Subset-based method for cross-tissue transcriptome-wide association studies improves power and interpretability

Subset-based method for cross-tissue transcriptome-wide association studies improves power and interpretability

Summary: Integrating results from genome-wide association studies (GWASs) and studies of molecular phenotypes such as gene expressions can improve our understanding of the biological functions of trait-associated variants and can help prioritize candidate genes for downstream analysis. Using referen...

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Bibliographic Details
Main Authors: Xinyu Guo, Nilanjan Chatterjee, Diptavo Dutta
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:HGG Advances
Subjects:
cross-tissue
TWAS
meta analysis
associated-tissue
GWAS summary statistics
gene-based test
Online Access:http://www.sciencedirect.com/science/article/pii/S2666247724000228

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