worse cancer-specific survival (HR = 3.66, 95% CI =1.37−9.77, <i>p</i> = 0.01). However, there was no predictive value using a combination of PD-L1 expression and Ki-67 overexpression as a prognostic predictor. Compared with Ki-67 overexpression, a positive PD-L1 expression with CPS ≥ 10 was a stronger independent prognostic factor for CSS in patients with UTUC.https://www.mdpi.com/2077-0383/10/16/3728combined positive scoreKi-67programmed cell death ligand-1radical nephroureterectomyupper tract urothelial carcinoma |
| spellingShingle | Mu-Yao Tsai Ping-Chia Chiang Chien-Hsu Chen Ming-Tse Sung Shun-Chen Huang Jau-Ling Suen Eing-Mei Tsai Po-Hui Chiang Comparison of the Prognostic Value of Ki-67 and Programmed Cell Death Ligand-1 in Patients with Upper Tract Urothelial Carcinoma Journal of Clinical Medicine combined positive score Ki-67 programmed cell death ligand-1 radical nephroureterectomy upper tract urothelial carcinoma |
| title | Comparison of the Prognostic Value of Ki-67 and Programmed Cell Death Ligand-1 in Patients with Upper Tract Urothelial Carcinoma |
| title_full | Comparison of the Prognostic Value of Ki-67 and Programmed Cell Death Ligand-1 in Patients with Upper Tract Urothelial Carcinoma |
| title_fullStr | Comparison of the Prognostic Value of Ki-67 and Programmed Cell Death Ligand-1 in Patients with Upper Tract Urothelial Carcinoma |
| title_full_unstemmed | Comparison of the Prognostic Value of Ki-67 and Programmed Cell Death Ligand-1 in Patients with Upper Tract Urothelial Carcinoma |
| title_short | Comparison of the Prognostic Value of Ki-67 and Programmed Cell Death Ligand-1 in Patients with Upper Tract Urothelial Carcinoma |
| title_sort | comparison of the prognostic value of ki 67 and programmed cell death ligand 1 in patients with upper tract urothelial carcinoma |
| topic | combined positive score Ki-67 programmed cell death ligand-1 radical nephroureterectomy upper tract urothelial carcinoma |
| url | https://www.mdpi.com/2077-0383/10/16/3728 |
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