A National Survey of Attitudes and Practices of Physicians Relating to Therapeutic Drug Monitoring and Clinical Pharmacokinetic Service: Strategies for Enhancing Patient’s Care in Saudi Arabia
Ziyad Alrabiah,1,* Abdulrahman Alwhaibi,1,* Sary Alsanea,2 Fars K Alanazi,3 Hisham S Abou-Auda1 1Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh, 11451, Saudi Arabia; 2Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh, Sau...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2021-04-01
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| Series: | International Journal of General Medicine |
| Subjects: | |
| Online Access: | https://www.dovepress.com/a-national-survey-of-attitudes-and-practices-of-physicians-relating-to-peer-reviewed-fulltext-article-IJGM |
| _version_ | 1818657188000825344 |
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| author | Alrabiah Z Alwhaibi A Alsanea S Alanazi FK Abou-Auda HS |
| author_facet | Alrabiah Z Alwhaibi A Alsanea S Alanazi FK Abou-Auda HS |
| author_sort | Alrabiah Z |
| collection | DOAJ |
| description | Ziyad Alrabiah,1,* Abdulrahman Alwhaibi,1,* Sary Alsanea,2 Fars K Alanazi,3 Hisham S Abou-Auda1 1Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh, 11451, Saudi Arabia; 2Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia; 3Kayyali Chair for Pharmaceutical Industries, Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia*These authors contributed equally to this workCorrespondence: Hisham S Abou-Auda Email hishamksu@yahoo.comPurpose: The aim of the study was to evaluate physicians’ perception of the concept of pharmacokinetics and therapeutic drug monitoring (PK/TDM) and their use in clinical practice.Methods: A novel, structured, self-administered questionnaire was designed, validated and distributed to physicians in 3 major cities in Saudi Arabia (Riyadh, Jeddah, Dammam) during a 4-month period. Data were collected on demographics, knowledge and practice of PK/TDM. Attitudes toward integrating these skills into daily clinical practice were also investigated.Results: A total of 724 physicians completed the survey and included in the study. European and North American physicians were found to be more exposed to PK/TDM than other physicians. About 70% of the participants stated that they have applied PK/TDM in their practice, at least, once and most of these were consultants. Only 4.3% of respondents had never checked organ function prior to prescribing narrow therapeutic index drugs. Although the majority (78.4%) perceived PK/TDM as very important to their practice, only 35.3% have tried to calculate drug PK parameters for their patients when necessary.Conclusion: The result of this study showed that the knowledge of physicians about PK/TDM was inadequate. Moreover, the utilization of competent clinical pharmacists trained in PK/TDM was low. An interdisciplinary educational program between the physicians and pharmacist in PK/TDM will lead to a better health care outcome.Keywords: physicians, knowledge, therapeutic drug monitoring, pharmacokinetic parameters |
| first_indexed | 2024-12-17T03:37:30Z |
| format | Article |
| id | doaj.art-f418cbe5bcb545dc8a3e654d20ddf6cd |
| institution | Directory Open Access Journal |
| issn | 1178-7074 |
| language | English |
| last_indexed | 2024-12-17T03:37:30Z |
| publishDate | 2021-04-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of General Medicine |
| spelling | doaj.art-f418cbe5bcb545dc8a3e654d20ddf6cd2022-12-21T22:05:06ZengDove Medical PressInternational Journal of General Medicine1178-70742021-04-01Volume 141513152464229A National Survey of Attitudes and Practices of Physicians Relating to Therapeutic Drug Monitoring and Clinical Pharmacokinetic Service: Strategies for Enhancing Patient’s Care in Saudi ArabiaAlrabiah ZAlwhaibi AAlsanea SAlanazi FKAbou-Auda HSZiyad Alrabiah,1,* Abdulrahman Alwhaibi,1,* Sary Alsanea,2 Fars K Alanazi,3 Hisham S Abou-Auda1 1Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh, 11451, Saudi Arabia; 2Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia; 3Kayyali Chair for Pharmaceutical Industries, Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia*These authors contributed equally to this workCorrespondence: Hisham S Abou-Auda Email hishamksu@yahoo.comPurpose: The aim of the study was to evaluate physicians’ perception of the concept of pharmacokinetics and therapeutic drug monitoring (PK/TDM) and their use in clinical practice.Methods: A novel, structured, self-administered questionnaire was designed, validated and distributed to physicians in 3 major cities in Saudi Arabia (Riyadh, Jeddah, Dammam) during a 4-month period. Data were collected on demographics, knowledge and practice of PK/TDM. Attitudes toward integrating these skills into daily clinical practice were also investigated.Results: A total of 724 physicians completed the survey and included in the study. European and North American physicians were found to be more exposed to PK/TDM than other physicians. About 70% of the participants stated that they have applied PK/TDM in their practice, at least, once and most of these were consultants. Only 4.3% of respondents had never checked organ function prior to prescribing narrow therapeutic index drugs. Although the majority (78.4%) perceived PK/TDM as very important to their practice, only 35.3% have tried to calculate drug PK parameters for their patients when necessary.Conclusion: The result of this study showed that the knowledge of physicians about PK/TDM was inadequate. Moreover, the utilization of competent clinical pharmacists trained in PK/TDM was low. An interdisciplinary educational program between the physicians and pharmacist in PK/TDM will lead to a better health care outcome.Keywords: physicians, knowledge, therapeutic drug monitoring, pharmacokinetic parametershttps://www.dovepress.com/a-national-survey-of-attitudes-and-practices-of-physicians-relating-to-peer-reviewed-fulltext-article-IJGMphysiciansknowledgetherapeutic drug monitoringpharmacokinetic parameters. |
| spellingShingle | Alrabiah Z Alwhaibi A Alsanea S Alanazi FK Abou-Auda HS A National Survey of Attitudes and Practices of Physicians Relating to Therapeutic Drug Monitoring and Clinical Pharmacokinetic Service: Strategies for Enhancing Patient’s Care in Saudi Arabia International Journal of General Medicine physicians knowledge therapeutic drug monitoring pharmacokinetic parameters. |
| title | A National Survey of Attitudes and Practices of Physicians Relating to Therapeutic Drug Monitoring and Clinical Pharmacokinetic Service: Strategies for Enhancing Patient’s Care in Saudi Arabia |
| title_full | A National Survey of Attitudes and Practices of Physicians Relating to Therapeutic Drug Monitoring and Clinical Pharmacokinetic Service: Strategies for Enhancing Patient’s Care in Saudi Arabia |
| title_fullStr | A National Survey of Attitudes and Practices of Physicians Relating to Therapeutic Drug Monitoring and Clinical Pharmacokinetic Service: Strategies for Enhancing Patient’s Care in Saudi Arabia |
| title_full_unstemmed | A National Survey of Attitudes and Practices of Physicians Relating to Therapeutic Drug Monitoring and Clinical Pharmacokinetic Service: Strategies for Enhancing Patient’s Care in Saudi Arabia |
| title_short | A National Survey of Attitudes and Practices of Physicians Relating to Therapeutic Drug Monitoring and Clinical Pharmacokinetic Service: Strategies for Enhancing Patient’s Care in Saudi Arabia |
| title_sort | national survey of attitudes and practices of physicians relating to therapeutic drug monitoring and clinical pharmacokinetic service strategies for enhancing patient rsquo s care in saudi arabia |
| topic | physicians knowledge therapeutic drug monitoring pharmacokinetic parameters. |
| url | https://www.dovepress.com/a-national-survey-of-attitudes-and-practices-of-physicians-relating-to-peer-reviewed-fulltext-article-IJGM |
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