Squaraine nanoparticles for optoacoustic imaging-guided synergistic cancer phototherapy
The unique optical properties of squaraine dyes make them promising for cancer phototheranostics, but the reported squaraines for in vivo treatments mainly rely on their photothermal effect, where monotherapy cannot achieve the desired therapeutic effect. Here we generated a type of squaraine capabl...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2023-08-01
|
| Series: | Nanophotonics |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/nanoph-2023-0358 |
| _version_ | 1797682367175852032 |
|---|---|
| author | Chen Xiao Ma Xiaopeng Yang Gui Huang Guan Dai Haibing Liu Nian Yu Jianbo |
| author_facet | Chen Xiao Ma Xiaopeng Yang Gui Huang Guan Dai Haibing Liu Nian Yu Jianbo |
| author_sort | Chen Xiao |
| collection | DOAJ |
| description | The unique optical properties of squaraine dyes make them promising for cancer phototheranostics, but the reported squaraines for in vivo treatments mainly rely on their photothermal effect, where monotherapy cannot achieve the desired therapeutic effect. Here we generated a type of squaraine capable of killing tumors through both photothermal and photodynamic effects. We optimized squaraine structure with selenium modulation and formulated it into nanoparticles that showed strong absorption of infrared light, negligible fluorescence, good photothermal conversion (66.6 %), and strong photodynamic effects even after several irradiation cycles. In addition, the nanoparticles could be tracked through their strong optoacoustic signal. In mice, the nanoparticles effectively accumulated in tumors and eliminated them upon irradiation, without causing adverse effects. Our work demonstrates the potential of selenium modulation of squaraine for precise cancer diagnosis and treatment through synergistic photothermal and photodynamic effects. |
| first_indexed | 2024-03-11T23:59:38Z |
| format | Article |
| id | doaj.art-f41863bafd7b494aaf64d91f7d786491 |
| institution | Directory Open Access Journal |
| issn | 2192-8614 |
| language | English |
| last_indexed | 2024-03-11T23:59:38Z |
| publishDate | 2023-08-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Nanophotonics |
| spelling | doaj.art-f41863bafd7b494aaf64d91f7d7864912023-09-18T06:32:06ZengDe GruyterNanophotonics2192-86142023-08-0112183645365210.1515/nanoph-2023-0358Squaraine nanoparticles for optoacoustic imaging-guided synergistic cancer phototherapyChen Xiao0Ma Xiaopeng1Yang Gui2Huang Guan3Dai Haibing4Liu Nian5Yu Jianbo6Longgang Central Hospital of Shenzhen, Shenzhen518116, ChinaSchool of Control Science and Engineering, Shandong University, Jinan250061, ChinaLonggang Central Hospital of Shenzhen, Shenzhen518116, ChinaLonggang Central Hospital of Shenzhen, Shenzhen518116, ChinaLonggang Central Hospital of Shenzhen, Shenzhen518116, ChinaPET Center, Department of Nuclear Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou310003, ChinaLonggang Central Hospital of Shenzhen, Shenzhen518116, ChinaThe unique optical properties of squaraine dyes make them promising for cancer phototheranostics, but the reported squaraines for in vivo treatments mainly rely on their photothermal effect, where monotherapy cannot achieve the desired therapeutic effect. Here we generated a type of squaraine capable of killing tumors through both photothermal and photodynamic effects. We optimized squaraine structure with selenium modulation and formulated it into nanoparticles that showed strong absorption of infrared light, negligible fluorescence, good photothermal conversion (66.6 %), and strong photodynamic effects even after several irradiation cycles. In addition, the nanoparticles could be tracked through their strong optoacoustic signal. In mice, the nanoparticles effectively accumulated in tumors and eliminated them upon irradiation, without causing adverse effects. Our work demonstrates the potential of selenium modulation of squaraine for precise cancer diagnosis and treatment through synergistic photothermal and photodynamic effects.https://doi.org/10.1515/nanoph-2023-0358squaraineselenium modulationnanoparticlesoptoacoustic imagingphototherapy |
| spellingShingle | Chen Xiao Ma Xiaopeng Yang Gui Huang Guan Dai Haibing Liu Nian Yu Jianbo Squaraine nanoparticles for optoacoustic imaging-guided synergistic cancer phototherapy Nanophotonics squaraine selenium modulation nanoparticles optoacoustic imaging phototherapy |
| title | Squaraine nanoparticles for optoacoustic imaging-guided synergistic cancer phototherapy |
| title_full | Squaraine nanoparticles for optoacoustic imaging-guided synergistic cancer phototherapy |
| title_fullStr | Squaraine nanoparticles for optoacoustic imaging-guided synergistic cancer phototherapy |
| title_full_unstemmed | Squaraine nanoparticles for optoacoustic imaging-guided synergistic cancer phototherapy |
| title_short | Squaraine nanoparticles for optoacoustic imaging-guided synergistic cancer phototherapy |
| title_sort | squaraine nanoparticles for optoacoustic imaging guided synergistic cancer phototherapy |
| topic | squaraine selenium modulation nanoparticles optoacoustic imaging phototherapy |
| url | https://doi.org/10.1515/nanoph-2023-0358 |
| work_keys_str_mv | AT chenxiao squarainenanoparticlesforoptoacousticimagingguidedsynergisticcancerphototherapy AT maxiaopeng squarainenanoparticlesforoptoacousticimagingguidedsynergisticcancerphototherapy AT yanggui squarainenanoparticlesforoptoacousticimagingguidedsynergisticcancerphototherapy AT huangguan squarainenanoparticlesforoptoacousticimagingguidedsynergisticcancerphototherapy AT daihaibing squarainenanoparticlesforoptoacousticimagingguidedsynergisticcancerphototherapy AT liunian squarainenanoparticlesforoptoacousticimagingguidedsynergisticcancerphototherapy AT yujianbo squarainenanoparticlesforoptoacousticimagingguidedsynergisticcancerphototherapy |