Blockade of glucagon increases muscle mass and alters fiber type composition in mice deficient in proglucagon‐derived peptides

Blockade of glucagon increases muscle mass and alters fiber type composition in mice deficient in proglucagon‐derived peptides

ABSTRACT Aims/Introduction Glucagon is secreted from pancreatic α‐cells and plays an important role in amino acid metabolism in liver. Various animal models deficient in glucagon action show hyper‐amino acidemia and α‐cell hyperplasia, indicating that glucagon contributes to feedback regulation betw...

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Bibliographic Details
Main Authors: Shinji Ueno, Yusuke Seino, Shihomi Hidaka, Masashi Nakatani, Keisuke Hitachi, Naoya Murao, Yasuhiro Maeda, Haruki Fujisawa, Megumi Shibata, Takeshi Takayanagi, Katsumi Iizuka, Daisuke Yabe, Yoshihisa Sugimura, Kunihiro Tsuchida, Yoshitaka Hayashi, Atsushi Suzuki
Format: Article
Language:English
Published: Wiley 2023-09-01
Series:Journal of Diabetes Investigation
Subjects:
Amino acid
Glucagon
Skeletal muscle
Online Access:https://doi.org/10.1111/jdi.14032

Internet

https://doi.org/10.1111/jdi.14032

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