Idiopathic Angioedema: Current Challenges
Aude Belbézier,* Alexis Bocquet,* Laurence Bouillet National Reference Center for Angioedema (CREAK), Department of Internal Medicine/Clinical Immunology, Grenoble Alpes University Hospital, Grenoble, France*These authors contributed equally to this workCorrespondence: Laurence BouilletCe...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2020-04-01
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| Series: | Journal of Asthma and Allergy |
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| Online Access: | https://www.dovepress.com/idiopathic-angioedema-current-challenges-peer-reviewed-article-JAA |
| _version_ | 1818557770534748160 |
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| author | Belbézier A Bocquet A Bouillet L |
| author_facet | Belbézier A Bocquet A Bouillet L |
| author_sort | Belbézier A |
| collection | DOAJ |
| description | Aude Belbézier,* Alexis Bocquet,* Laurence Bouillet National Reference Center for Angioedema (CREAK), Department of Internal Medicine/Clinical Immunology, Grenoble Alpes University Hospital, Grenoble, France*These authors contributed equally to this workCorrespondence: Laurence BouilletCentre de référence des angioedèmes (CREAK), Servicede médecine interne/immunologie clinique, Centre Hospitalier Universitaire de Grenoble Alpes, CS10217, Grenoble cedex 09 38043, FranceTel +33 476765513Fax +33 76765816Email lbouillet@chu-grenoble.frAbstract: The etiological diagnosis of isolated recurrent angioedema poses problems because it must often be done urgently. Angioedema secondary to nonspecific mast cell activation (MC-AE) is the most frequent form and is usually mild. Bradykinin mediated angioedema (BK-AE) is rarer but potentially fatal in the absence of the correct treatment. Few biological markers exist. The C1-inhibitor (C1-inh) functional assay can exclude AE due to C1-inh deficiency. Genetic diagnoses of hereditary AE due to abnormal C1-inh AE have progressed with four currently known mutations. However, determining the physiopathological mechanism leading to some isolated AE cases is sometimes very difficult. In such cases, therapeutic tests are then the only solution: antihistamines at high doses and omalizumab for suspected MC-AE, icatibant for suspected AE-BK. Identifying new markers would be a great help.Keywords: angioedema, mast cell, bradykinin, C1 inhibitor, histamine |
| first_indexed | 2024-12-14T00:03:56Z |
| format | Article |
| id | doaj.art-f41d06dcacb24da4a453a400d37b6830 |
| institution | Directory Open Access Journal |
| issn | 1178-6965 |
| language | English |
| last_indexed | 2024-12-14T00:03:56Z |
| publishDate | 2020-04-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Journal of Asthma and Allergy |
| spelling | doaj.art-f41d06dcacb24da4a453a400d37b68302022-12-21T23:26:10ZengDove Medical PressJournal of Asthma and Allergy1178-69652020-04-01Volume 1313714453136Idiopathic Angioedema: Current ChallengesBelbézier ABocquet ABouillet LAude Belbézier,* Alexis Bocquet,* Laurence Bouillet National Reference Center for Angioedema (CREAK), Department of Internal Medicine/Clinical Immunology, Grenoble Alpes University Hospital, Grenoble, France*These authors contributed equally to this workCorrespondence: Laurence BouilletCentre de référence des angioedèmes (CREAK), Servicede médecine interne/immunologie clinique, Centre Hospitalier Universitaire de Grenoble Alpes, CS10217, Grenoble cedex 09 38043, FranceTel +33 476765513Fax +33 76765816Email lbouillet@chu-grenoble.frAbstract: The etiological diagnosis of isolated recurrent angioedema poses problems because it must often be done urgently. Angioedema secondary to nonspecific mast cell activation (MC-AE) is the most frequent form and is usually mild. Bradykinin mediated angioedema (BK-AE) is rarer but potentially fatal in the absence of the correct treatment. Few biological markers exist. The C1-inhibitor (C1-inh) functional assay can exclude AE due to C1-inh deficiency. Genetic diagnoses of hereditary AE due to abnormal C1-inh AE have progressed with four currently known mutations. However, determining the physiopathological mechanism leading to some isolated AE cases is sometimes very difficult. In such cases, therapeutic tests are then the only solution: antihistamines at high doses and omalizumab for suspected MC-AE, icatibant for suspected AE-BK. Identifying new markers would be a great help.Keywords: angioedema, mast cell, bradykinin, C1 inhibitor, histaminehttps://www.dovepress.com/idiopathic-angioedema-current-challenges-peer-reviewed-article-JAAangioedemamast cellbradykininc1inhibitorhistamine |
| spellingShingle | Belbézier A Bocquet A Bouillet L Idiopathic Angioedema: Current Challenges Journal of Asthma and Allergy angioedema mast cell bradykinin c1inhibitor histamine |
| title | Idiopathic Angioedema: Current Challenges |
| title_full | Idiopathic Angioedema: Current Challenges |
| title_fullStr | Idiopathic Angioedema: Current Challenges |
| title_full_unstemmed | Idiopathic Angioedema: Current Challenges |
| title_short | Idiopathic Angioedema: Current Challenges |
| title_sort | idiopathic angioedema current challenges |
| topic | angioedema mast cell bradykinin c1inhibitor histamine |
| url | https://www.dovepress.com/idiopathic-angioedema-current-challenges-peer-reviewed-article-JAA |
| work_keys_str_mv | AT belbeziera idiopathicangioedemacurrentchallenges AT bocqueta idiopathicangioedemacurrentchallenges AT bouilletl idiopathicangioedemacurrentchallenges |