Mast cells as important regulators in the development of psoriasis
Psoriasis is a chronic inflammatory immune skin disease mediated by genetic and environmental factors. As a bridge between innate and adaptive immunity, mast cells are involved in the initiation, development, and maintenance of psoriasis by interactions and communication with a variety of cells. The...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1022986/full |
| _version_ | 1811331310707277824 |
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| author | Xu-Yue Zhou Kun Chen Jia-An Zhang |
| author_facet | Xu-Yue Zhou Kun Chen Jia-An Zhang |
| author_sort | Xu-Yue Zhou |
| collection | DOAJ |
| description | Psoriasis is a chronic inflammatory immune skin disease mediated by genetic and environmental factors. As a bridge between innate and adaptive immunity, mast cells are involved in the initiation, development, and maintenance of psoriasis by interactions and communication with a variety of cells. The current review describes interactions of mast cells with T cells, Tregs, keratinocytes, adipocytes, and sensory neurons in psoriasis to emphasize the important role of mast cell-centered cell networks in psoriasis. |
| first_indexed | 2024-04-13T16:17:40Z |
| format | Article |
| id | doaj.art-f422dd07c8f348c9844c4ade9c80215e |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-13T16:17:40Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-f422dd07c8f348c9844c4ade9c80215e2022-12-22T02:40:01ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-11-011310.3389/fimmu.2022.10229861022986Mast cells as important regulators in the development of psoriasisXu-Yue ZhouKun ChenJia-An ZhangPsoriasis is a chronic inflammatory immune skin disease mediated by genetic and environmental factors. As a bridge between innate and adaptive immunity, mast cells are involved in the initiation, development, and maintenance of psoriasis by interactions and communication with a variety of cells. The current review describes interactions of mast cells with T cells, Tregs, keratinocytes, adipocytes, and sensory neurons in psoriasis to emphasize the important role of mast cell-centered cell networks in psoriasis.https://www.frontiersin.org/articles/10.3389/fimmu.2022.1022986/fullmast cellpsoriasisT cellcell networkinflammation |
| spellingShingle | Xu-Yue Zhou Kun Chen Jia-An Zhang Mast cells as important regulators in the development of psoriasis Frontiers in Immunology mast cell psoriasis T cell cell network inflammation |
| title | Mast cells as important regulators in the development of psoriasis |
| title_full | Mast cells as important regulators in the development of psoriasis |
| title_fullStr | Mast cells as important regulators in the development of psoriasis |
| title_full_unstemmed | Mast cells as important regulators in the development of psoriasis |
| title_short | Mast cells as important regulators in the development of psoriasis |
| title_sort | mast cells as important regulators in the development of psoriasis |
| topic | mast cell psoriasis T cell cell network inflammation |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1022986/full |
| work_keys_str_mv | AT xuyuezhou mastcellsasimportantregulatorsinthedevelopmentofpsoriasis AT kunchen mastcellsasimportantregulatorsinthedevelopmentofpsoriasis AT jiaanzhang mastcellsasimportantregulatorsinthedevelopmentofpsoriasis |