Demyelinating CNS processes in late post-liver transplant period
In solid organ recipients, post-transplant neurotoxicity of calcineurin inhibitors (CIs) can be manifested by brain and spinal cord demyelination with multiple sclerosis (MS)-like symptoms. Here are presented two case reports of neurological MS-like symptoms in the long-term post-liver transplant...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Research Center of Neurology
2023-09-01
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| Series: | Анналы клинической и экспериментальной неврологии |
| Subjects: | |
| Online Access: | https://annaly-nevrologii.com/journal/pathID/article/viewFile/878/pdf |
| _version_ | 1797261541588860928 |
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| author | Anastasia A. Salienko Vladimir E. Syutkin Maria V. Lisitskaya Denis V. Kuznetsov Murad S. Novruzbekov |
| author_facet | Anastasia A. Salienko Vladimir E. Syutkin Maria V. Lisitskaya Denis V. Kuznetsov Murad S. Novruzbekov |
| author_sort | Anastasia A. Salienko |
| collection | DOAJ |
| description | In solid organ recipients, post-transplant neurotoxicity of calcineurin inhibitors (CIs) can be manifested by brain and spinal cord demyelination with multiple sclerosis (MS)-like symptoms.
Here are presented two case reports of neurological MS-like symptoms in the long-term post-liver transplant period with different underlying causes.
CI neurotoxicity may resemble various neurological diseases, including MS. At the same time, liver transplant recipients can develop true MS regardless of the immunosuppressant use. In liver transplant recipients, adequate differential diagnosis of neurological complications avoids unnecessary medications and reverses severe neurological deficits by immunosuppressant conversion. |
| first_indexed | 2024-04-24T23:42:52Z |
| format | Article |
| id | doaj.art-f4134bc032904d009f615bace4195f5f |
| institution | Directory Open Access Journal |
| issn | 2075-5473 2409-2533 |
| language | English |
| last_indexed | 2024-04-24T23:42:52Z |
| publishDate | 2023-09-01 |
| publisher | Research Center of Neurology |
| record_format | Article |
| series | Анналы клинической и экспериментальной неврологии |
| spelling | doaj.art-f4134bc032904d009f615bace4195f5f2024-03-15T10:29:53ZengResearch Center of NeurologyАнналы клинической и экспериментальной неврологии2075-54732409-25332023-09-01173838710.54101/ACEN.2023.3.10653Demyelinating CNS processes in late post-liver transplant periodAnastasia A. Salienko0https://orcid.org/0000-0002-2732-684XVladimir E. Syutkin1https://orcid.org/0000-0001-8391-5211Maria V. Lisitskaya2https://orcid.org/0000-0002-8402-7643Denis V. Kuznetsov3https://orcid.org/0000-0002-8201-2376Murad S. Novruzbekov4https://orcid.org/0000-0002-6362-7914Sklifosovsky Research Institute for Emergency MedicineSklifosovsky Research Institute for Emergency MedicineLomonosov Moscow State UniversityMoscow Scientific and Practical Center of Dermatology, Venerology and CosmetologySklifosovsky Research Institute for Emergency MedicineIn solid organ recipients, post-transplant neurotoxicity of calcineurin inhibitors (CIs) can be manifested by brain and spinal cord demyelination with multiple sclerosis (MS)-like symptoms. Here are presented two case reports of neurological MS-like symptoms in the long-term post-liver transplant period with different underlying causes. CI neurotoxicity may resemble various neurological diseases, including MS. At the same time, liver transplant recipients can develop true MS regardless of the immunosuppressant use. In liver transplant recipients, adequate differential diagnosis of neurological complications avoids unnecessary medications and reverses severe neurological deficits by immunosuppressant conversion.https://annaly-nevrologii.com/journal/pathID/article/viewFile/878/pdfliver transplantcalcineurin inhibitorsneurotoxicitymultiple sclerosiseverolimus |
| spellingShingle | Anastasia A. Salienko Vladimir E. Syutkin Maria V. Lisitskaya Denis V. Kuznetsov Murad S. Novruzbekov Demyelinating CNS processes in late post-liver transplant period Анналы клинической и экспериментальной неврологии liver transplant calcineurin inhibitors neurotoxicity multiple sclerosis everolimus |
| title | Demyelinating CNS processes in late post-liver transplant period |
| title_full | Demyelinating CNS processes in late post-liver transplant period |
| title_fullStr | Demyelinating CNS processes in late post-liver transplant period |
| title_full_unstemmed | Demyelinating CNS processes in late post-liver transplant period |
| title_short | Demyelinating CNS processes in late post-liver transplant period |
| title_sort | demyelinating cns processes in late post liver transplant period |
| topic | liver transplant calcineurin inhibitors neurotoxicity multiple sclerosis everolimus |
| url | https://annaly-nevrologii.com/journal/pathID/article/viewFile/878/pdf |
| work_keys_str_mv | AT anastasiaasalienko demyelinatingcnsprocessesinlatepostlivertransplantperiod AT vladimiresyutkin demyelinatingcnsprocessesinlatepostlivertransplantperiod AT mariavlisitskaya demyelinatingcnsprocessesinlatepostlivertransplantperiod AT denisvkuznetsov demyelinatingcnsprocessesinlatepostlivertransplantperiod AT muradsnovruzbekov demyelinatingcnsprocessesinlatepostlivertransplantperiod |