Prophylactic administration of oral calcium carbonate during plateletpheresis: A bicentric prospective study
Background: Administration of anticoagulant citrate and dextrose (ACD-A) chelates ionized calcium in blood and causes hypocalcemia in plateletpheresis donors. The aim of the study was to observe the effects of oral calcium (Ca) supplementation during plateletpheresis on various parameters related to...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2020-01-01
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| Series: | Asian Journal of Transfusion Science |
| Subjects: | |
| Online Access: | http://www.ajts.org/article.asp?issn=0973-6247;year=2020;volume=14;issue=1;spage=19;epage=22;aulast=Pandey |
| _version_ | 1818161280796590080 |
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| author | Prashant Kumar Pandey Aseem Tiwari Nitin Agarwal Ravi C Dara |
| author_facet | Prashant Kumar Pandey Aseem Tiwari Nitin Agarwal Ravi C Dara |
| author_sort | Prashant Kumar Pandey |
| collection | DOAJ |
| description | Background: Administration of anticoagulant citrate and dextrose (ACD-A) chelates ionized calcium in blood and causes hypocalcemia in plateletpheresis donors. The aim of the study was to observe the effects of oral calcium (Ca) supplementation during plateletpheresis on various parameters related to calcium metabolism.
Materials and Methods: This study was performed between January 2014 and December 2014 on 200 plateletpheresis donors.They were divided into two groups. In group A donors (n=100), no prophylactic oral calcium supplementation was given. In group B (n=100) donors, 2000 mg of calcium was given one hour before the start of the procedure, 500 mg was given at the start of the procedure and 500 mg calcium was given just before the end of procedure. Biochemical parameters like serum total calcium (T Ca), serum total magnesium (T Mg) and ionized calcium level (iCa) were measured before and after the procedure. Relative risk of citrate toxicity was measured between the two groups.
Results: There was a significant fall in total calcium (pre 9.02 mg/dl, post 8.23 mg/dl,), ionized calcium level (pre 1.14 mmol/L, post 0.91 mmol/L) and total magnesium (pre 1.92 mg/dl, post 1.79 mg/dl) amongst the donors who did not receive prophylactic calcium supplementation. Despite calcium intake, in prophylactic calcium intake group, we did observe a significant drop in total magnesium (pre 2.04 mg/dl, post 1.94 mg/dl) and ionized calcium level (pre 1.25 mmol/L, post 1.12 mmol/L, p<0.01). We did observe a drop in total calcium level, however, this observation was not statistically significant. The risk (RR=5.44) of citrate toxicity was higher among group A donors.
Conclusion: Prophylactic oral calcium carbonate supplementation would help in to reduce the risk of citrate toxicity. Therefore, we suggest for prophylactic oral administration of 3000 mg elemental calcium carbonate in three divided doses to make PP procedures uneventful. |
| first_indexed | 2024-12-11T16:15:16Z |
| format | Article |
| id | doaj.art-f42006628d40406b94ccb30998ca9bcc |
| institution | Directory Open Access Journal |
| issn | 0973-6247 1998-3565 |
| language | English |
| last_indexed | 2024-12-11T16:15:16Z |
| publishDate | 2020-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Asian Journal of Transfusion Science |
| spelling | doaj.art-f42006628d40406b94ccb30998ca9bcc2022-12-22T00:58:58ZengWolters Kluwer Medknow PublicationsAsian Journal of Transfusion Science0973-62471998-35652020-01-01141192210.4103/ajts.AJTS_114_17Prophylactic administration of oral calcium carbonate during plateletpheresis: A bicentric prospective studyPrashant Kumar PandeyAseem TiwariNitin AgarwalRavi C DaraBackground: Administration of anticoagulant citrate and dextrose (ACD-A) chelates ionized calcium in blood and causes hypocalcemia in plateletpheresis donors. The aim of the study was to observe the effects of oral calcium (Ca) supplementation during plateletpheresis on various parameters related to calcium metabolism. Materials and Methods: This study was performed between January 2014 and December 2014 on 200 plateletpheresis donors.They were divided into two groups. In group A donors (n=100), no prophylactic oral calcium supplementation was given. In group B (n=100) donors, 2000 mg of calcium was given one hour before the start of the procedure, 500 mg was given at the start of the procedure and 500 mg calcium was given just before the end of procedure. Biochemical parameters like serum total calcium (T Ca), serum total magnesium (T Mg) and ionized calcium level (iCa) were measured before and after the procedure. Relative risk of citrate toxicity was measured between the two groups. Results: There was a significant fall in total calcium (pre 9.02 mg/dl, post 8.23 mg/dl,), ionized calcium level (pre 1.14 mmol/L, post 0.91 mmol/L) and total magnesium (pre 1.92 mg/dl, post 1.79 mg/dl) amongst the donors who did not receive prophylactic calcium supplementation. Despite calcium intake, in prophylactic calcium intake group, we did observe a significant drop in total magnesium (pre 2.04 mg/dl, post 1.94 mg/dl) and ionized calcium level (pre 1.25 mmol/L, post 1.12 mmol/L, p<0.01). We did observe a drop in total calcium level, however, this observation was not statistically significant. The risk (RR=5.44) of citrate toxicity was higher among group A donors. Conclusion: Prophylactic oral calcium carbonate supplementation would help in to reduce the risk of citrate toxicity. Therefore, we suggest for prophylactic oral administration of 3000 mg elemental calcium carbonate in three divided doses to make PP procedures uneventful.http://www.ajts.org/article.asp?issn=0973-6247;year=2020;volume=14;issue=1;spage=19;epage=22;aulast=Pandeycitrate toxicityhypocalcemiaoral calcium carbonateplateletpheresis |
| spellingShingle | Prashant Kumar Pandey Aseem Tiwari Nitin Agarwal Ravi C Dara Prophylactic administration of oral calcium carbonate during plateletpheresis: A bicentric prospective study Asian Journal of Transfusion Science citrate toxicity hypocalcemia oral calcium carbonate plateletpheresis |
| title | Prophylactic administration of oral calcium carbonate during plateletpheresis: A bicentric prospective study |
| title_full | Prophylactic administration of oral calcium carbonate during plateletpheresis: A bicentric prospective study |
| title_fullStr | Prophylactic administration of oral calcium carbonate during plateletpheresis: A bicentric prospective study |
| title_full_unstemmed | Prophylactic administration of oral calcium carbonate during plateletpheresis: A bicentric prospective study |
| title_short | Prophylactic administration of oral calcium carbonate during plateletpheresis: A bicentric prospective study |
| title_sort | prophylactic administration of oral calcium carbonate during plateletpheresis a bicentric prospective study |
| topic | citrate toxicity hypocalcemia oral calcium carbonate plateletpheresis |
| url | http://www.ajts.org/article.asp?issn=0973-6247;year=2020;volume=14;issue=1;spage=19;epage=22;aulast=Pandey |
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