Emergence of Streptococcus pneumoniae serotype 19A (Spn19A) in the pediatric population in Bogotá, Colombia as the main cause of invasive pneumococcal disease after the introduction of PCV10

Introduction: With the use of pneumococcal conjugate vaccines(PCV), the behavior of invasive pneumococcal disease(IPD) has changed relative to serotype distribution. The introduction of these vaccines in national immunization programs has reduced the incidence of IPD, with a marked decrease in the c...

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Main Authors: Germán Camacho Moreno, Luisa F. Imbachi, Aura L. Leal, Vivian M. Moreno, Jaime A. Patiño, Iván F. Gutiérrez, Sandra Beltrán, Martha I. Álvarez-Olmos, Cristina Mariño, Rocío Barrero, Fabio Espinosa, Nicolás Ramos, Liliana P. Castellar, Nella Sánchez, Anita Montañez
Format: Article
Language:English
Published: Taylor & Francis Group 2020-09-01
Series:Human Vaccines & Immunotherapeutics
Subjects:
Online Access:http://dx.doi.org/10.1080/21645515.2019.1710411
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author Germán Camacho Moreno
Luisa F. Imbachi
Aura L. Leal
Vivian M. Moreno
Jaime A. Patiño
Iván F. Gutiérrez
Sandra Beltrán
Martha I. Álvarez-Olmos
Cristina Mariño
Rocío Barrero
Fabio Espinosa
Nicolás Ramos
Liliana P. Castellar
Nella Sánchez
Anita Montañez
author_facet Germán Camacho Moreno
Luisa F. Imbachi
Aura L. Leal
Vivian M. Moreno
Jaime A. Patiño
Iván F. Gutiérrez
Sandra Beltrán
Martha I. Álvarez-Olmos
Cristina Mariño
Rocío Barrero
Fabio Espinosa
Nicolás Ramos
Liliana P. Castellar
Nella Sánchez
Anita Montañez
author_sort Germán Camacho Moreno
collection DOAJ
description Introduction: With the use of pneumococcal conjugate vaccines(PCV), the behavior of invasive pneumococcal disease(IPD) has changed relative to serotype distribution. The introduction of these vaccines in national immunization programs has reduced the incidence of IPD, with a marked decrease in the circulation of the serotypes included in the vaccine used in each country. However, the subsequent emergence of other serotypes not included in the vaccine, such 19A in case of PCV7 and PCV10, has been documented. Materials and methods: This was case series study (2008–2017) in pediatric patients admitted to 10 hospitals in Bogota who were diagnosed with IPD. It was conducted during the transitional period of implementing the PCV10 vaccine in Colombia in 2012. Cases of bacteremic pneumococcal pneumonia, meningitis, primary bacteremia and osteoarticular infection were included. A descriptive analysis of the demographic, clinical and laboratory variables of patients with IPD by Spn19A, its trend over time, profiles of antimicrobial susceptibility and clinical outcomes was performed. Results: There were 463 cases of IPD, 315(68%) with known serotypes. The prevalence of IPD by Spn19A was 17.7%(56 cases), tending to increase over time. During 2008–2011, the prevalence was 4.4%, and during 2014–2017, it was 32.4%, The most frequent diagnosis was pneumonia(80.4%). In nonmeningeal isolates, 39.6% were not susceptible to penicillin. An increase in the resistance was observed over time. Conclusion: Spn19A is a prevalent cause of IPD in the pediatric population of the analyzed cohort, with an increasing trend of this serotype during the surveillance period after the introduction of PCV10, being the most common serotype identified in recent years.
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spelling doaj.art-f413edfc87a943d081cb2362a8d4aaa82023-09-22T08:45:35ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2020-09-011692300230610.1080/21645515.2019.17104111710411Emergence of Streptococcus pneumoniae serotype 19A (Spn19A) in the pediatric population in Bogotá, Colombia as the main cause of invasive pneumococcal disease after the introduction of PCV10Germán Camacho Moreno0Luisa F. Imbachi1Aura L. Leal2Vivian M. Moreno3Jaime A. Patiño4Iván F. Gutiérrez5Sandra Beltrán6Martha I. Álvarez-Olmos7Cristina Mariño8Rocío Barrero9Fabio Espinosa10Nicolás Ramos11Liliana P. Castellar12Nella Sánchez13Anita Montañez14Universidad Nacional de ColombiaUniversidad Nacional de ColombiaUniversidad Nacional de ColombiaRed NeumocolombiaRed NeumocolombiaRed NeumocolombiaRed NeumocolombiaRed NeumocolombiaRed NeumocolombiaRed NeumocolombiaRed NeumocolombiaRed NeumocolombiaFundación HOMI – Hospital Pediátrico de la MisericordiaRed NeumocolombiaUniversidad Nacional de ColombiaIntroduction: With the use of pneumococcal conjugate vaccines(PCV), the behavior of invasive pneumococcal disease(IPD) has changed relative to serotype distribution. The introduction of these vaccines in national immunization programs has reduced the incidence of IPD, with a marked decrease in the circulation of the serotypes included in the vaccine used in each country. However, the subsequent emergence of other serotypes not included in the vaccine, such 19A in case of PCV7 and PCV10, has been documented. Materials and methods: This was case series study (2008–2017) in pediatric patients admitted to 10 hospitals in Bogota who were diagnosed with IPD. It was conducted during the transitional period of implementing the PCV10 vaccine in Colombia in 2012. Cases of bacteremic pneumococcal pneumonia, meningitis, primary bacteremia and osteoarticular infection were included. A descriptive analysis of the demographic, clinical and laboratory variables of patients with IPD by Spn19A, its trend over time, profiles of antimicrobial susceptibility and clinical outcomes was performed. Results: There were 463 cases of IPD, 315(68%) with known serotypes. The prevalence of IPD by Spn19A was 17.7%(56 cases), tending to increase over time. During 2008–2011, the prevalence was 4.4%, and during 2014–2017, it was 32.4%, The most frequent diagnosis was pneumonia(80.4%). In nonmeningeal isolates, 39.6% were not susceptible to penicillin. An increase in the resistance was observed over time. Conclusion: Spn19A is a prevalent cause of IPD in the pediatric population of the analyzed cohort, with an increasing trend of this serotype during the surveillance period after the introduction of PCV10, being the most common serotype identified in recent years.http://dx.doi.org/10.1080/21645515.2019.1710411pneumococcal infectionsstreptococcus pneumoniaepneumococcal vaccinesepidemiologyserotype 19a
spellingShingle Germán Camacho Moreno
Luisa F. Imbachi
Aura L. Leal
Vivian M. Moreno
Jaime A. Patiño
Iván F. Gutiérrez
Sandra Beltrán
Martha I. Álvarez-Olmos
Cristina Mariño
Rocío Barrero
Fabio Espinosa
Nicolás Ramos
Liliana P. Castellar
Nella Sánchez
Anita Montañez
Emergence of Streptococcus pneumoniae serotype 19A (Spn19A) in the pediatric population in Bogotá, Colombia as the main cause of invasive pneumococcal disease after the introduction of PCV10
Human Vaccines & Immunotherapeutics
pneumococcal infections
streptococcus pneumoniae
pneumococcal vaccines
epidemiology
serotype 19a
title Emergence of Streptococcus pneumoniae serotype 19A (Spn19A) in the pediatric population in Bogotá, Colombia as the main cause of invasive pneumococcal disease after the introduction of PCV10
title_full Emergence of Streptococcus pneumoniae serotype 19A (Spn19A) in the pediatric population in Bogotá, Colombia as the main cause of invasive pneumococcal disease after the introduction of PCV10
title_fullStr Emergence of Streptococcus pneumoniae serotype 19A (Spn19A) in the pediatric population in Bogotá, Colombia as the main cause of invasive pneumococcal disease after the introduction of PCV10
title_full_unstemmed Emergence of Streptococcus pneumoniae serotype 19A (Spn19A) in the pediatric population in Bogotá, Colombia as the main cause of invasive pneumococcal disease after the introduction of PCV10
title_short Emergence of Streptococcus pneumoniae serotype 19A (Spn19A) in the pediatric population in Bogotá, Colombia as the main cause of invasive pneumococcal disease after the introduction of PCV10
title_sort emergence of streptococcus pneumoniae serotype 19a spn19a in the pediatric population in bogota colombia as the main cause of invasive pneumococcal disease after the introduction of pcv10
topic pneumococcal infections
streptococcus pneumoniae
pneumococcal vaccines
epidemiology
serotype 19a
url http://dx.doi.org/10.1080/21645515.2019.1710411
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