Exposure to medication for neurological disease in pregnancy – time to consider the long-term implications?
Summary: A range of long-term neurological conditions may be diagnosed in young adulthood. These conditions are generally not curable, and most people need to take ongoing treatment for symptom control and/or disease modification. When chronic diseases are diagnosed before people have completed thei...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-09-01
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| Series: | EClinicalMedicine |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589537023003346 |
| _version_ | 1797736854575906816 |
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| author | Chen Liu Samuel Pace Rebecca Bromley Ruth Dobson |
| author_facet | Chen Liu Samuel Pace Rebecca Bromley Ruth Dobson |
| author_sort | Chen Liu |
| collection | DOAJ |
| description | Summary: A range of long-term neurological conditions may be diagnosed in young adulthood. These conditions are generally not curable, and most people need to take ongoing treatment for symptom control and/or disease modification. When chronic diseases are diagnosed before people have completed their families, there is a need to balance the potential benefits of treatment for the mother against potential risk(s) to the fetus from exposure to medications during pregnancy. Whilst available data regarding short-term fetal outcomes following treatment exposures during pregnancy is rapidly increasing, information regarding longer-term outcomes is more limited. The association of fetal exposure to valproate with serious long-term neurodevelopmental outcomes has highlighted the importance of capturing and evaluating long-term data.In this review we examine available evidence around the long-term effects of treatments used for the most common long-term neurological conditions diagnosed in early adulthood, namely epilepsy, migraine and neuroinflammatory disorders. We draw from existing literature across a range of diseases and discuss strategies to improve future knowledge. |
| first_indexed | 2024-03-12T13:19:56Z |
| format | Article |
| id | doaj.art-f415fbcdda9646079843c1911eb33fbd |
| institution | Directory Open Access Journal |
| issn | 2589-5370 |
| language | English |
| last_indexed | 2024-03-12T13:19:56Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | EClinicalMedicine |
| spelling | doaj.art-f415fbcdda9646079843c1911eb33fbd2023-08-26T04:43:59ZengElsevierEClinicalMedicine2589-53702023-09-0163102157Exposure to medication for neurological disease in pregnancy – time to consider the long-term implications?Chen Liu0Samuel Pace1Rebecca Bromley2Ruth Dobson3Preventive Neurology Unit, Wolfson Institute of Population Health, QMUL, UKDepartment of Neurology, Royal London Hospital, Barts Health NHS Trust, London, UKDivision of Neuroscience, School of Biological Sciences, Faculty of Medicine, Biology and Health, University of Manchester, UKPreventive Neurology Unit, Wolfson Institute of Population Health, QMUL, UK; Department of Neurology, Royal London Hospital, Barts Health NHS Trust, London, UK; Corresponding author. Preventive Neurology Unit, Wolfson Institute of Population Health, Charterhouse Square, London EC1M 6BQ, UK.Summary: A range of long-term neurological conditions may be diagnosed in young adulthood. These conditions are generally not curable, and most people need to take ongoing treatment for symptom control and/or disease modification. When chronic diseases are diagnosed before people have completed their families, there is a need to balance the potential benefits of treatment for the mother against potential risk(s) to the fetus from exposure to medications during pregnancy. Whilst available data regarding short-term fetal outcomes following treatment exposures during pregnancy is rapidly increasing, information regarding longer-term outcomes is more limited. The association of fetal exposure to valproate with serious long-term neurodevelopmental outcomes has highlighted the importance of capturing and evaluating long-term data.In this review we examine available evidence around the long-term effects of treatments used for the most common long-term neurological conditions diagnosed in early adulthood, namely epilepsy, migraine and neuroinflammatory disorders. We draw from existing literature across a range of diseases and discuss strategies to improve future knowledge.http://www.sciencedirect.com/science/article/pii/S2589537023003346PregnancyEpilepsyNeuroinflammationLong term outcomesNeurodevelopmentImmunity |
| spellingShingle | Chen Liu Samuel Pace Rebecca Bromley Ruth Dobson Exposure to medication for neurological disease in pregnancy – time to consider the long-term implications? EClinicalMedicine Pregnancy Epilepsy Neuroinflammation Long term outcomes Neurodevelopment Immunity |
| title | Exposure to medication for neurological disease in pregnancy – time to consider the long-term implications? |
| title_full | Exposure to medication for neurological disease in pregnancy – time to consider the long-term implications? |
| title_fullStr | Exposure to medication for neurological disease in pregnancy – time to consider the long-term implications? |
| title_full_unstemmed | Exposure to medication for neurological disease in pregnancy – time to consider the long-term implications? |
| title_short | Exposure to medication for neurological disease in pregnancy – time to consider the long-term implications? |
| title_sort | exposure to medication for neurological disease in pregnancy time to consider the long term implications |
| topic | Pregnancy Epilepsy Neuroinflammation Long term outcomes Neurodevelopment Immunity |
| url | http://www.sciencedirect.com/science/article/pii/S2589537023003346 |
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