Curdione ameliorates bleomycin-induced pulmonary fibrosis by repressing TGF-β-induced fibroblast to myofibroblast differentiation

Curdione ameliorates bleomycin-induced pulmonary fibrosis by repressing TGF-β-induced fibroblast to myofibroblast differentiation

Abstract Background Idiopathic pulmonary fibrosis (IPF) is a progressive and irreversible disease characterized by excessive fibroblast to myofibroblast differentiation with limited therapeutic options. Curdione, a sesquiterpene compound extracted from the essential oil of Curcuma aromatica Salisb,...

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Bibliographic Details
Main Authors: Peng Liu, Kang Miao, Lei Zhang, Yong Mou, Yongjian Xu, Weining Xiong, Jun Yu, Yi Wang
Format: Article
Language:English
Published: BMC 2020-02-01
Series:Respiratory Research
Subjects:
IPF
Fibroblast
Myofibroblast
Curdione
TGF-β1
Online Access:http://link.springer.com/article/10.1186/s12931-020-1300-y

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