Penicillin Resistance in Streptococcus pneumoniae Strains
Penicillin has been used for the treatment of pneumococcal infections with success for many years, but recently penicillin resistant Streptococcus pneumoniae strains has been reported worldwide. The aim of this study was to investigate the rate of resistance of S. pneumoniae strains to penicillin. T...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Bilimsel Tip Yayinevi
1999-12-01
|
| Series: | Flora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi |
| Subjects: | |
| Online Access: | http://www.floradergisi.org/getFileContent.aspx?op=REDPDF&file_name=1999-4-4-287-292.pdf |
| Summary: | Penicillin has been used for the treatment of pneumococcal infections with success for many years, but recently penicillin resistant Streptococcus pneumoniae strains has been reported worldwide. The aim of this study was to investigate the rate of resistance of S. pneumoniae strains to penicillin. The penicillin resistance was investigated in 101 S. pneumoniae strains by using oxacillin disk diffusion screening test. The minimum inhibitory concentration (MIC) values of penicillin, cefotaxime and ceftriaxone of oxacillin resistant strains were detected by using E test. The resistance of all isolates to erythromycin, chloramphenicol, tetracycline and trimethoprim/sulfamethoxazole (TMP/SMX) were investigated by disk diffusion method. In the oxacillin screening test it was found that 28 of 101 S. pneumoniae strains were penicillin resistant. By determining the MIC values of this penicillin resistant strains, it was detected that 6 (21.4%) of this strains were penicillin susceptible. Twenty-two oxacillin (1µg) resistant strains were found to have MIC values of penicillin within 0.1-1 µg/mL namely “intermediate” category. Penicillin resistance was found to be 21.8%. Among the penicillin resistant isolates, neither high level penicillin resistance, nor resistance to cefotaxime and ceftriaxone was detected. The susceptibility of 101 S. pneumoniae strains to erythromycin, chloramphenicol, tetracycline, TMP/SMX were found to be as 96.0%, 98.0%, 77.2% and 64.4%, respectively. |
|---|---|
| ISSN: | 1300-932X 1300-932X |