Ventricular apparent diffusion coefficient measurements in patients with neoplastic leptomeningeal disease
Abstract Background To test the hypothesis that intraventricular ADC values can be used to determine the presence of neoplastic leptomeningeal disease (LMD). Materials and methods ADC values were measured at multiple sites in the ventricular system in 32 patients with cytologically-proven LMD and 40...
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| Format: | Article |
| Language: | English |
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BMC
2020-06-01
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| Series: | Cancer Imaging |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s40644-020-00305-2 |
| _version_ | 1819298280453963776 |
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| author | James M. Debnam Ryan B. Said Heng-Hsiao Liu Jia Sun Jihong Wang Wei Wei Dima Suki Rory R. Mayer T. Linda Chi Leena Ketonen Nandita Guha-Thakurta Jeffrey S. Weinberg |
| author_facet | James M. Debnam Ryan B. Said Heng-Hsiao Liu Jia Sun Jihong Wang Wei Wei Dima Suki Rory R. Mayer T. Linda Chi Leena Ketonen Nandita Guha-Thakurta Jeffrey S. Weinberg |
| author_sort | James M. Debnam |
| collection | DOAJ |
| description | Abstract Background To test the hypothesis that intraventricular ADC values can be used to determine the presence of neoplastic leptomeningeal disease (LMD). Materials and methods ADC values were measured at multiple sites in the ventricular system in 32 patients with cytologically-proven LMD and 40 control subjects. Multiple linear regression analysis was used to determine the mean difference of ADCs between the LMD and control groups after adjusting for ventricle size and tumor type. Receiver operating characteristics (ROC) analysis was performed and optimal ADC value cut-off point for predicting the presence of LMD. ADC was compared to T1 enhancement and FLAIR signal hyperintensity for determining the presence of LMD. Results After adjusting for ventricular volume and tumor type, the mid body of lateral ventricles showed no significant difference in ventricular volume and a significant difference in ADC values between the control and LMD groups (p > 0.05). In the mid-body of the right lateral ventricle the AUC was 0.69 (95% CI 0.57–0.81) with an optimal ADC cut off point of 3.22 × 10− 9 m2/s (sensitivity, specificity; 0.72, 0.68). In the mid-body of left lateral ventricle the AUC was 0.7 (95% CI 0.58–0.82) with an optimal cut-off point of 3.23 × 10− 9 m2/s (0.81, 0.62). Using an average value of HU measurements in the lateral ventricles the AUC was 0.73 (95% CI 0.61–0.84) with an optimal cut off point was 3.11 × 10− 9 m2/s (0.78, 0.65). Compared to the T1 post-contrast series, ADC was predictive of the presence of LMD in the mid-body of the left lateral ventricle (p = 0.036). Conclusion Complex interactions affect ADC measurements in patients with LMD. ADC values in the lateral ventricles may provide non-invasive clues to the presence of LMD. |
| first_indexed | 2024-12-24T05:27:23Z |
| format | Article |
| id | doaj.art-f42071d60606493eab3b102e290c65ce |
| institution | Directory Open Access Journal |
| issn | 1470-7330 |
| language | English |
| last_indexed | 2024-12-24T05:27:23Z |
| publishDate | 2020-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Cancer Imaging |
| spelling | doaj.art-f42071d60606493eab3b102e290c65ce2022-12-21T17:13:17ZengBMCCancer Imaging1470-73302020-06-0120111110.1186/s40644-020-00305-2Ventricular apparent diffusion coefficient measurements in patients with neoplastic leptomeningeal diseaseJames M. Debnam0Ryan B. Said1Heng-Hsiao Liu2Jia Sun3Jihong Wang4Wei Wei5Dima Suki6Rory R. Mayer7T. Linda Chi8Leena Ketonen9Nandita Guha-Thakurta10Jeffrey S. Weinberg11Department of Neuroradiology, The University of Texas MD Anderson Cancer CenterDepartment of Neuroradiology, The University of Texas MD Anderson Cancer CenterDepartment of Neuroradiology, The University of Texas MD Anderson Cancer CenterDepartment of Biostatistics, The University of Texas MD Anderson Cancer CenterDepartment of Radiation Physics, The University of Texas MD Anderson Cancer CenterDepartment of Biostatistics, The University of Texas MD Anderson Cancer CenterDepartment of Neurosurgery, The University of Texas MD Anderson Cancer CenterDepartment of Neurosurgery, University of California San FranciscoDepartment of Neuroradiology, The University of Texas MD Anderson Cancer CenterDepartment of Neuroradiology, The University of Texas MD Anderson Cancer CenterDepartment of Neuroradiology, The University of Texas MD Anderson Cancer CenterDepartment of Neurosurgery, The University of Texas MD Anderson Cancer CenterAbstract Background To test the hypothesis that intraventricular ADC values can be used to determine the presence of neoplastic leptomeningeal disease (LMD). Materials and methods ADC values were measured at multiple sites in the ventricular system in 32 patients with cytologically-proven LMD and 40 control subjects. Multiple linear regression analysis was used to determine the mean difference of ADCs between the LMD and control groups after adjusting for ventricle size and tumor type. Receiver operating characteristics (ROC) analysis was performed and optimal ADC value cut-off point for predicting the presence of LMD. ADC was compared to T1 enhancement and FLAIR signal hyperintensity for determining the presence of LMD. Results After adjusting for ventricular volume and tumor type, the mid body of lateral ventricles showed no significant difference in ventricular volume and a significant difference in ADC values between the control and LMD groups (p > 0.05). In the mid-body of the right lateral ventricle the AUC was 0.69 (95% CI 0.57–0.81) with an optimal ADC cut off point of 3.22 × 10− 9 m2/s (sensitivity, specificity; 0.72, 0.68). In the mid-body of left lateral ventricle the AUC was 0.7 (95% CI 0.58–0.82) with an optimal cut-off point of 3.23 × 10− 9 m2/s (0.81, 0.62). Using an average value of HU measurements in the lateral ventricles the AUC was 0.73 (95% CI 0.61–0.84) with an optimal cut off point was 3.11 × 10− 9 m2/s (0.78, 0.65). Compared to the T1 post-contrast series, ADC was predictive of the presence of LMD in the mid-body of the left lateral ventricle (p = 0.036). Conclusion Complex interactions affect ADC measurements in patients with LMD. ADC values in the lateral ventricles may provide non-invasive clues to the presence of LMD.http://link.springer.com/article/10.1186/s40644-020-00305-2Apparent diffusion coefficientVentriclesCerebrospinal fluidMagnetic resonance imaging |
| spellingShingle | James M. Debnam Ryan B. Said Heng-Hsiao Liu Jia Sun Jihong Wang Wei Wei Dima Suki Rory R. Mayer T. Linda Chi Leena Ketonen Nandita Guha-Thakurta Jeffrey S. Weinberg Ventricular apparent diffusion coefficient measurements in patients with neoplastic leptomeningeal disease Cancer Imaging Apparent diffusion coefficient Ventricles Cerebrospinal fluid Magnetic resonance imaging |
| title | Ventricular apparent diffusion coefficient measurements in patients with neoplastic leptomeningeal disease |
| title_full | Ventricular apparent diffusion coefficient measurements in patients with neoplastic leptomeningeal disease |
| title_fullStr | Ventricular apparent diffusion coefficient measurements in patients with neoplastic leptomeningeal disease |
| title_full_unstemmed | Ventricular apparent diffusion coefficient measurements in patients with neoplastic leptomeningeal disease |
| title_short | Ventricular apparent diffusion coefficient measurements in patients with neoplastic leptomeningeal disease |
| title_sort | ventricular apparent diffusion coefficient measurements in patients with neoplastic leptomeningeal disease |
| topic | Apparent diffusion coefficient Ventricles Cerebrospinal fluid Magnetic resonance imaging |
| url | http://link.springer.com/article/10.1186/s40644-020-00305-2 |
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