FDG-PET/CT imaging parameters for predicting spontaneous regression of methotrexate-associated lymphoproliferative disorder in patients with rheumatoid arthritis
Abstract In this study, we investigated the usefulness of FDG-PET/CT for predicting spontaneous regression in methotrexate-associated lymphoproliferative disorder (MTX-LPD). Twenty patients with rheumatoid arthritis who were diagnosed with MTX-LPD were enrolled in the study. These patients were divi...
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| Format: | Article |
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Nature Portfolio
2022-09-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-19727-y |
| _version_ | 1811267349588738048 |
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| author | Tomohiro Kameda Shusaku Nakashima Katsuya Mitamura Yuka Yamamoto Takashi Norikane Hiromi Shimada Risa Wakiya Mikiya Kato Taichi Miyagi Koichi Sugihara Rina Mino Mao Mizusaki Norimitsu Kadowaki Hiroaki Dobashi |
| author_facet | Tomohiro Kameda Shusaku Nakashima Katsuya Mitamura Yuka Yamamoto Takashi Norikane Hiromi Shimada Risa Wakiya Mikiya Kato Taichi Miyagi Koichi Sugihara Rina Mino Mao Mizusaki Norimitsu Kadowaki Hiroaki Dobashi |
| author_sort | Tomohiro Kameda |
| collection | DOAJ |
| description | Abstract In this study, we investigated the usefulness of FDG-PET/CT for predicting spontaneous regression in methotrexate-associated lymphoproliferative disorder (MTX-LPD). Twenty patients with rheumatoid arthritis who were diagnosed with MTX-LPD were enrolled in the study. These patients were divided into those who showed spontaneous regression (SR group: ten patients) and those who received chemotherapy after discontinuation of MTX (CTx group: ten patients). Between-group differences in potential biomarkers were compared, including clinical markers at the onset of LPD [serum LDH and interleukin 2 receptor (sIL-2R)], change in absolute number of peripheral lymphocytes (ΔALC) over follow-up, and the FDG-PET/CT-derived parameters of maximum standardized uptake value (SUVmax), mean SUV (SUVmean), peak SUV (SUVpeak), sum of the metabolic tumor volume (MTVsum), and sum of total lesion glycolysis (TLGsum). The levels of sIL-2R, MTVsum, and TLGsum were significantly lower in the SR group than in the CTx group. In addition, ΔALC was higher in the SR group. In conclusion, MTV and TLG values measured by FDG-PET/CT may be suitable for use as predictors of SR in patients with MTX-LPD. |
| first_indexed | 2024-04-12T21:00:54Z |
| format | Article |
| id | doaj.art-f412e24edab84f03bab99bf73815b147 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-12T21:00:54Z |
| publishDate | 2022-09-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj.art-f412e24edab84f03bab99bf73815b1472022-12-22T03:16:51ZengNature PortfolioScientific Reports2045-23222022-09-011211710.1038/s41598-022-19727-yFDG-PET/CT imaging parameters for predicting spontaneous regression of methotrexate-associated lymphoproliferative disorder in patients with rheumatoid arthritisTomohiro Kameda0Shusaku Nakashima1Katsuya Mitamura2Yuka Yamamoto3Takashi Norikane4Hiromi Shimada5Risa Wakiya6Mikiya Kato7Taichi Miyagi8Koichi Sugihara9Rina Mino10Mao Mizusaki11Norimitsu Kadowaki12Hiroaki Dobashi13Department of Internal Medicine, Division of Hematology, Rheumatology and Respiratory Medicine, Faculty of Medicine, Kagawa UniversityDepartment of Internal Medicine, Division of Hematology, Rheumatology and Respiratory Medicine, Faculty of Medicine, Kagawa UniversityDepartment of Radiology, Faculty of Medicine, Kagawa UniversityDepartment of Radiology, Faculty of Medicine, Kagawa UniversityDepartment of Radiology, Faculty of Medicine, Kagawa UniversityDepartment of Internal Medicine, Division of Hematology, Rheumatology and Respiratory Medicine, Faculty of Medicine, Kagawa UniversityDepartment of Internal Medicine, Division of Hematology, Rheumatology and Respiratory Medicine, Faculty of Medicine, Kagawa UniversityDepartment of Internal Medicine, Division of Hematology, Rheumatology and Respiratory Medicine, Faculty of Medicine, Kagawa UniversityDepartment of Internal Medicine, Division of Hematology, Rheumatology and Respiratory Medicine, Faculty of Medicine, Kagawa UniversityDepartment of Internal Medicine, Division of Hematology, Rheumatology and Respiratory Medicine, Faculty of Medicine, Kagawa UniversityDepartment of Internal Medicine, Division of Hematology, Rheumatology and Respiratory Medicine, Faculty of Medicine, Kagawa UniversityDepartment of Internal Medicine, Division of Hematology, Rheumatology and Respiratory Medicine, Faculty of Medicine, Kagawa UniversityDepartment of Internal Medicine, Division of Hematology, Rheumatology and Respiratory Medicine, Faculty of Medicine, Kagawa UniversityDepartment of Internal Medicine, Division of Hematology, Rheumatology and Respiratory Medicine, Faculty of Medicine, Kagawa UniversityAbstract In this study, we investigated the usefulness of FDG-PET/CT for predicting spontaneous regression in methotrexate-associated lymphoproliferative disorder (MTX-LPD). Twenty patients with rheumatoid arthritis who were diagnosed with MTX-LPD were enrolled in the study. These patients were divided into those who showed spontaneous regression (SR group: ten patients) and those who received chemotherapy after discontinuation of MTX (CTx group: ten patients). Between-group differences in potential biomarkers were compared, including clinical markers at the onset of LPD [serum LDH and interleukin 2 receptor (sIL-2R)], change in absolute number of peripheral lymphocytes (ΔALC) over follow-up, and the FDG-PET/CT-derived parameters of maximum standardized uptake value (SUVmax), mean SUV (SUVmean), peak SUV (SUVpeak), sum of the metabolic tumor volume (MTVsum), and sum of total lesion glycolysis (TLGsum). The levels of sIL-2R, MTVsum, and TLGsum were significantly lower in the SR group than in the CTx group. In addition, ΔALC was higher in the SR group. In conclusion, MTV and TLG values measured by FDG-PET/CT may be suitable for use as predictors of SR in patients with MTX-LPD.https://doi.org/10.1038/s41598-022-19727-y |
| spellingShingle | Tomohiro Kameda Shusaku Nakashima Katsuya Mitamura Yuka Yamamoto Takashi Norikane Hiromi Shimada Risa Wakiya Mikiya Kato Taichi Miyagi Koichi Sugihara Rina Mino Mao Mizusaki Norimitsu Kadowaki Hiroaki Dobashi FDG-PET/CT imaging parameters for predicting spontaneous regression of methotrexate-associated lymphoproliferative disorder in patients with rheumatoid arthritis Scientific Reports |
| title | FDG-PET/CT imaging parameters for predicting spontaneous regression of methotrexate-associated lymphoproliferative disorder in patients with rheumatoid arthritis |
| title_full | FDG-PET/CT imaging parameters for predicting spontaneous regression of methotrexate-associated lymphoproliferative disorder in patients with rheumatoid arthritis |
| title_fullStr | FDG-PET/CT imaging parameters for predicting spontaneous regression of methotrexate-associated lymphoproliferative disorder in patients with rheumatoid arthritis |
| title_full_unstemmed | FDG-PET/CT imaging parameters for predicting spontaneous regression of methotrexate-associated lymphoproliferative disorder in patients with rheumatoid arthritis |
| title_short | FDG-PET/CT imaging parameters for predicting spontaneous regression of methotrexate-associated lymphoproliferative disorder in patients with rheumatoid arthritis |
| title_sort | fdg pet ct imaging parameters for predicting spontaneous regression of methotrexate associated lymphoproliferative disorder in patients with rheumatoid arthritis |
| url | https://doi.org/10.1038/s41598-022-19727-y |
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