Emergence of Streptococcus pneumoniae serotype 19A (Spn19A) in the pediatric population in Bogotá, Colombia as the main cause of invasive pneumococcal disease after the introduction of PCV10
Introduction: With the use of pneumococcal conjugate vaccines(PCV), the behavior of invasive pneumococcal disease(IPD) has changed relative to serotype distribution. The introduction of these vaccines in national immunization programs has reduced the incidence of IPD, with a marked decrease in the c...
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Taylor & Francis Group
2020-09-01
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Series: | Human Vaccines & Immunotherapeutics |
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Online Access: | http://dx.doi.org/10.1080/21645515.2019.1710411 |
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author | Germán Camacho Moreno Luisa F. Imbachi Aura L. Leal Vivian M. Moreno Jaime A. Patiño Iván F. Gutiérrez Sandra Beltrán Martha I. Álvarez-Olmos Cristina Mariño Rocío Barrero Fabio Espinosa Nicolás Ramos Liliana P. Castellar Nella Sánchez Anita Montañez |
author_facet | Germán Camacho Moreno Luisa F. Imbachi Aura L. Leal Vivian M. Moreno Jaime A. Patiño Iván F. Gutiérrez Sandra Beltrán Martha I. Álvarez-Olmos Cristina Mariño Rocío Barrero Fabio Espinosa Nicolás Ramos Liliana P. Castellar Nella Sánchez Anita Montañez |
author_sort | Germán Camacho Moreno |
collection | DOAJ |
description | Introduction: With the use of pneumococcal conjugate vaccines(PCV), the behavior of invasive pneumococcal disease(IPD) has changed relative to serotype distribution. The introduction of these vaccines in national immunization programs has reduced the incidence of IPD, with a marked decrease in the circulation of the serotypes included in the vaccine used in each country. However, the subsequent emergence of other serotypes not included in the vaccine, such 19A in case of PCV7 and PCV10, has been documented. Materials and methods: This was case series study (2008–2017) in pediatric patients admitted to 10 hospitals in Bogota who were diagnosed with IPD. It was conducted during the transitional period of implementing the PCV10 vaccine in Colombia in 2012. Cases of bacteremic pneumococcal pneumonia, meningitis, primary bacteremia and osteoarticular infection were included. A descriptive analysis of the demographic, clinical and laboratory variables of patients with IPD by Spn19A, its trend over time, profiles of antimicrobial susceptibility and clinical outcomes was performed. Results: There were 463 cases of IPD, 315(68%) with known serotypes. The prevalence of IPD by Spn19A was 17.7%(56 cases), tending to increase over time. During 2008–2011, the prevalence was 4.4%, and during 2014–2017, it was 32.4%, The most frequent diagnosis was pneumonia(80.4%). In nonmeningeal isolates, 39.6% were not susceptible to penicillin. An increase in the resistance was observed over time. Conclusion: Spn19A is a prevalent cause of IPD in the pediatric population of the analyzed cohort, with an increasing trend of this serotype during the surveillance period after the introduction of PCV10, being the most common serotype identified in recent years. |
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language | English |
last_indexed | 2024-03-11T22:43:19Z |
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spelling | doaj.art-f413edfc87a943d081cb2362a8d4aaa82023-09-22T08:45:35ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2020-09-011692300230610.1080/21645515.2019.17104111710411Emergence of Streptococcus pneumoniae serotype 19A (Spn19A) in the pediatric population in Bogotá, Colombia as the main cause of invasive pneumococcal disease after the introduction of PCV10Germán Camacho Moreno0Luisa F. Imbachi1Aura L. Leal2Vivian M. Moreno3Jaime A. Patiño4Iván F. Gutiérrez5Sandra Beltrán6Martha I. Álvarez-Olmos7Cristina Mariño8Rocío Barrero9Fabio Espinosa10Nicolás Ramos11Liliana P. Castellar12Nella Sánchez13Anita Montañez14Universidad Nacional de ColombiaUniversidad Nacional de ColombiaUniversidad Nacional de ColombiaRed NeumocolombiaRed NeumocolombiaRed NeumocolombiaRed NeumocolombiaRed NeumocolombiaRed NeumocolombiaRed NeumocolombiaRed NeumocolombiaRed NeumocolombiaFundación HOMI – Hospital Pediátrico de la MisericordiaRed NeumocolombiaUniversidad Nacional de ColombiaIntroduction: With the use of pneumococcal conjugate vaccines(PCV), the behavior of invasive pneumococcal disease(IPD) has changed relative to serotype distribution. The introduction of these vaccines in national immunization programs has reduced the incidence of IPD, with a marked decrease in the circulation of the serotypes included in the vaccine used in each country. However, the subsequent emergence of other serotypes not included in the vaccine, such 19A in case of PCV7 and PCV10, has been documented. Materials and methods: This was case series study (2008–2017) in pediatric patients admitted to 10 hospitals in Bogota who were diagnosed with IPD. It was conducted during the transitional period of implementing the PCV10 vaccine in Colombia in 2012. Cases of bacteremic pneumococcal pneumonia, meningitis, primary bacteremia and osteoarticular infection were included. A descriptive analysis of the demographic, clinical and laboratory variables of patients with IPD by Spn19A, its trend over time, profiles of antimicrobial susceptibility and clinical outcomes was performed. Results: There were 463 cases of IPD, 315(68%) with known serotypes. The prevalence of IPD by Spn19A was 17.7%(56 cases), tending to increase over time. During 2008–2011, the prevalence was 4.4%, and during 2014–2017, it was 32.4%, The most frequent diagnosis was pneumonia(80.4%). In nonmeningeal isolates, 39.6% were not susceptible to penicillin. An increase in the resistance was observed over time. Conclusion: Spn19A is a prevalent cause of IPD in the pediatric population of the analyzed cohort, with an increasing trend of this serotype during the surveillance period after the introduction of PCV10, being the most common serotype identified in recent years.http://dx.doi.org/10.1080/21645515.2019.1710411pneumococcal infectionsstreptococcus pneumoniaepneumococcal vaccinesepidemiologyserotype 19a |
spellingShingle | Germán Camacho Moreno Luisa F. Imbachi Aura L. Leal Vivian M. Moreno Jaime A. Patiño Iván F. Gutiérrez Sandra Beltrán Martha I. Álvarez-Olmos Cristina Mariño Rocío Barrero Fabio Espinosa Nicolás Ramos Liliana P. Castellar Nella Sánchez Anita Montañez Emergence of Streptococcus pneumoniae serotype 19A (Spn19A) in the pediatric population in Bogotá, Colombia as the main cause of invasive pneumococcal disease after the introduction of PCV10 Human Vaccines & Immunotherapeutics pneumococcal infections streptococcus pneumoniae pneumococcal vaccines epidemiology serotype 19a |
title | Emergence of Streptococcus pneumoniae serotype 19A (Spn19A) in the pediatric population in Bogotá, Colombia as the main cause of invasive pneumococcal disease after the introduction of PCV10 |
title_full | Emergence of Streptococcus pneumoniae serotype 19A (Spn19A) in the pediatric population in Bogotá, Colombia as the main cause of invasive pneumococcal disease after the introduction of PCV10 |
title_fullStr | Emergence of Streptococcus pneumoniae serotype 19A (Spn19A) in the pediatric population in Bogotá, Colombia as the main cause of invasive pneumococcal disease after the introduction of PCV10 |
title_full_unstemmed | Emergence of Streptococcus pneumoniae serotype 19A (Spn19A) in the pediatric population in Bogotá, Colombia as the main cause of invasive pneumococcal disease after the introduction of PCV10 |
title_short | Emergence of Streptococcus pneumoniae serotype 19A (Spn19A) in the pediatric population in Bogotá, Colombia as the main cause of invasive pneumococcal disease after the introduction of PCV10 |
title_sort | emergence of streptococcus pneumoniae serotype 19a spn19a in the pediatric population in bogota colombia as the main cause of invasive pneumococcal disease after the introduction of pcv10 |
topic | pneumococcal infections streptococcus pneumoniae pneumococcal vaccines epidemiology serotype 19a |
url | http://dx.doi.org/10.1080/21645515.2019.1710411 |
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